Who's your neighbor? New computational approaches for functional genomics

The COG database: a tool for genome-scale analysis of protein functions and evolution

2000 • 4,098 citations

A Genomic Perspective on Protein Families

1997 • 3,531 citations

Phylogenetic Classification and the Universal Tree

1999 • 1,872 citations

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

1999 • 1,661 citations

Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

1999 • 1,556 citations

Distinguishing Homologous from Analogous Proteins

1970 • 1,512 citations

The use of gene clusters to infer functional coupling

1999 • 1,251 citations

Protein interaction maps for complete genomes based on gene fusion events

1999 • 1,090 citations

Conservation of gene order: a fingerprint of proteins that physically interact

1998 • 1,054 citations

A combined algorithm for genome-wide prediction of protein function

1999 • 921 citations

A minimal gene set for cellular life derived by comparison of complete bacterial genomes.

1996 • 911 citations

Protein Interaction Mapping in C. elegans Using Proteins Involved in Vulval Development

2000 • 769 citations

You are what you eat: a gene transfer ratchet could account for bacterial genes in eukaryotic nuclear genomes

1998 • 607 citations

The GAF domain: an evolutionary link between diverse phototransducing proteins

1997 • 572 citations

Archaea and the prokaryote-to-eukaryote transition

1997 • 440 citations

Predicting function: from genes to genomes and back 1 1Edited by P. E. Wright

1998 • 422 citations

Evolution of Aminoacyl-tRNA Synthetases—Analysis of Unique Domain Architectures and Phylogenetic Trees Reveals a Complex History of Horizontal Gene Transfer Events

1999 • 411 citations

Gene Families: The Taxonomy of Protein Paralogs and Chimeras

1997 • 387 citations

Predicting functions from protein sequences—where are the bottlenecks?

1998 • 311 citations

A minimal gene set for cellular life derived by comparison of complete bacterial genomes

1996 • 295 citations

Archaea and the prokaryote-to-eukaryote transition.

1997 • 272 citations

Comparative Genomics of the Archaea (Euryarchaeota): Evolution of Conserved Protein Families, the Stable Core, and the Variable Shell

1999 • 270 citations

Pathway alignment: application to the comparative analysis of glycolytic enzymes

1999 • 240 citations

A Euryarchaeal Lysyl-tRNA Synthetase: Resemblance to Class I Synthetases

1997 • 194 citations

Prediction of transcription regulatory sites in Archaea by a comparative genomic approach

2000 • 194 citations

Variation and evolution of the citric-acid cycle: a genomic perspective

1999 • 190 citations

Genome evolution

2000 • 184 citations

Molecular complementation of a genetic marker in Dictyostelium using a genomic DNA library.

1989 • 171 citations

Beyond complete genomes: from sequence to structure and function

1998 • 162 citations

Computer analysis of transcription regulatory patterns in completely sequenced bacterial genomes

1999 • 138 citations

MIPS: a database for protein sequences and complete genomes

1998 • 135 citations

Use of contiguity on the chromosome to predict functional coupling.

1999 • 134 citations

Microbial Genescapes: Phyletic and Functional Patterns of ORF Distribution among Prokaryotes

1998 • 133 citations

Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi

1997 • 89 citations

Gene and context: Integrative approaches to genome analysis

2000 • 75 citations

The dhnA gene of Escherichia coli encodes a Class I fructose bisphosphate aldolase

1998 • 67 citations

Bacillus subtilis CcdA-defective mutants are blocked in a late step of cytochrome c biogenesis

1997 • 62 citations

Aldolases of the DhnA family: a possible solution to the problem of pentose and hexose biosynthesis in archaea

2000 • 37 citations

Do you dig my groove?

1999 • 15 citations