Furin/PACE/SPC1: A convertase involved in exocytic and endocytic processing of precursor proteins

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

1992 • 688 citations

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60

1992 • 572 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease

1989 • 395 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.

1995 • 247 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

1993 • 211 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

Retrieval of TGN proteins from the cell surface requires endosomal acidification.

1994 • 189 citations

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

1994 • 169 citations

Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.

1992 • 154 citations

Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.

1994 • 151 citations

Proteases and posttranslational processing of prohormones: a review

1983 • 144 citations

A Mutation of Furin Causes the Lack of Precursor-Processing Activity in Human Colon Carcinoma LoVo Cells

1993 • 125 citations

Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus

1995 • 110 citations

Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus

1994 • 107 citations

Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

1995 • 102 citations

Processing of proendothelin‐1 by human furin convertase

1995 • 102 citations

Characterization of a Secreted Form of Human Furin Endoprotease

1993 • 91 citations

Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor

1995 • 86 citations

Arg15-Lys17-Arg18 turkey ovomucoid third domain inhibits human furin

1993 • 80 citations

Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene.

1993 • 62 citations

Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters.

1994 • 59 citations

A unique Kex2-like endoprotease from Drosophila melanogaster is expressed in the central nervous system during early embryogenesis.

1992 • 58 citations

Sequence of the cDNA encoding rat furin, a possible propeptide-processing endoprotease

1990 • 55 citations

PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE

1993 • 55 citations

An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor

1995 • 52 citations

Processing Specificity and Biosynthesis of the Drosophila melanogaster Convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2

1995 • 51 citations

Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin.

1993 • 51 citations

A unique Kex2-like endoprotease from Drosophila melanogaster is expressed in the central nervous system during early embryogenesis

1992 • 46 citations

Sequence Requirements for Endoproteolytic Processing of Precursor Proteins by Fur in: Transfection and In Vitro Experiments1

1994 • 34 citations

Design and synthesis of novel inhibitors of prohormone convertases

1994 • 33 citations

Internally Quenched Fluorogenic Substrate for Furin

1995 • 30 citations

Structural characterization of a Lymnaea putative endoprotease related to human furin

1994 • 19 citations

Molecular Cloning and Cellular Localization of a Furin-Like Prohormone Convertase from the Atrial Gland ofAplysia

1995 • 16 citations

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