Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

IDENTIFYING NONPOLAR TRANSBILAYER HELICES IN AMINO ACID SEQUENCES OF MEMBRANE PROTEINS

1986 • 1,495 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1983 • 1,143 citations

[17] Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis

1983 • 1,115 citations

Purification and Properties of an Endo-β-N-acetylglucosaminidase from Streptomyces griseus

1974 • 870 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Dissecting the catalytic triad of a serine protease

1988 • 621 citations

Progress in Unraveling Pathways of Golgi Traffic

1985 • 615 citations

Demonstration of peptide:N-glycosidase F activity in endo-beta-N-acetylglucosaminidase F preparations.

1984 • 588 citations

Easy identification of cDNA clones.

1983 • 587 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

PROTEIN GLYCOSYLATION IN YEAST

1987 • 437 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

1989 • 386 citations

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.

1983 • 369 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane.

1988 • 356 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

Protein glycosylation in yeast

1987 • 339 citations

Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

1989 • 336 citations

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

1985 • 301 citations

Transformation of yeast spheroplasts without cell fusion

1987 • 266 citations

A single amino acid change in the cytoplasmic domain allows the influenza virus hemagglutinin to be endocytosed through coated pits

1988 • 245 citations

Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases

1988 • 236 citations

Site-directed mutagenesis and the role of the oxyanion hole in subtilisin.

1986 • 236 citations

Secretion and processing of insulin precursors in yeast.

1986 • 227 citations

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.

1986 • 217 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Yeast KEX2 Endopeptidase Correctly Cleaves a Neuroendocrine Prohormone in Mammalian Cells

1988 • 173 citations

Protease B of the lysosomelike vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases.

1987 • 161 citations

Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).

1989 • 157 citations

Clathrin: A Role in the Intracellular Retention of a Golgi Membrane Protein

1989 • 154 citations

Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene.

1986 • 151 citations

[20] Removal of sodium dodecyl sulfate from proteins by ion-pair extraction

1983 • 144 citations

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas.

1987 • 144 citations

Importance of hydrogen-bond formation in stabilizing the transition state of subtilisin

1986 • 136 citations

Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor.

1987 • 132 citations

Primary structural requirements for the enzymatic formation of the N-glycosidic bond in glycoproteins. Studies with alpha-lactalbumin

1978 • 124 citations

Proteases and the processing of precursors to secreted proteins in yeast

1988 • 97 citations

Yeast KEX2 Protease Has the Properties of a Human Proalbumin Converting Enzyme

1987 • 85 citations

Yeast KEX2 protease and mannosyltransferase I are localized to distinct compartments of the secretory pathway

1989 • 81 citations

Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes.

1988 • 80 citations

Purification and characterization of the inducible a agglutinin of Saccharomyces cerevisiae.

1988 • 75 citations

Protein transport and secretion

1983 • 69 citations

Identification of tubulin from the yeast Saccharomyces cerevisiae.

1978 • 63 citations

Processing and metabolism of neuropeptides.

1986 • 57 citations

The separation of d/l amino acid pairs by high-performance liquid chromatography after precolumn derivatization with optically active naphthylethyl isocyanate

1987 • 23 citations