Processing of proendothelin‐1 by human furin convertase

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

1992 • 688 citations

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

1992 • 628 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60

1992 • 572 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

Identification and Functional Expression of a New Member of the Mammalian Kex2-Like Processing Endoprotease Family: Its Striking Structural Similarity to PACE41

1993 • 185 citations

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

1991 • 162 citations

Proteases and posttranslational processing of prohormones: a review

1983 • 144 citations

Evidence for involvement of furin in cleavage and activation of diphtheria toxin.

1993 • 137 citations

Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes

1992 • 130 citations

Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin

1993 • 129 citations

Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3

1992 • 129 citations

PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway.

1993 • 123 citations

Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus

1994 • 107 citations

Characterization of a Secreted Form of Human Furin Endoprotease

1993 • 91 citations

Mammalian Paired Basic Amino Acid Convertases of Prohormones and Proproteins^a

1993 • 76 citations

Evidence for a differential location of vasoconstrictor endothelin receptors in the vasculature

1994 • 62 citations

Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin.

1993 • 51 citations

A sandwich-type enzyme immunoassay to detect immunoreactive big-endothelin-1 in plasma

1990 • 44 citations

Different pharmacological profiles of big‐endothelin‐3 and big‐endothelin‐1 in vivo and in vitro

1991 • 41 citations

Presence of Furin mRNA in Cultured Bovine Endothelial Cells and Possible Involvement of Furin in the Processing of the Endothelin Precursor

1993 • 37 citations

Prohormone convertases revealed at last

1991 • 35 citations

Presence of a phosphoramidon-sensitive endothelin-converting enzyme which converts big-endothelin-1, but not big-endothelin-3, in the rat vas deferens

1991 • 32 citations

Processing of prodynorphin in BRL-3A cells, a rat liver-derived cell line: implications for the specificity of neuropeptide-processing enzymes

1993 • 11 citations

Conversion of proendothelin-1 into endothelin-1 by aspartylproteases

2009 • 4 citations