Hepatitis B virus-related hepatocarcinogenesis: Molecular oncogenic potential of clear or occult infections

Risk of Hepatocellular Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA Level

2006 • 3,012 citations

Viral hepatitis B

2003 • 1,771 citations

The hepatitis B virus

1985 • 1,219 citations

MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1989 • 1,210 citations

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

2006 • 1,129 citations

Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B

2000 • 940 citations

Occult Hepatitis B Virus Infection in Patients with Chronic Hepatitis C Liver Disease

1999 • 666 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma

1980 • 610 citations

Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: Clinically significant or purely “occult”?

2001 • 559 citations

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication

1996 • 474 citations

Natural History and Prognosis of Hepatitis B

2003 • 422 citations

Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients

2002 • 422 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection

2003 • 416 citations

A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.

1990 • 412 citations

Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease

2003 • 410 citations

Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.

1994 • 375 citations

Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen.

1986 • 345 citations

Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells

1993 • 333 citations

Hepatitis B virus X protein: a multifunctional viral regulator

2001 • 323 citations

Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas

2005 • 313 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

Viruses, Immunity, and Cancer: Lessons from Hepatitis B

2000 • 294 citations

HCV-associated liver cancer without cirrhosis

1995 • 293 citations

Classifying Hepatitis B Virus Genotypes

2003 • 288 citations

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.

1995 • 286 citations

OCCULT HEPATITIS B VIRUS INFECTION AND ITS CLINICAL IMPLICATIONS

2002 • 271 citations

Relationship Between Hepatocellular Carcinoma and Cirrhosis

1984 • 264 citations

Polymerase Chain Reaction to Detect Hepatitis B Virus DNA and RNA Sequences in Primary Liver Cancers from Patients Negative for Hepatitis B Surface Antigen

1990 • 261 citations

Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection?

1999 • 247 citations

HBx Protein of Hepatitis B Virus Activates Jak1-STAT Signaling

1998 • 230 citations

A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B

1990 • 229 citations

High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum

2000 • 216 citations

Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues.

2001 • 186 citations

Persistence of Hepatitis B and Hepatitis C Viral Genomes in Primary Liver Cancers from HBsAg-Negative Patients: A Study of a Low-endemic Area

1993 • 183 citations

Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels

2007 • 174 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

Clinical impact of occult HBV infections

2005 • 170 citations

Specific mutations of hepatitis B virus in plasma predict liver cancer development

2004 • 162 citations

Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma

2007 • 155 citations

Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum

1997 • 150 citations

Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients

1998 • 142 citations

Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis

1999 • 138 citations

Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients

2006 • 134 citations

Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma

2006 • 132 citations

Induction of the DNA-Binding Activity of c-Jun/c-Fos Heterodimers by the Hepatitis B Virus Transactivator pX

1994 • 127 citations

Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: Relevance of pregenome encapsidation signal

1992 • 120 citations

Integrated hepatitis B virus X and 3' truncated preS/S sequences derived from human hepatomas encode functionally active transactivators.

1994 • 119 citations

Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study

2004 • 103 citations

Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas

1999 • 100 citations

Hepatitis B virus surface antigen and polymerase gene variants: Potential virological and clinical significance

1998 • 91 citations

Sustained Activation of p38 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase Pathways by Hepatitis B Virus X Protein Mediates Apoptosis via Induction of Fas/FasL and Tumor Necrosis Factor (TNF) Receptor 1/TNF-α Expression

2004 • 89 citations

Viral load is a significant prognostic factor for hepatitis B virus‐associated hepatocellular carcinoma

2002 • 85 citations

Hepatocellular carcinoma development in cirrhosis

2007 • 82 citations

Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.

1994 • 80 citations

Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA

2005 • 77 citations

Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma

2006 • 75 citations

The PreS2 Activators of the Hepatitis B Virus: Activators of Tumour Promoter Pathways

1998 • 74 citations

Persistent occult hepatitis B virus infection: Experimental findings and clinical implications

2007 • 74 citations

Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: A key to the cell cycle and apoptosis

2005 • 71 citations

The hepatitis B virus pre-S/S(t) transactivator is generated by 3' truncations within a defined region of the S gene

1992 • 67 citations

Current pathogenetic and molecular concepts in viral liver carcinogenesis

1993 • 44 citations

A study on sequence variations in pre‐S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non‐B, non‐C hepatocellular carcinoma patients in Taiwan

2009 • 42 citations

Virological profiles in patients with chronic hepatitis C and overt or occult HBV infection

2002 • 42 citations

Erk-independent partial activation of AP-1 sites by the hepatitis B virus HBx protein.

1998 • 40 citations

Activation of calcium signaling by hepatitis B virus-X protein in liver cells

2003 • 40 citations

Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers

1996 • 36 citations

Hepatitis Virus-Related Hepatocarcinogenesis

1994 • 35 citations

Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection

2004 • 33 citations

Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma

2004 • 28 citations

Virological analysis, genotypes and mutational patterns of the HBV precore/core gene in HBV/HCV‐related hepatocellular carcinoma

2006 • 15 citations

Trend of liver cirrhosis as precancerous lesions

2002 • 13 citations

Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus

2007 • 10 citations

Low replication and variability of HBV pre-core in concomitant infection with hepatitis B and hepatitis C viruses

2006 • 7 citations

Deleted Work

1955 • 0 citations