A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B

Viral Hepatitis and Liver Disease

1985 • 1,886 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1989 • 1,210 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

1979 • 992 citations

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

1988 • 814 citations

Hepatitis B virus genes and their expression in E. coli

1979 • 584 citations

Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection

1980 • 433 citations

Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw

1983 • 426 citations

Analysis of Liver Disease, Nuclear HBcAg, Viral Replication, and Hepatitis B Virus DNA in Liver and Serum of HBcAg Vs. Anti-HBe Positive Carriers of Hepatitis B Virus

1983 • 385 citations

Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen.

1986 • 345 citations

Chronic hepatitis in HBsAg carriers with serum HBV-DNA and Anti-HBe

1986 • 334 citations

Chronic type B hepatitis and the “healthy” Hbsag carrier state

1987 • 295 citations

Hepatitis B virus DNA in the sera of HBsAg carriers: A marker of active hepatitis B virus replication in the liver

1981 • 285 citations

THE NUCLEOTIDE SEQUENCE OF THE HEPATITIS B VIRAL GENOME AND THE IDENTIFICATION OF THE MAJOR VIRAL GENES

1980 • 277 citations

Viral hepatitis and liver disease

1989 • 275 citations

Identification of HBV variants which cannot produce pre-core derived HBeAg and may be responsible for severe hepatitis

1989 • 263 citations

Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigen

1989 • 229 citations

Identification of a novel herpes simplex virus type 1-induced glycoprotein which complexes with gE and binds immunoglobulin

1987 • 200 citations

The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation

1987 • 182 citations

Expression of the precore region of an avian hepatitis B virus is not required for viral replication

1987 • 166 citations

Long-term follow-up of anti-HBe-positive chronic active hepatitis B

1988 • 138 citations

The hepatitis delta virus and its infection

1987 • 125 citations

The Complete Nucleotide Sequence of the Genome of a Hepatitis B Virus Isolated from a Naturally Infected Chimpanzee

1988 • 125 citations

Contribution of low level HBV replication to continuing inflammatory activity in patients with anti-HBe positive chronic hepatitis B virus infection.

1984 • 121 citations

Precore sequence of hepatitis B virus inducing e antigen and membrane association of the viral core protein

1986 • 114 citations

Expression of the hepatitis B virus core gene in vitro and in vivo

1987 • 83 citations

Detection and characterization of hepatitis B virus DNA in serum of HBe antigen‐negative HBsAg carriers

1984 • 54 citations

Animal hepatitis B viruses

1989 • 43 citations

The importance of hepatitis B viral DNA in serum and liver

1986 • 34 citations

Relationship between the intrahepatic expression of 'e' and 'c' epitopes of the nucleocapsid protein of hepatitis B virus and viraemia.

1989 • 16 citations

Presence of hepatitis B virus-deoxyribonucleic acid in human tissues under unexpected circumstances

1985 • 16 citations

Structure and function of the hepatitis B virus genome.

1982 • 14 citations

Results of liver transplantation for liver disease due to hepatitis B virus (HBV) infection

1989 • 4 citations