Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

An Animal Model for Cystic Fibrosis Made by Gene Targeting

1992 • 921 citations

Cystic fibrosis: molecular biology and therapeutic implications

1992 • 820 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

1993 • 669 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

1991 • 348 citations

Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice

1993 • 345 citations

Common Control of the Heat Shock Gene and Early Adenovirus Genes: Evidence for a Cellular E1A-like Activity

1984 • 331 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Toxicity Study

1993 • 324 citations

Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy

1993 • 310 citations

Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses

1993 • 303 citations

Selection and Preliminary Characterization of Temperature-Sensitive Mutants of Type 5 Adenovirus

1972 • 248 citations

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.

1985 • 234 citations

Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection.

1984 • 234 citations

Safety and efficacy of repetitive adenovirus–mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats

1994 • 216 citations

Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.

1993 • 199 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Biological Efficacy Study

1993 • 196 citations

Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis

1984 • 186 citations

Cis-acting induction of adenovirus transcription

1983 • 180 citations

Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus)

1993 • 173 citations

Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity.

1984 • 142 citations

Infection of Mouse Liver by Human Adenovirus Type 5

1978 • 121 citations

NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A

1992 • 95 citations

Role of early genes in pathogenesis of adenovirus pneumonia.

1990 • 81 citations

The murine cellular immune response to adenovirus type 5

1989 • 57 citations

Vehicles for gene therapy

1993 • 50 citations

Multiple Functions of the Adenovirus DNA-Binding Protein Are Required for Efficient Viral DNA Synthesis

1993 • 17 citations