Molecular analysis of the C. elegans sex-determining gene tra-1: A gene encoding two zinc finger proteins

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

The Nematode Caenorhabditis elegans

1988 • 2,868 citations

[1] Production of single-stranded plasmid DNA

1987 • 2,642 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

Potential Metal-Binding Domains in Nucleic Acid Binding Proteins

1986 • 1,096 citations

Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

1991 • 871 citations

NONDISJUNCTION MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1979 • 768 citations

Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides

1989 • 685 citations

‘Zinc fingers’: a novel protein motif for nucleic acid recognition

1987 • 676 citations

Toward a physical map of the genome of the nematode Caenorhabditis elegans

1986 • 631 citations

The Caenorhabditis elegans male: Postembryonic development of nongonadal structures

1980 • 588 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylationin vitro

1990 • 498 citations

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

1990 • 478 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

1986 • 409 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

How the messenger got its tail: addition of poly(A) in the nucleus

1990 • 390 citations

Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila

1991 • 333 citations

Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript

1990 • 333 citations

MUTATIONS CAUSING TRANSFORMATION OF SEXUAL PHENOTYPE IN THE NEMATODE CAENORHABDITIS ELEGANS

1977 • 253 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans

1988 • 235 citations

[66] Mapping of gene transcripts by nuclease protection assays and cDNA primer extension

1987 • 228 citations

Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript

1991 • 224 citations

Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox.

1988 • 219 citations

A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans

1984 • 216 citations

SEX DETERMINATION IN THE NEMATODE C. ELEGANS: ANALYSIS OF tra-3 SUPPRESSORS AND CHARACTERIZATION OF fem GENES

1986 • 210 citations

Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression

1987 • 204 citations

The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer.

1991 • 201 citations

A multigene family encoding several “finger” structures is present and differentially active in mammalian genomes

1987 • 197 citations

A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans.

1987 • 196 citations

POLYPLOIDS AND SEX DETERMINATION IN CAENORHABDITIS ELEGANS

1979 • 194 citations

Nucleic acid and protein sequence analysis: a practical approach

1988 • 180 citations

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

1990 • 180 citations

The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions

1990 • 176 citations

MORE SEX-DETERMINATION MUTANTS OF CAENORHABDITIS ELEGANS

1980 • 166 citations

Sex determination compared in Drosophila and Caenorhabditis

1990 • 165 citations

The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice.

1989 • 164 citations

xol-1: A gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegans

1988 • 163 citations

Actin gene family of Caenorhabditis elegans

1983 • 156 citations

Caenorhabditis elegans compensates for the difference in X chromosome dosage between the sexes by regulating transcript levels

1986 • 154 citations

Intersex, a temperature-sensitive mutant of the nematode Caenorhabditis elegans

1978 • 151 citations

A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans.

1989 • 149 citations

Specification of male development in Caenorhabditis elegans: The fem genes

1984 • 131 citations

tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.

1992 • 127 citations

Cloning of a yolk protein gene family from Caenorhabditis elegans

1984 • 108 citations

Linear amplification sequencing, a powerful method for sequencing DNA

1991 • 97 citations

A finger protein structurally similar to TFIIIA that binds exclusively to 5S RNA in Xenopus

1990 • 97 citations

The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally.

1992 • 96 citations

Analysis of the role of tra-1 in germline sex determination in the nematode Caenorhabditis elegans.

1989 • 94 citations

The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals.

1989 • 86 citations

Evidence from mosaic analysis of the masculinizing gene her–1for cell interactions inC. eleganssex determination

1992 • 81 citations

sdc-1: A link between sex determination and dosage compensation in C. elegans

1987 • 80 citations

SEX DETERMINATION AND DOSAGE COMPENSATION IN CAENORHABDITIS ELEGANS

1987 • 80 citations

Sex-specific transcriptional regulation of the C. elegans sex-determining gene her-1

1991 • 80 citations

Two types of sex determination in a nematode

1983 • 69 citations

Molecular cloning and transcript analysis of fem-3, a sex-determination gene in Caenorhabditis elegans.

1988 • 67 citations

The tra-1 gene determines sexual phenotype cell-autonomously in C. elegans

1990 • 67 citations

Molecular analysis of tra-2, a sex determining gene in C.elegans.

1991 • 65 citations

Sequence-specific DNA binding by a two zinc-finger peptide from the Drosophila melanogaster tramtrack protein

1992 • 64 citations

The Regulatory Hierarchy Controlling Sex Determination And Dosage Compensation IN

1990 • 64 citations

Early aspects of Caenorhabditis elegans sex determination and dosage compensation are regulated by a zinc-finger protein

1991 • 64 citations

A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts.

1987 • 63 citations

Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs.

1990 • 57 citations

Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues

1991 • 56 citations

9 Sexual Dimorphism and Sex Determination

1988 • 52 citations

A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans.

1988 • 46 citations

Polyadenylation precedes splicing in vitro.

1991 • 33 citations

Specific DNA binding to a major histocompatibility complex enhancer sequence by a synthetic 57-residue double zinc finger peptide from a human enhancer binding protein.

1991 • 18 citations