Cellular Defense Mechanisms Against Alkylation of DNA

Rate of depurination of native deoxyribonucleic acid

1972 • 1,488 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Suicide enzyme inactivators

1976 • 366 citations

All oxygens in nucleic acids react with carcinogenic ethylating agents

1976 • 311 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

New class of enzymes acting on damaged DNA

1976 • 259 citations

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

1979 • 257 citations

[26] Exonuclease III of Escherichia coli K-12, an AP endonuclease

1980 • 243 citations

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

1977 • 225 citations

A new endonuclease from Escherichia coli acting at apurinic sites in DNA.

1977 • 225 citations

Chromosome Damage and Repair

1981 • 219 citations

Properties of 3-methyladenine-DNA glycosylase from Escherichia coli

1978 • 190 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N′-nitro-N-nitrosoguanidine

1970 • 173 citations

Apurinic/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA.

1980 • 163 citations

Two enzymes are required for strand incision in repair of alkylated DNA

1977 • 153 citations

Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase

1980 • 146 citations

Quantitation of the adaptive response to alkylating agents

1979 • 145 citations

Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts.

1981 • 142 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladenines.

1981 • 121 citations

1009. The methylation of guanosine and related compounds with diazomethane

1962 • 116 citations

Nuclease for DNA Apurinic Sites May be Involved in the Maintenance of DNA in Normal Cells

1973 • 103 citations

Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.

1980 • 99 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Repair of O6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein.

1981 • 89 citations

Removal of minor methylation products 7-methyl adenine and 3-methylguanine from DNA ofescherichia coli treated with dimethyl sulphate

1976 • 84 citations

The Inducible Repair of Alkylated DNA

1981 • 70 citations

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

1981 • 69 citations

Efficiency of the adaptive response of Escherichia coli to alkylating agents

1980 • 61 citations

Enzymic excision of 3-methyladenine and 7-methylguanine by a rat liver nuclear fraction

1981 • 58 citations

Release of 7-methylguanine residues from alkylated DNA by extracts of Micrococcus luteus and Escherichia coli.

1981 • 55 citations

Partial purification and characterization of a human 3-methyladenine-DNA glycosylase

1979 • 54 citations

The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects

1980 • 49 citations

Non‐enzymatic methylation of proteins with S‐adenosyl‐L‐methionine

1975 • 30 citations

Mechanism of potent mutagenic action of N-Methyl-N′-nitro-N-nitrosoguanidine on intracellular phage Lambda

1978 • 28 citations

Actions of human DNA glycosylases on uracil-containing DNA, methylated DNA and their reconstituted chromatins

1979 • 17 citations