ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

2004 • 976 citations

P-Glycoprotein, a gatekeeper in the blood–brain barrier

1999 • 918 citations

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

2001 • 722 citations

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

2000 • 611 citations

The SLC22 drug transporter family

2004 • 519 citations

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

2002 • 479 citations

(Section A: Molecular, Structural, and Cellular Biology of Drug Transporters) The MRP-Related and BCRP / ABCG2 Multidrug Resistance Proteins: Biology, Substrate Specificity and Regulation

2004 • 477 citations

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

2000 • 473 citations

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

2004 • 407 citations

Localisation of breast cancer resistance protein in microvessel endothelium of human brain

2002 • 405 citations

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier.

2000 • 399 citations

Transport of Cyclic Nucleotides and Estradiol 17-β-d-Glucuronide by Multidrug Resistance Protein 4

2001 • 389 citations

Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain

2004 • 369 citations

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

2003 • 349 citations

ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS

2004 • 311 citations

Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

2002 • 307 citations

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

2004 • 275 citations

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.

1995 • 230 citations

Analysis of the MRP4 Drug Resistance Profile in Transfected NIH3T3 Cells

2000 • 227 citations

Active efflux across the blood-brain barrier: Role of the solute carrier family

2004 • 224 citations

Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced Damage

1998 • 200 citations

Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors

2003 • 198 citations

Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors

1999 • 189 citations

Localization of Breast Cancer Resistance Protein (BCRP) in Microvessel Endothelium of Human Control and Epileptic Brain

2005 • 175 citations

Plasma Membrane Localization of Multidrug Resistance-Associated Protein Homologs in Brain Capillary Endothelial Cells

2004 • 174 citations

Thiopurine Metabolism and Identification of the Thiopurine Metabolites Transported by MRP4 and MRP5 Overexpressed in Human Embryonic Kidney Cells

2002 • 174 citations

Functional expression of p-glycoprotein and multidrug resistance-associated protein (mrp1) in primary cultures of rat astrocytes

2000 • 156 citations

Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood–brain barrier

2004 • 146 citations

Anticancer drug resistance in primary human brain tumors

2001 • 142 citations

Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones

2002 • 133 citations

Expression of MRP4 Confers Resistance to Ganciclovir and Compromises Bystander Cell Killing

2002 • 119 citations

Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes.

2002 • 97 citations

Expression of multidrug resistance protein gene in patients with glioma after chemotherapy.

1998 • 94 citations

Molecular changes in gliomas

2004 • 89 citations

Molecular and functional MDR1‐Pgp and MRPs expression in human glioblastoma multiforme cell lines

2002 • 86 citations

The multidrug-resistance gene MDR1 is expressed in human glial tumors

1991 • 71 citations

Expression of multidrug resistance-associated protein (MRP) in human gliomas.

2000 • 71 citations

Multidrug Resistance-Associated Protein MRP1 Expression in Human Gliomas: Chemosensitization to Vincristine and Etoposide by Indomethacin in Human Glioma Cell Lines Overexpressing MRP1

2004 • 65 citations

Drug resistance-associated factors in primary and secondary glioblastomas and their precursor tumors.

2000 • 65 citations

Immunolocalization of Multidrug Resistance Protein 5 in the Human Genitourinary System

2002 • 54 citations

Involvement of the Multidrug Resistance Protein 3 in Drug Sensitivity and Its Expression in Human Glioma

2001 • 52 citations

Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors

1999 • 52 citations

P‐Glycoprotein and Multidrug Resistance‐associated Protein Mediate Specific Patterns of Multidrug Resistance in Malignant Glioma Cell Lines, but not in Primary Glioma Cells

2003 • 48 citations

Heterogeneity in the expression of markers for drug resistance in brain tumors.

2004 • 47 citations

Molecular Markers that Identify Human Astrocytomas and Oligodendrogliomas

2002 • 43 citations

Neuro-oncology: the growing role of chemotherapy in glioma

2004 • 39 citations

The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity

2003 • 37 citations

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