The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity

Prospective identification of tumorigenic breast cancer cells

2003 • 10,067 citations

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

2002 • 2,028 citations

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

The WHO Classification of Tumors of the Nervous System

2002 • 1,931 citations

Specific Genetic Predictors of Chemotherapeutic Response and Survival in Patients With Anaplastic Oligodendrogliomas

1998 • 1,611 citations

Cell fusion is the principal source of bone-marrow-derived hepatocytes

2003 • 1,575 citations

Changing potency by spontaneous fusion

2002 • 1,525 citations

Neurogenesis in Adult Subventricular Zone

2002 • 1,415 citations

Pathology and genetics of tumours of the nervous system.

2000 • 1,374 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection

2002 • 1,024 citations

The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

2002 • 1,024 citations

Human cortical glial tumors contain neural stem‐like cells expressing astroglial and neuronal markers in vitro

2002 • 964 citations

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.

2003 • 952 citations

Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System

2000 • 839 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

Pathology and Genetics of Tumours of the Nervous System

2001 • 820 citations

Identification of a Novel Family of Oligodendrocyte Lineage-Specific Basic Helix–Loop–Helix Transcription Factors

2000 • 786 citations

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

2001 • 708 citations

The oligodendrocyte precursor cell in health and disease

2001 • 654 citations

Epidermal growth factor receptor and Ink4a/Arf

2002 • 647 citations

The Basic Helix-Loop-Helix Factor Olig2 Is Essential for the Development of Motoneuron and Oligodendrocyte Lineages

2002 • 483 citations

Identification of an adult-specific glial progenitor cell

1989 • 476 citations

Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant

2003 • 448 citations

Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis.

2001 • 427 citations

A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.

1996 • 407 citations

Patient age, histologic features, and length of survival in patients with glioblastoma multiforme

1987 • 388 citations

Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3

2000 • 376 citations

Successful chemotherapy for recurrent malignant oligodendroglioma

1988 • 346 citations

A tripotential glial precursor cell is present in the developing spinal cord

1998 • 311 citations

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

2002 • 286 citations

Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.

2001 • 271 citations

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

1996 • 251 citations

Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms.

2001 • 232 citations

The Chemokine Growth-Regulated Oncogene-α Promotes Spinal Cord Oligodendrocyte Precursor Proliferation

1998 • 227 citations

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

1988 • 220 citations

Impact of Genotype and Morphology on the Prognosis of Glioblastoma

2002 • 211 citations

Genetic Signature of Oligoastrocytomas Correlates with Tumor Location and Denotes Distinct Molecular Subsets

2002 • 180 citations

An ‘oligarchy’ rules neural development

2002 • 176 citations

Genetic determinants of malignancy in a mouse model for oligodendroglioma.

2003 • 175 citations

Oligodendrocyte and astrocyte development in rodents: An in situ and immunohistological analysis during embryonic development

2002 • 168 citations

Oligodendrocyte lineage genes ( OLIG ) as molecular markers for human glial brain tumors

2001 • 168 citations

Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor species

2002 • 151 citations

Melanoma x macrophage hybrids with enhanced metastatic potential.

1997 • 147 citations

In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells.

1992 • 144 citations

OLIG2 as a specific marker of oligodendroglial tumour cells

2001 • 140 citations

Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.

2003 • 137 citations

Glucose Metabolism in Cancer

2003 • 137 citations

Successful chemotherapy for newly diagnosed aggressive oligodendroglioma

1990 • 136 citations

Immortalization and transformation are associated with specific alterations in choline metabolism.

1996 • 134 citations

The Tripotential Glial-Restricted Precursor (GRP) Cell and Glial Development in the Spinal Cord: Generation of Bipotential Oligodendrocyte-Type-2 Astrocyte Progenitor Cells and Dorsal–Ventral Differences in GRP Cell Function

2002 • 122 citations

Treatment options for central neurocytoma

2002 • 100 citations

Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas–Implications for tumor biology and potential clinical utility

2001 • 93 citations

Shared oligodendrocyte lineage gene expression in gliomas and oligodendrocyte progenitor cells

2003 • 90 citations

Differential expression of drug resistance genes and chemosensitivity in glial cell lineages correlate with differential response of oligodendrogliomas and astrocytomas to chemotherapy.

2000 • 90 citations

Oligodendrocyte Precursor Cells from Different Brain Regions Express Divergent Properties Consistent with the Differing Time Courses of Myelination in These Regions

2002 • 88 citations

Getting a GR(i)P on oligodendrocyte development

2003 • 77 citations

The subpopulations and isolated cell types of freshly resected high grade human gliomas: Their influence on the tumor's evolutionin vivo and behavior and therapyin vitro

1985 • 73 citations

Cytogenetic and flow cytometry DNA analysis of regional heterogeneity in a low grade human glioma.

1995 • 67 citations

Acquisition of high metastatic capacity after in vitro fusion of a nonmetastatic tumor line with a bone marrow-derived macrophage.

1984 • 64 citations

Aberrant methylation of genes in low-grade astrocytomas

2000 • 62 citations

DNA methylation in brain development and gliomagenesis

2003 • 51 citations

Using Mice to Decipher the Molecular Genetics of Brain Tumors

2003 • 50 citations

From rodent glial precursor cell to human glial neoplasia in the oligodendrocyte‐type‐2‐astrocyte lineage

1995 • 49 citations

Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma

2003 • 48 citations

Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas

2001 • 47 citations

Clonal Tumor Cell Heterogeneity1

2015 • 47 citations

Molecular Markers that Identify Human Astrocytomas and Oligodendrogliomas

2002 • 43 citations

Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells transformed with c-myc and H-ras form high-grade glioma after stereotactic injection into the rat brain

1998 • 42 citations

Extensive intra-tumor heterogeneity in primary human glial tumors as a result of locus non-specific genomic alterations.

2000 • 34 citations

The Cortical Ancestry of Oligodendrocytes: Common Principles and Novel Features

2003 • 31 citations

Genetic Modeling of Glioma Formation in Mice

2002 • 27 citations

Genetic heterogeneity and progression in different areas within high-grade diffuse astrocytoma.

2000 • 12 citations