P‐Glycoprotein and Multidrug Resistance‐associated Protein Mediate Specific Patterns of Multidrug Resistance in Malignant Glioma Cell Lines, but not in Primary Glioma Cells

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults

1993 • 872 citations

The multidrug resistance protein family

1999 • 654 citations

P-glycoprotein and multidrug resistance

1996 • 549 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 358 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 312 citations

Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

1998 • 265 citations

Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

1998 • 202 citations

Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses

1998 • 171 citations

Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier

1997 • 144 citations

Malignant glioma: Who benefits from adjuvant chemotherapy?

1998 • 132 citations

MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors.

1996 • 117 citations

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis

1999 • 112 citations

What have we learnt thus far from mice with disrupted P-glycoprotein genes?

1996 • 109 citations

Expression of multidrug resistance protein gene in patients with glioma after chemotherapy.

1998 • 94 citations

Possible involvement of multidrug‐resistance‐associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells

1994 • 89 citations

Molecular and functional MDR1‐Pgp and MRPs expression in human glioblastoma multiforme cell lines

2002 • 86 citations

P-glycoprotein expression in brain tumors

1992 • 83 citations

The multidrug-resistance gene MDR1 is expressed in human glial tumors

1991 • 71 citations

Selective Potentiation of Drug Cytotoxicity by NSAID in Human Glioma Cells: The Role of COX-1 and MRP

1999 • 58 citations

Expression of P-glycoprotein in human glioma cell lines and surgical glioma specimens

1991 • 56 citations

Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas

1994 • 53 citations

Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia

1997 • 45 citations

Murine P-glycoprotein on stromal vessels mediates multidrug resistance in intracerebral human glioma xenografts

1997 • 37 citations

The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia

1998 • 30 citations

Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma?

1999 • 23 citations

Evidence for a constitutive, verapamil-sensitive, non-P-glycoprotein multidrug resistance phenotype in malignant glioma that is unaltered by radiochemotherapy in vivo

2000 • 20 citations

Differences in multidrug resistance phenotype and matrix metalloproteinases activity between endothelial cells from normal brain and glioma

2003 • 16 citations

Reversal of chemoresistance in malignant gliomas by calcium antagonists: correlation with the expression of multidrug-resistant p-glycoprotein

1994 • 15 citations