Bcl-2 Overexpression Does Not Prevent but Retards Adriamycin Toxicity in CC531 Colon Carcinoma Cells

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

1999 • 2,156 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

1993 • 855 citations

Bcl-2 Gene Family and the Regulation of Programmed Cell Death

1994 • 725 citations

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

1999 • 708 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

1997 • 343 citations

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

2000 • 336 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.

1990 • 223 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells

1997 • 153 citations

BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells.

1995 • 144 citations

Bcl-2 Family Proteins: Strategies for Overcoming Chemoresistance in Cancer

1997 • 127 citations

Expression of Bcl-2 Increases Intracellular Glutathione by Inhibiting Methionine-Dependent GSH Efflux

1998 • 93 citations

Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity

1998 • 82 citations

Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma

1999 • 75 citations

Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells

1997 • 72 citations

Protection against hydrogen peroxide cytotoxicity in Rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione

1999 • 46 citations

Cell line dependence of Bcl-2-induced alteration of glutathione handling

2000 • 35 citations

Suppression of transcription factor NF-κB activity by Bcl-2 protein in NIH3T3 cells: implication of a novel NF-κB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2

2000 • 28 citations

Development of resistance to glutathione depletion-induced cell death in CC531 colon carcinoma cells: association with increased expression of Bcl-2

2000 • 26 citations

Expression of Bcl-2 in human epithelial tumor (HeLa) cells enhances clonogenic survival following exposure to 5-fluoro-2′-deoxyuridine or staurosporine, but not following exposure to etoposide or doxorubicin

1998 • 22 citations

Protection against hydrogen peroxide cytotoxicity in Rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione

1999 • 22 citations

The role of various Bcl‐2 domains in the anti‐proliferative effect and modulation of cellular glutathione levels: a prominent role for the BH4 domain

2003 • 19 citations

Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha.

1998 • 12 citations

Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma

1999 • 6 citations