Development of resistance to glutathione depletion-induced cell death in CC531 colon carcinoma cells: association with increased expression of Bcl-2

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Tissue sulfhydryl groups

1959 • 25,130 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis.

1995 • 239 citations

Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

1997 • 223 citations

Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione

1987 • 209 citations

Interferon treatment of a transplantable rat colon adenocarcinoma: Importance of tumor site

1984 • 185 citations

Fas‐mediated apoptosis is modulated by intracellular glutathione in human T cells

1996 • 169 citations

Quantification of apoptotic cells with fluorescein isothiocyanate-labeled annexin V in chinese hamster ovary cell cultures treated with cisplatin

1996 • 158 citations

Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways.

1997 • 109 citations

Glutathione depletion in fibroblasts is the basis for apoptosis-induction by endogenous reactive oxygen species

1997 • 62 citations

APOPTOTIC AN IN AN IN VITRO MODEL OF NEURONAL OXIDATIVE STRESS

1995 • 54 citations

Buthionine sulphoximine alone and in combination with melphalan (L-PAM) is highly cytotoxic for human neuroblastoma cell lines

1997 • 41 citations

Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells

1999 • 39 citations

Upregulation of Intracellular Glutathione by Fibroblast-Derived Factor(s): Enhanced Survival of Activated T Cells in the Presence of Low Bcl-2

1997 • 32 citations

Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione.

1993 • 30 citations

Increasing the effective concentration of melphalan in experimental rat liver tumours: comparison of isolated liver perfusion and hepatic artery infusion

1991 • 30 citations

Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury.

1995 • 26 citations

Involvement of intracellular glutathione in induction of apoptosis by cisplatin in a human pharyngeal carcinoma cell line.

1996 • 24 citations

Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the ratin vivo and in the perfused rat liver

1995 • 22 citations

In VivoCharacterization and Modulation of the Glutathione/GlutathioneS-Transferase System in Cancer Patients

1995 • 21 citations

Evidence against the hypothesis that BCL-2 inhibits apoptosis through an anti-oxidant effect

1997 • 17 citations

Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat

1999 • 15 citations

Lack of glutathione conjugation of melphalan in the isolated in situ liver perfusion in humans.

1996 • 15 citations

Applications in renal immunopathology of reflection contrast microscopy, a novel superior light microscopical technique

1996 • 10 citations

Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver

1995 • 10 citations