β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

International Histological Classification of Tumours

1981 • 2,045 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

1998 • 1,200 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

1998 • 846 citations

β-catenin: a key mediator of Wnt signaling

1998 • 746 citations

Overexpression of the EGF Receptor and p53 Mutations are Mutually Exclusive in the Evolution of Primary and Secondary Glioblastomas

1996 • 733 citations

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

1997 • 702 citations

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

1997 • 679 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

The oncogenic activation of β-catenin

1999 • 655 citations

A common human skin tumour is caused by activating mutations in β-catenin

1999 • 608 citations

Hepatitis C and hepatocellular carcinoma

1997 • 565 citations

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

1992 • 562 citations

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

1997 • 543 citations

Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.

1998 • 441 citations

APC gene: database of germline and somatic mutations in human tumors and cell lines

1996 • 428 citations

Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

1996 • 412 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

1999 • 398 citations

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1998 • 395 citations

Beta-catenin mutation in carcinoma of the uterine endometrium.

1998 • 370 citations

Beta-catenin mutations in human prostate cancer.

1998 • 368 citations

Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.

1998 • 350 citations

Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma.

1994 • 327 citations

Frequent mutation and nuclear localization of betacatenin in anaplastic thyroid carcinoma

1999 • 303 citations

Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations.

1998 • 276 citations

Transcriptional Repression of p53 Promoter by Hepatitis C Virus Core Protein

1997 • 274 citations

Suppression of Apoptotic Cell Death by Hepatitis C Virus Core Protein

1996 • 268 citations

Hepatocellular Carcinoma: From Gene to Public Health

1997 • 267 citations

The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas

1997 • 254 citations

p53 gene mutation spectrum in hepatocellular carcinoma.

1992 • 249 citations

Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.

1999 • 227 citations

Allelotype study of primary hepatocellular carcinoma

1991 • 223 citations

Frequent somatic mutations of the APC gene in human pancreatic cancer.

1992 • 213 citations

Histological Typing of Tumours of the Liver

1994 • 174 citations

Hepatitis b Viruses and Hepatocellular Carcinoma

1992 • 142 citations

Pathogenesis of hepatitis B and C‐induced hepatocellular carcinoma

1998 • 132 citations

Etiology, pathology, and treatment of hepatocellular carcinoma in North America

1991 • 123 citations

APC gene: database of germline and somatic mutations in human tumors and cell lines

1998 • 122 citations

Hepatitis C Virus and Hepatocellular Carcinoma

1999 • 103 citations

Clonal analysis of regenerative nodules in hepatitis C virus-induced liver cirrhosis

1994 • 84 citations

Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance.

1993 • 74 citations

Loss of constitutional heterozygosity on chromosome 5q in hepatocellular carcinoma without cirrhosis

1991 • 70 citations

Hepatitis C virus infection as a major risk factor for hepatocellular carcinoma.

1996 • 69 citations

Frequent β‐Catenin Abnormalities in Bone and Soft‐tissue Tumors

1999 • 61 citations

p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese.

1994 • 56 citations

Multiple hepatocellular carcinomas at the early stage have different clonality

1993 • 53 citations

Molecular mechanism of hepatocarcinogenesis

1997 • 46 citations

Hepatocellular carcinoma and hepatitis B virus infection: molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes

1987 • 28 citations

Hepatitis B and C viruses and primary liver cancer

1996 • 22 citations

Clonality in hepatocellular carcinoma: Analysis of methylation pattern of polymorphic X–chromosome-linked phosphoglycerate kinase gene in females

1995 • 21 citations

The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes.

1993 • 17 citations

Pathology of Viral Hepatitis

1999 • 9 citations

Pathology of viral hepatitis.

1979 • 9 citations