Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1979 • 1,305 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE.

1991 • 931 citations

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

1997 • 702 citations

Primary hepatic tumors of childhood

1983 • 494 citations

Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.

1998 • 441 citations

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1998 • 395 citations

Mutations of theAPC adenomatous polyposis coli) gene

1993 • 392 citations

Beta-catenin mutations in human prostate cancer.

1998 • 368 citations

Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.

1998 • 350 citations

Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations.

1998 • 276 citations

Effects of Forced Expression of an NH2-terminal Truncated β-Catenin on Mouse Intestinal Epithelial Homeostasis

1998 • 183 citations

Hepatoblastoma and APC gene mutation in familial adenomatous polyposis.

1996 • 161 citations

Carcinogenesis: A balance between β-catenin and APC

1997 • 154 citations

Somatic mutations of the APC gene in sporadic hepatoblastomas.

1996 • 144 citations

Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.

1976 • 128 citations

Loss of maternal alleles on chromosome arm 11p in hepatoblastoma.

1994 • 110 citations

Biallelic inactivation of the APC gene in hepatoblastoma.

1995 • 95 citations

Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma.

1996 • 72 citations

Microsatellite analysis of loss of heterozygosity on chromosomes 9q, 11 p and 17p in medulloblastomas

1994 • 72 citations

Loss of heterozygosity on chromosome 1 in human hepatoblastoma

1996 • 46 citations