Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

1974 • 8,693 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

Sodium butyrate inhibits histone deacetylation in cultured cells

1978 • 1,008 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

A direct link between core histone acetylation and transcriptionally active chromatin.

1988 • 905 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

Structure of nucleosome core particles of chromatin

1977 • 746 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

1992 • 552 citations

Alternative chromatin structure at CpG islands

1990 • 480 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

Processing of Newly Synthesized Histone Molecules

1975 • 434 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Different accessibilities in chromatin to histone acetylase.

1979 • 340 citations

Histones of Drosophila Embryos

1974 • 339 citations

Non-allelic variants of histones 2a, 2b and 3 in mammals

1977 • 332 citations

Histone acetylation and control of gene expression

1991 • 331 citations

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

1992 • 297 citations

Participation of core histone "tails" in the stabilization of the chromatin solenoid.

1982 • 264 citations

On the biological role of histone acetylation

1990 • 246 citations

Recent insights in phosphatidylinositol signaling

1990 • 245 citations

Modifications to histones immediately after synthesis

1976 • 201 citations

Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo.

1992 • 186 citations

Manifold effects of sodium butyrate on nuclear function. Selective and reversible inhibition of phosphorylation of histones H1 and H2A and impaired methylation of lysine and arginine residues in nuclear protein fractions.

1981 • 179 citations

Phosphorylation of histones 1 and 3 and nonhistone high mobility group 14 by an endogenous kinase in HeLa metaphase chromosomes.

1982 • 167 citations

Complexity of the Early Genetic Response to Growth Factors in Mouse Fibroblasts

1988 • 159 citations

Patterns of histone acetylation

1990 • 151 citations

A comprehensive compilation and alignment of histones and histone genes

1989 • 149 citations

Rapid and reversible changes in nucleosome structure accompany the activation, repression, and superinduction of murine fibroblast protooncogenes c-fos and c-myc.

1987 • 125 citations

A Poly(dA-dT) Upstream Activating Sequence Binds High-Mobility Group I Protein and Contributes to Lymphotoxin (Tumor Necrosis Factor-β) Gene Regulation

1992 • 115 citations

Agonist-induced Calcium Oscillations in Depolarized Fibroblasts and Their Manipulation by Photoreleased Ins(l,4,5)P3, and Ca++, and Ca++ Buffer

1988 • 89 citations

Mitosis‐specific histone H3 phosphorylation in vitro in nucleosome structures

1990 • 76 citations

Yeast may not contain histone H1: the only known ‘histone H1-like’ protein inSaccharomyces cerevisiaeis a mitochondrial protein

1984 • 75 citations

Calcium-dependent phosphorylation of histone H3 in butyrate-treated HeLa cells

1980 • 70 citations

Effects of histone acetylation on chromatin topology in vivo.

1992 • 62 citations

[25] Analysis of histone subtypes and their modified forms by polyacrylamide gel electrophoresis

1989 • 59 citations

Acetylation and calcium-dependent phosphorylation of histone H3 in nuclei from butyrate-treated HeLa cells.

1983 • 57 citations

Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6.

1990 • 57 citations

Histone acetylation in baker's yeast. Maintenance of the hyperacetylated configuration in log phase protoplasts.

1982 • 56 citations

Effects of butyric acid on cell cycle regulation and induction of histone H1 ∘ in mouse cells and tissue culture

1985 • 52 citations

The separation of transcriptionally engaged genes.

1988 • 51 citations

Tyrosine kinases and their interactions with signalling proteins

1992 • 51 citations

Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction.

1994 • 45 citations

2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C.

1990 • 44 citations

The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression

1989 • 42 citations

Serum stimulation of the c-fos enhancer induces reversible changes in c-fos chromatin structure.

1990 • 41 citations

Dynamically acetylated histones of chicken erythrocytes are selectively methylated

1991 • 39 citations

Role of histones H1 and H3 in the maintenance of chromatin in a compact conformation

1983 • 37 citations

Signal Transduction in Mitogenesis: Further Evidence for Multiple Pathways

1988 • 35 citations

H3 phosphorylation-dependent structural changes in chromatin

1987 • 23 citations

Effects of Histone Acetylation on Chromatin Topology In Vivo

1992 • 15 citations

2-Aminopurine abolishes epidermal growth factor-stimulated phosphorylation of complexed and chromatin-associated forms of a 33 kDa phosphoprotein.

1989 • 14 citations

Serum Stimulation of the c-fos Enhancer Induces Reversible Changes in c-fos Chromatin Structure

1990 • 8 citations

Anisomycin and Rapamycin Define an Area Upstream of p70/85^S6k Containing a Bifurcation to Histone H3-HMG-Like Protein Phosphorylation and c-fos-c-jun Induction

1994 • 7 citations