Innate Immunity and Inflammation: A Transcriptional Paradigm

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

1990 • 796 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

1993 • 563 citations

Susceptibility to Infection and Altered Hematopoiesis in Mice Deficient in Both P- and E-Selectins

1996 • 534 citations

Role of PSGL-1 binding to selectins in leukocyte recruitment.

1997 • 491 citations

Role of NFkappaB in the mortality of sepsis.

1997 • 464 citations

Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice

1998 • 357 citations

A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice.

1991 • 298 citations

Interferon gamma receptor deficient mice are resistant to endotoxic shock.

1994 • 293 citations

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

1997 • 275 citations

Regulation of the tissue factor gene

1995 • 275 citations

Regulation of the Tissue Factor Gene

1997 • 270 citations

The Biology of P-Selectin Glycoprotein Ligand-1: Its Role as a Selectin Counterreceptor in Leukocyte-Endothelial and Leukocyte-Platelet Interaction

1999 • 251 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

Superantigens: Bacterial and Viral Proteins that Manipulate the Immune System

1993 • 236 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

Role of IKK1 and IKK2 in Lipopolysaccharide Signaling in Human Monocytic Cells

1998 • 188 citations

Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50.

1998 • 187 citations

Modulation of neutrophil apoptosis by granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor during the course of acute respiratory distress syndrome

2000 • 180 citations

Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations.

1990 • 174 citations

Noninvasive intracellular delivery of functional peptides and proteins

1999 • 147 citations

A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion.

1994 • 135 citations

Peripheral Blood Leukocyte Kinetics Following In Vivo Lipopolysaccharide (LPS) Administration to Normal Human Subjects

1989 • 121 citations

Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs.

1996 • 104 citations

The adult respiratory distress syndrome: Cell populations and soluble mediators in the air spaces of patients at high risk

1988 • 102 citations

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

1989 • 98 citations

Proteolytic Processing of NF- κB/I κB in Human Monocytes

1995 • 88 citations

Lipopolysaccharide-Induced Cytokine Cascade and Lethality in LTα/TNFα-Deficient Mice

1997 • 79 citations

MyD genes in negative growth control

1998 • 77 citations

Peptide-directed Suppression of a Pro-inflammatory Cytokine Response

2000 • 60 citations

A<scp>d</scp>-Amino Acid Peptide Inhibitor of NF-κB Nuclear Localization Is Efficacious in Models of Inflammatory Disease

2000 • 57 citations

Mechanisms of cellular injury: potential sources of oxygen free radicals in ischemia/reperfusion.

1989 • 49 citations

Cellular import of functional peptides to block intracellular signaling

1997 • 45 citations

IκB Kinase Complex Is an Intracellular Target for Endotoxic Lipopolysaccharide in Human Monocytic Cells

1999 • 44 citations

Ischemia-reperfusion lung injury: contribution of ischemia, neutrophils, and hydrostatic pressure

1997 • 43 citations

Nuclear Factor of Activated T Cells Transcription Factor Nfatp Controls Superantigen-Induced Lethal Shock

2000 • 42 citations

Interferon-gamma receptor deficiency: relationship between genotype, environment, and phenotype (Review).

1998 • 28 citations