DNA vaccines: an active immunization strategy for prostate cancer

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Prostate-specific membrane antigen expression in normal and malignant human tissues.

1997 • 1,454 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine

1998 • 844 citations

Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy

1996 • 613 citations

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

1998 • 569 citations

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

2002 • 491 citations

Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer.

1999 • 468 citations

Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells.

1996 • 380 citations

DNA Vaccination: Transfection and Activation of Dendritic Cells as Key Events for Immunity

1999 • 367 citations

Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase.

1996 • 360 citations

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

2000 • 355 citations

Antigen Presentation by Dendritic Cells after Immunization with DNA Encoding a Major Histocompatibility Complex Class II–restricted Viral Epitope

1997 • 326 citations

Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptidesin vivo

1996 • 308 citations

Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing.

1992 • 265 citations

Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man

1999 • 253 citations

Evaluation of phase I/II clinical trials in prostate cancer with dendritic cells and PSMA peptides

1998 • 246 citations

Coupling and Uncoupling of Tumor Immunity and Autoimmunity

1999 • 245 citations

Infusion of dendritic cells pulsed with HLA-A2-specific prostate-specific membrane antigen peptides: A phase II prostate cancer vaccine trial involving patients with hormone-refractory metastatic disease

1999 • 242 citations

Tumor immunity and autoimmunity induced by immunization with homologous DNA.

1998 • 233 citations

Induction of Polyclonal Prostate Cancer-Specific CTL Using Dendritic Cells Transfected with Amplified Tumor RNA

2001 • 198 citations

Phase II prostate cancer vaccine trial: Report of a study involving 37 patients with disease recurrence following primary treatment

1999 • 191 citations

Naked DNA and Adenoviral Immunizations for Immunotherapy of Prostate Cancer: A Phase I/II Clinical Trial

2000 • 185 citations

Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers.

1998 • 184 citations

Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70

2000 • 176 citations

The Nagging Question of the Function ofN-Acetylaspartylglutamate

1997 • 173 citations

Vaccination of Seronegative Volunteers with a Human Immunodeficiency Virus Type 1env/revDNA Vaccine Induces Antigen‐Specific Proliferation and Lymphocyte Production of β‐Chemokines

2000 • 157 citations

Follow-up evaluation of a phase II prostate cancer vaccine trial

1999 • 147 citations

Heat shock protein-peptide complexes in cancer immunotherapy

1994 • 140 citations

Anti-Tyrosinase-Related Protein-2 Immune Response in Vitiligo Patients and Melanoma Patients Receiving Active-Specific Immunotherapy

1998 • 134 citations

Purification of Heat Shock Protein–Peptide Complexes for Use in Vaccination against Cancers and Intracellular Pathogens

1997 • 107 citations

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

1998 • 106 citations

Immunization with DNA coding for gp100 results in CD4+ T-cell independent antitumor immunity

2000 • 105 citations

Recognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen.

2002 • 96 citations

Active immunotherapy with allogeneic tumor cell vaccines: present status.

1998 • 89 citations

HLA-Independent Heterogeneity of CD8+ T Cell Responses to MAGE-3, Melan-A/MART-1, gp100, Tyrosinase, MC1R, and TRP-2 in Vaccine-Treated Melanoma Patients

1998 • 86 citations

Heat shock protein–peptide complexes as immunotherapy for human cancer

1998 • 84 citations

Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies

2000 • 78 citations

Immunization with haptenized, autologous tumor cells induces inflammation of human melanoma metastases.

1991 • 76 citations

Allogeneic whole‐cell vaccine: a phase I/II study in men with hormone‐refractory prostate cancer

2002 • 71 citations

Antibody Responses to Melanoma/Melanocyte Autoantigens in Melanoma Patients

1998 • 62 citations

Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects.

1999 • 62 citations

Heat shock protein-based cancer vaccines and related thoughts on immunogenicity of human tumors

1995 • 52 citations

Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: Isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens

2000 • 49 citations

Serological responses of melanoma patients to vaccines derived from allogeneic cultured melanoma cells

1983 • 44 citations

Intradermal injection of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with metastatic melanoma recruits dendritic cells.

1999 • 42 citations

Active specific immunotherapy in malignant melanoma

1989 • 41 citations

Vaccine therapy for patients with melanoma.

1999 • 40 citations

Identification of immunogenic human melanoma antigens in a polyvalent melanoma vaccine.

1992 • 37 citations

Immunogenicity and Clinical Activity of a Polyvalent Melanoma Antigen Vaccine Prepared from Shed Antigensa

1993 • 36 citations

Peptide and carbohydrate vaccines in relapsed prostate cancer: immunogenicity of synthetic vaccines in man--clinical trials at Memorial Sloan-Kettering Cancer Center.

1999 • 35 citations

Development of dendritic-cell based prostate cancer vaccine

2000 • 32 citations

Prostate-Specific Membrane Antigen: Much More Than a Prostate Cancer Marker.

1999 • 25 citations

VACCINE THERAPY FOR PROSTATE CANCER

1999 • 21 citations

Immunotherapy for Malignant Melanoma with a Tumor Cell Vaccine

1992 • 12 citations

Active specific immunization in malignant melanoma

1975 • 8 citations

Deleted Work

1955 • 0 citations