Antibody Responses to Melanoma/Melanocyte Autoantigens in Melanoma Patients

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.

1994 • 584 citations

A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.

1992 • 552 citations

Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside.

1994 • 522 citations

Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis.

1994 • 464 citations

Tyrosinase and related proteins in mammalian pigmentation

1996 • 439 citations

Prolongation of Survival in Metastatic Melanoma After Active Specific Immunotherapy With a New Polyvalent Melanoma Vaccine

1992 • 410 citations

Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.

1995 • 338 citations

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes.

1995 • 282 citations

Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes

1996 • 272 citations

A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.

1988 • 247 citations

Antibodies to normal human melanocytes in vitiligo.

1983 • 221 citations

The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.

1990 • 203 citations

The role of tyrosinase in autoimmune vitiligo

1994 • 198 citations

Box 1. Autoantibodies that penetrate cells

1996 • 175 citations

Molecular characterization of the melanocyte lineage-specific antigen gp100.

1994 • 169 citations

Melanoma-associated antigens as messenger RNA detection markers for melanoma.

1997 • 166 citations

A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.

1991 • 164 citations

Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity

1996 • 163 citations

Antigen-specific tumor vaccines. Development and characterization of recombinant adenoviruses encoding MART1 or gp100 for cancer therapy.

1996 • 161 citations

Prolonged Survival for Melanoma Patients With Elevated IgM Antibody to Oncofetal Antigen<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 126 citations

Identification of Pigment Cell Antigens Defined by Vitiligo Antibodies

1992 • 114 citations

Pigmentation Genes: the Tyrosinase Gene Family and the pmel 17 Gene Family

1993 • 105 citations

New treatment options for patients with melanoma: review of melanoma-derived T-cell epitope-based peptide vaccines

1996 • 105 citations

Immunobiology of Human Melanoma Antigens MART-1 and gp100 and their Use for Immuno-Gene Therapy

1997 • 104 citations

A pigmentation‐associated, differentiation antigen of human melanoma defined by a precipitating antibody in human serum

1983 • 95 citations

Immunoprecipitation of melanogenic enzyme autoantigens with vitiligo sera: evidence for cross-reactive autoantibodies to tyrosinase and tyrosinase-related protein-2 (TRP-2)

1997 • 95 citations

Relationship between immune response to melanoma vaccine immunization and clinical outcome in stage II malignant melanoma

1992 • 89 citations

A melanosomal membrane protein is a cell surface target for melanoma therapy.

1996 • 83 citations

Melanoma patients immunized with melanoma cell vaccine induce antibody responses to recombinant MAGE-1 antigen.

1995 • 78 citations

Kinetics of the immune response and regression of metastatic lesions following development of humoral anti-high molecular weight-melanoma associated antigen immunity in three patients with advanced malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23.

1994 • 78 citations

Autoantibodies to tyrosinase

1997 • 66 citations

Molecular characterization of a human tyrosinase‐related‐protein‐2 cDNA

1994 • 62 citations

Peptide‐specific ctl in tumor‐infiltrating lymphocytes from metastatic melanomas expressing mart‐1/melan‐a, gp100 and tyrosinase genes: A study in an unselected group of hla‐a2.1‐positive patients

1995 • 59 citations

Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression.

1995 • 40 citations

Detection of β-human chorionic gonadotropin mRNA as a marker for cutaneous malignant melanoma

1996 • 39 citations

Anti-tyrosinase antibodies in malignant melanoma

1996 • 36 citations

Induction of antibody response to human tumor antigens by gene therapy using a fusigenic viral liposome vaccine

1997 • 35 citations

Melanoma and vitiligo: immunology's Grecian urn

1996 • 25 citations

Antigen-specific CD8+ T cells switch the immune response induced by antigen from an IgG to a cell-mediated mode.

1992 • 17 citations

Anti-tyrosinase antibodies participate in the immune response to vaccination with anti-idiotypic antibodies mimicking the high-molecular-weight melanoma-associated antigen

1995 • 13 citations