Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis

Angiogenic Factors

1987 • 3,702 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

Regulators of Angiogenesis

1991 • 959 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Human Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial Cultivation

1983 • 801 citations

Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

1993 • 777 citations

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1994 • 743 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone

1983 • 622 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment

1985 • 492 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene

1990 • 452 citations

Mast cell heparin stimulates migration of capillary endothelial cells in vitro.

1980 • 445 citations

Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a

1989 • 444 citations

Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.

1984 • 418 citations

Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells

1987 • 387 citations

Amiloride selectively inhibits the urokinase‐type plasminogen activator

1987 • 378 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration.

1986 • 354 citations

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

1988 • 354 citations

Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis

1993 • 338 citations

Inhibition of Cell Motility by Interferon

1980 • 331 citations

Interaction of heparin with human basic fibroblast growth factor: Protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan

1989 • 304 citations

Interaction of endothelial cell growth factor with heparin: characterization by receptor and antibody recognition.

1985 • 301 citations

Control of Angiogenesis with Synthetic Heparin Substitutes

1989 • 292 citations

Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells.

1987 • 286 citations

Upregulation of urokinase receptor expression on migrating endothelial cells

1993 • 277 citations

Effect of fibroblast growth factor and lipoproteins on the proliferation of endothelial cells derived from bovine adrenal cortex, brain cortex, and corpus luteum capillaries

1986 • 273 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

Suramin: a novel antineoplastic agent with multiple potential mechanisms of action.

1993 • 229 citations

Cultured endothelial cell monolayers that restrict the transendothelial passage of macromolecules and electrical current

1984 • 217 citations

A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*

1986 • 214 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

Proteolytic balance and capillary morphogenesis

1990 • 203 citations

Microvascular Injury in Pathogenesis of Interferon-Induced Necrosis of Subcutaneous Tumors in Mice

1989 • 192 citations

Interaction of heparin with plasminogen activators and plasminogen: effects on the activation of plasminogen

1986 • 191 citations

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.

1991 • 178 citations

The extracellular regulation of growth factor action.

1992 • 176 citations

Treatment of childhood angiomatous diseases with recombinant interferon alfa-2a

1991 • 175 citations

Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro

1988 • 149 citations

Nature of the interaction of growth factors with suramin

1992 • 148 citations

Mechanism of action of angiostatic steroids: Suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis

1993 • 144 citations

A highly potent antiangiogenic activity of retinoids

1989 • 143 citations

Inhibition of tumor growth, vascularization, and collagenolysis in the rabbit cornea by medroxyprogesterone.

1981 • 136 citations

Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.

1985 • 123 citations

Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes.

1982 • 123 citations

Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors

1987 • 121 citations

Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity

1992 • 118 citations

Mechanism of retinoid‐induced activation of latent transforming growth factor‐β in bovine endothelial cells

1993 • 118 citations

Suramin: prototype of a new generation of antitumor compounds.

1990 • 101 citations

Differential effects of interferon gamma and alpha on in vitro model of angiogenesis

1991 • 94 citations

Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth.

1993 • 91 citations

Inhibition of angiogenesis by suramin.

1992 • 89 citations

Stimulation of Tissue-Type Plasminogen Activator Synthesis by Retinoids in Cultured Human Endothelial Cells and Rat Tissues In Vivo

1991 • 89 citations

The addition of endothelial cell growth factor and heparin to human umbilical vein endothelial cell cultures decreases plasminogen activator inhibitor-1 expression.

1988 • 87 citations

The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events

1985 • 84 citations

Inhibition of in vitro angiogenesis by lymphotoxin and interferon-γ

1988 • 81 citations

Effects of rIFN Alpha, Beta, and Gamma on the Morphology, Proliferation, and Cell Surface Antigen Expression of Human Dermal Microvascular Endothelial Cells In Vitro

1990 • 75 citations

The Effects of Basic Fibroblast Growth Factor and suramin on Cell Motility and Growth of Rat Prostate Cancer Cells

1991 • 70 citations

Angiogenesis

1988 • 66 citations

Bovine urokinase-type plasminogen activator and its receptor: Cloning and induction by retinoic acid

1993 • 63 citations

Effects of Exogenous Heparin on the Vasculogenesis of the Chorioallantoic Membrane

1987 • 63 citations

Tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon

1992 • 62 citations

Epidermal growth factor receptor expression and suramin cytotoxicity in vitro

1990 • 55 citations

Medroxyprogesterone acetate, an anti‐cancer and anti‐angiogenic steroid, inhibits the plasminogen activator in bovine endothelial cells

1989 • 53 citations

Heparin-steroid conjugates: new angiogenesis inhibitors with antitumor activity in mice.

1993 • 52 citations

Modulation of endothelial cell shape and growth by retinoids

1991 • 51 citations

Hyperthermia stimulates plasminogen activator inhibitor type 1 expression in human umbilical vein endothelial cells in vitro.

1991 • 51 citations

Heparin enhances angiogenesis by a systemic mode of action.

1992 • 50 citations

Antiproliferative effects of suramin on androgen responsive tumour cells

1990 • 50 citations

Inhibition of Angiogenesis with Combination Treatments of Angiostatic Steroids and Suramin

1991 • 50 citations

Tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon

1992 • 46 citations

Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin.

1993 • 42 citations

Effect of retinoic acid on the synthesis of tissue‐type plasminogen activator and plasminogen activator inhibitor‐1 in human endothelial cells

1991 • 41 citations

Modulation of endothelial cells growth induced by heparin

1986 • 41 citations

Reduction in pO2 decreases the fibrinolytic potential of cultured bovine endothelial cells derived from pulmonary arteries and lung microvasculature

1988 • 40 citations

Inhibition of human endothelial cell proliferation by heparin and steroids

1988 • 38 citations

Heparin potentiation of 3T3‐adipocyte stimulated angiogenesis: Mechanisms of action on endothelial cells

1986 • 37 citations

Plasminogen activator inhibitor-1 is induced in microvascular endothelial cells by a chondrocyte-derived transforming growth factor-beta

1991 • 30 citations

Stimulation of tissue plasminogen activator production by retinoic acid: synergistic effect on protein kinase C-mediated activation

1992 • 28 citations

γ-Interferon counteracts interleukin-1α stimulated expression of urokinase-type plasminogen activator in human endothelial cells in vitro

1992 • 27 citations

Sulfated polysaccharides modulate effects of acidic and basic fibroblast growth factors on repair of injured confluent human vascular endothelium.

1989 • 27 citations

Stimulation of tissue plasminogen activator production by retinoic acid: synergistic effect on protein kinase C-mediated activation

1992 • 27 citations

Vascularization Induced in the Cheek Pouch of the Syrian Hamster by Tumor and Nontumor Substances2

1976 • 23 citations

Antiangiogenic Effect of Heparin and Other Sulphated Glycosaminoglyycans in the Chick Embryo Chorioallantoic Membrane

1991 • 19 citations

Growth stimulation of bovine endothelial cells by vitamin A

1981 • 18 citations

Synergism of vitamins A and C on fibrinolysis

1985 • 17 citations

Evaluation of the effect of suramin on neural cell growth and N-CAM expression.

1990 • 15 citations

Centrosome reorientation in regenerating endothelial monolayers requires bFGF

1993 • 12 citations

SYNERGISM OF RETINOIDS AND _L-ASCORBIC ACID IN PRODUCING PLASMINOGEN ACTIVATOR IN ENDOTHELIAL CELLS

1986 • 11 citations

Immunoradiometric quantitation of tissue plasminogen activator-related antigen in human plasma: crypticity phenomenon and relationship to plasma fibrinolysis

1987 • 10 citations

Antitumor Action of Retinoids: Inhibition of Tumor Cell Line-Induced Angiogenesis and Prevention of Tumors in Mice

1992 • 9 citations