Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

The Fas Death Factor

1995 • 4,070 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

The Pathogenesis of Insulin-Dependent Diabetes Mellitus

1994 • 1,077 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

1994 • 363 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

1994 • 331 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Superantigen-Dependent, Cell-Mediated Cytotoxicity Inhibited by MHC Class I Receptors on T Lymphocytes

1995 • 316 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

1989 • 246 citations

Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production

1995 • 221 citations

Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium.

1993 • 218 citations

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

1994 • 188 citations

The Yin and Yang of T Cell Costimulation

1995 • 180 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

1992 • 151 citations

Altered Cytokine Activity in Adjuvant Inhibition of Autoimmune Diabetes

1993 • 151 citations

Analysis of the roles of CD4⁺ and CD8⁺ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice

1992 • 145 citations

In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice.

1995 • 141 citations

Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice

1994 • 138 citations

Genetic and pathogenic basis of autoimmune diabetes in NOD mice

1994 • 136 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.

1993 • 127 citations

Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice.

1994 • 121 citations

The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.

1994 • 104 citations

Islet-Specific T-Cell Clones From the NOD Mouse Respond to β-Granule Antigen

1994 • 99 citations

Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAb

1994 • 71 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

Expression of the Co-stimulator Molecule B7–1 in Pancreatic β-Cells Accelerates Diabetes in the NOD Mouse

1995 • 67 citations

CD4+ beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice.

1995 • 57 citations

On the various manifestations of spontaneous autoimmune diabetes in rodent models

1994 • 57 citations

Isolation of Nonobese Diabetic Mouse T-Cells That Recognize Novel Autoantigens Involved in the Early Events of Diabetes

1994 • 46 citations

Down‐modulation of CD4⁺ T helper type 2 and type 0 cells by T helper type 1 cells via Fas/Fasligand interaction

1995 • 41 citations

Prevention of autoimmune type I diabetes by CD4+ suppressor T cells in superantigen-treated non-obese diabetic mice.

1993 • 39 citations

Regulation of autoimmune response

1994 • 38 citations

T-cell autoimmunity in type 1 diabetes mellitus

1993 • 24 citations

Transgenic mice expressing constitutive levels of IL-2 in islet β cells develop diabetes

1994 • 21 citations

Vaccination or tolerance to prevent diabetes

1992 • 20 citations

An anergic, islet-infiltrating T-cell clone that suppresses murine diabetes secretes a factor that blocks interleukin 2/interleukin 4-dependent proliferation.

1992 • 19 citations

Absence of T cell tolerance to pancreatic islet cells.

1992 • 17 citations

Intercellular adhesion molecule-1 (ICAM-1) expression in the islets of the non-obese diabetic and low-dose streptozocin-treated mouse

1994 • 12 citations