T-cell autoimmunity in type 1 diabetes mellitus

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

The Murine Autoimmune Diabetes Model: NOD and Related Strains

1992 • 498 citations

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.

1990 • 454 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

1993 • 431 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

The cognitive paradigm and the immunological homunculus

1992 • 375 citations

A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus

1994 • 336 citations

Does Nitric Oxide Mediate Autoimmune Destruction of β-Cells?: Possible Therapeutic Interventions in IDDM

1992 • 299 citations

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.

1992 • 290 citations

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1992 • 275 citations

γ‐Aminobutyric Acid Outside the Mammalian Brain

1990 • 256 citations

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

1990 • 245 citations

Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

1992 • 243 citations

Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study.

1985 • 237 citations

1,25-Dihydroxyvitamin D3 Prevents Insulitis in NOD Mice

1992 • 230 citations

Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

1991 • 212 citations

The cognitive principle challenges clonal selection

1992 • 212 citations

Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice.

1993 • 176 citations

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.

1993 • 172 citations

Autoimmunity to Chaperonins in the Pathogenesis of Arthritis and Diabetes

1991 • 172 citations

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

1991 • 171 citations

Insulin in the brain: a hormonal regulator of energy balance

1992 • 167 citations

Analysis of the roles of CD4⁺ and CD8⁺ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice

1992 • 145 citations

Prevention of Autoimmune Diabetes in the BB Rat by Intrathymic Islet Transplantation at Birth

1992 • 141 citations

Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis

1993 • 134 citations

Prevention of Autoimmune Diabetes With Nonactivating Anti-CD3 Monoclonal Antibody

1992 • 132 citations

Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase

1993 • 132 citations

Prevention of Insulitis and Diabetes Onset by Treatment With Complete Freund's Adjuvant in NOD Mice

1991 • 126 citations

Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.

1993 • 125 citations

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1993 • 125 citations

Intrathymic Islet Cell Transplantation Reduces β-Cell Autoimmunity and Prevents Diabetes in NOD/Lt Mice

1992 • 118 citations

Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes.

1993 • 113 citations

T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes

1991 • 110 citations

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent.

1991 • 108 citations

The use of a non‐depleting anti‐CD4 monoclonal antibody to re‐establish tolerance to β cells in NOD mice

1992 • 104 citations

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited

1992 • 97 citations

Variability in T cell receptor V beta gene usage in human peripheral blood lymphocytes. Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients.

1992 • 95 citations

Suppression of development of diabetes in NOD mice by lactate dehydrogenase virus infection

1992 • 87 citations

Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM

1992 • 81 citations

1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice

1992 • 74 citations

The genetics and epidemiology of diabetes in NOD mice

1990 • 71 citations

CD8 T Cells Are Not Required for Islet Destruction Induced by a CD4+ Islet-Specific T-Cell Clone

1992 • 69 citations

Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice

1991 • 67 citations

Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats

1991 • 67 citations

Studies on Autoimmunity for T-Cell-Mediated β-Cell Destruction: Distinct Difference in β-Cell Destruction Between CD4+ and CD8+ T-Cell Clones Derived From Lymphocytes Infiltrating the Islets of NOD Mice

1992 • 60 citations

A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant.

1992 • 57 citations

Insulin prevents adoptive cell transfer of diabetes in the autoimmune non-obese diabetic mouse

1991 • 57 citations

Exclusive Expression of MHC Class II Proteins on CD45+ Cells in Pancreatic Islets of NOD Mice

1991 • 56 citations

Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.

1992 • 56 citations

Progression to Diabetes in Nonobese Diabetic (NOD) Mice with Transgenic T Cell Receptors

1993 • 53 citations

Syngeneic t cell transfer of diabetes into nod newborn mice: in situ studies of the autoimmune steps leading to insulin‐producing cell destruction

1989 • 52 citations

Induction of tolerance to autoimmune diabetes with islet antigens.

1992 • 48 citations

Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice

1992 • 41 citations

Transcription Factor jun-B is Target of Autoreactive T-Cells in IDDM

1993 • 40 citations

Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody

1992 • 36 citations

Secretory granule autoantigen in insulin-dependent diabetes mellitus is related to 62 kDa heat-shock protein (hsp60)

1992 • 35 citations

Prevention of Adoptive Transfer in BB Rats by Prophylactic Insulin Treatment

1992 • 33 citations

CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone

1992 • 32 citations

Germ-line polymorphism of TCR genes and disease susceptibility — fact or hypothesis?

1992 • 31 citations

Association of susceptibility to multiple sclerosis with TCR genes

1992 • 31 citations

β-Cell Antigen–Specific Lysis of Macrophages by CD4 T-Cell Clones From Newly Diagnosed IDDM Patient: A Putative Mechanism of T-Cell–Mediated Autoimmune Islet Cell Destruction

1992 • 29 citations

On the Honey Disease: A Dialogue With Socrates [ΠEPI TOY MEΛITOΣ ΠAΘOYΣ ΔIAΛOΓOΣ ΣΩKPATH –]

1993 • 29 citations

Studies on autoimmunity for T-cell-mediated beta-cell destruction. Distinct difference in beta-cell destruction between CD4+ and CD8+ T-cell clones derived from lymphocytes infiltrating the islets of NOD mice

1992 • 27 citations

Prevention of Autoimmune Diabetes with Lymphotoxin in NOD Mice

1993 • 27 citations

Granulocyte-Colony Stimulating Factor Improves an Impaired Bactericidal Function in Neutrophils From STZ-Induced Diabetic Rats

1993 • 23 citations

The Temporal Association Between γδ T Cells and the Natural History of Insulin-Dependent Diabetes

1993 • 21 citations

Exclusive expression of MHC class II proteins on CD45+ cells in pancreatic islets of NOD mice

1991 • 20 citations

Molecular mechanisms underlying diabetes and other autoimmune diseases

1993 • 19 citations

Transcription factor jun-B is target of autoreactive T-cells in IDDM

1993 • 19 citations

An anergic, islet-infiltrating T-cell clone that suppresses murine diabetes secretes a factor that blocks interleukin 2/interleukin 4-dependent proliferation.

1992 • 19 citations

A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: Co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes

1992 • 18 citations

Studies on autoimmunity for initiation of Beta-cell destruction VIII. Pancreatic Beta-cell dependent autoantibody to a 38 kilodalton protein precedes the clinical onset of diabetes in BB rats

1991 • 18 citations

Absence of T cell tolerance to pancreatic islet cells.

1992 • 17 citations

The 12th International Immunology and Diabetes Workshop: Orlando, Florida

1993 • 16 citations

Quantitative analyses comparing all major spleen cell phenotypes in BB and normal rats: Autoimmune imbalance and double negative T cells associated with resistant, prone and diabetic animals

1992 • 14 citations

Prevention of autoimmune diabetes with lymphotoxin in NOD mice

1993 • 13 citations

Prevention of adoptive transfer in BB rats by prophylactic insulin treatment

1992 • 10 citations

Beta-cell antigen-specific lysis of macrophages by CD4 T-cell clones from newly diagnosed IDDM patient. A putative mechanism of T-cell-mediated autoimmune islet cell destruction

1992 • 9 citations

Genetic analysis of a complex, multifactorial disease, autoimmune type 1 (insulin-dependent) diabetes

1991 • 8 citations

Transgenes in autoimmunity

1992 • 8 citations

The 12th International Immunology and Diabetes Workshop. Orlando, Florida

1993 • 6 citations

Mechanisms and significance of HLA type I diabetes association

1991 • 2 citations