Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases

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Green Tea Consumption and Mortality Due to Cardiovascular Disease, Cancer, and All Causes in Japan

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Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

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Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

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Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

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Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

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Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease

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Green tea polyphenol (–)‐epigallocatechin‐3‐gallate prevents N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration

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HIF1 and oxygen sensing in the brain

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Epigallocatechin Gallate, a Constituent of Green Tea, Represses Hepatic Glucose Production

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Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models

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The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity

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Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project

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Involvement of Protein Kinase C Activation and Cell Survival/ Cell Cycle Genes in Green Tea Polyphenol (−)-Epigallocatechin 3-Gallate Neuroprotective Action

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A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

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Parkinson's Disease Risks Associated with Cigarette Smoking, Alcohol Consumption, and Caffeine Intake

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Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐)‐epigallocatechin‐3‐gallate

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Tea Enhances Insulin Activity

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Brain iron pathways and their relevance to Parkinson's disease

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Multifunctional Activities of Green Tea Catechins in Neuroprotection

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The green tea polyphenol (−)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons

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Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21^waf1/cip1, and Erythropoietin

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Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-κB Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis

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Antioxidant compounds have potent anti‐fibrillogenic and fibril‐destabilizing effects for α‐synuclein fibrils in vitro

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The Iron Chelator Desferrioxamine (Desferal) Retards 6‐Hydroxydopamine‐Induced Degeneration of Nigrostriatal Dopamine Neurons

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Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures11Abbreviations: BT, Black Tea; EMSA, Electromobility Shift Assay; EGCG, (-)-Epigallocatechin-3-gallate; GT, Green Tea; NB SH-SY5Y cells, Human neuroblastoma SH-SY5Y cells; 6-OHDA, 6-hydroxydopamine; IL, Interleukin; LDH, Lactate Dehydrogenase; MPTP, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB, nuclear factor-κB; OS, Oxidative Stress; PD, …

2002 • 291 citations

Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

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Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Aβ42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease

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Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice.

1994 • 283 citations

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

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Coffee and tea consumption and the risk of Parkinson's disease

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Effects of pH and Metal Ions on Antioxidative Activities of Catechins

2001 • 270 citations

Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases

2004 • 268 citations

Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils

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Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease

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Neuroprotective Strategies in Parkinson???s Disease

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Age-Related Amyloid β Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid β Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss

2000 • 227 citations

Long-Term Administration of Green Tea Catechins Improves Spatial Cognition Learning Ability in Rats

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Hypoxic regulation of the 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase gene family (PFKFB‐1–4) expression in vivo

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α-synuclein implicated in Parkinson’s disease catalyses the formation of hydrogen peroxide in vitro

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Protective effects of tea polyphenols against oxidative damage to red blood cells

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Reduction of iron‐regulated amyloid precursor protein and β‐amyloid peptide by (–)‐epigallocatechin‐3‐gallate in cell cultures: implications for iron chelation in Alzheimer's disease

2006 • 182 citations

Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression

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(‐)Epicatechin stimulates ERK‐dependent cyclic AMP response element activity and up‐regulates GluR2 in cortical neurons

2007 • 172 citations

Iron and α-Synuclein in the Substantia Nigra of MPTP-Treated Mice: Effect of Neuroprotective Drugs R-Apomorphine and Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate

2004 • 170 citations

Positioning Atypical Protein Kinase C Isoforms in the UV-Induced Apoptotic Signaling Cascade

1997 • 164 citations

Green Tea Polyphenols Modulate Insulin Secretion by Inhibiting Glutamate Dehydrogenase

2006 • 163 citations

Iron dysregulation in Alzheimer's disease: Multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

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Recent developments in the pathology of Parkinson’s disease

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The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice

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Green tea polyphenol (–)‐epigallocatechin‐3‐gallate induces neurorescue of long‐term serum‐deprived PC12 cells and promotes neurite outgrowth

2005 • 146 citations

Metal and Inflammatory Targets for Alzheimers Disease

2004 • 145 citations

Neuroprotective effects of (−)‐epigallocatechin gallate after hypoxia‐ischemia‐induced brain damage: novel mechanisms of action

2004 • 138 citations

Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease

2005 • 138 citations

Prevention and restoration of lactacystin‐induced nigrostriatal dopamine neuron degeneration by novel brain‐permeable iron chelators

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Green tea catechins prevent cognitive deficits caused by Aβ1–40 in rats

2008 • 132 citations

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

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cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells

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Estrogen activates protein kinase C in neurons: role in neuroprotection

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PKCε increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice

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Genetic regulation of cell function in response to iron overload or chelation

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Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains.

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Epsilon Protein Kinase C Mediated Ischemic Tolerance Requires Activation of the Extracellular Regulated Kinase Pathway in the Organotypic Hippocampal Slice

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Evidence that the Early Loss of Membrane Protein Kinase C Is a Necessary Step in the Excitatory Amino Acid‐Induced Death of Primary Cortical Neurons

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Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species.

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Hypoxia-Inducible Factor-1 Activation by (−)-Epicatechin Gallate: Potential Adverse Effects of Cancer Chemoprevention with High-Dose Green Tea Extracts

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Involvement of amyloid precursor protein in functional synapse formation in cultured hippocampal neurons

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A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated τ of Alzheimer’s disease

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Pharmacological demonstration of the differential involvement of protein kinase C isoforms in short- and long-term memory formation and retrieval of one-trial avoidance in rats

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Green tea polyphenol (–)‐epigallocatechin‐3‐gallate promotes the rapid protein kinase C‐ and proteasome‐mediated degradation of Bad: implications for neuroprotection

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Epigallocatechin gallate inhibits HIF-1α degradation in prostate cancer cells

2005 • 75 citations

A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant–iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate

2007 • 73 citations

Green tea polyphenol (−)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal

2003 • 70 citations

In vivo detection of iron and neuromelanin by transcranial sonography – a new approach for early detection of substantia nigra damage

2006 • 70 citations

Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases

2006 • 66 citations

Catechin and epicatechin from Smilacis chinae rhizome protect cultured rat cortical neurons against amyloid β protein (25–35)-induced neurotoxicity through inhibition of cytosolic calcium elevation

2006 • 66 citations

Green tea catechins as brain-permeable, non toxic iron chelators to “iron out iron” from the brain

2006 • 64 citations

Evaluation of new iron chelators and their therapeutic potential

2002 • 61 citations

The application of proteomics for studying the neurorescue activity of the polyphenol (−)-epigallocatechin-3-gallate

2008 • 31 citations

Phospholipase C, protein kinase C, Ca²⁺/calmodulin‐dependent protein kinase II, and redox state are involved in epigallocatechin gallate‐induced phospholipase D activation in human astroglioma cells

2004 • 26 citations

Lysosomal deposition of Aβ in cultures of brain vascular smooth muscle cells is enhanced by iron

2004 • 25 citations

The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL

2004 • 23 citations