Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart

1996 • 531 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

1998 • 382 citations

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

1997 • 374 citations

Expression of bcl-2 Protein, an Inhibitor of Apoptosis, and Bax, an Accelerator of Apoptosis, in Ventricular Myocytes of Human Hearts With Myocardial Infarction

1996 • 367 citations

The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression

1998 • 238 citations

Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol

1998 • 236 citations

Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.

1996 • 233 citations

The bcl-2 Gene Product Prevents Programmed Cell Death of Ventricular Myocytes

1997 • 225 citations

Cellular Stresses Differentially Activate c-Jun N-terminal Protein Kinases and Extracellular Signal-regulated Protein Kinases in Cultured Ventricular Myocytes

1995 • 212 citations

Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes

1998 • 182 citations

Stimulation of c-Jun Kinase and Mitogen-Activated Protein Kinase by Ischemia and Reperfusion in the Perfused Rat Heart

1996 • 180 citations

Expression of Polyglutamine-expanded Huntingtin Activates the SEK1-JNK Pathway and Induces Apoptosis in a Hippocampal Neuronal Cell Line

1998 • 128 citations

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

1997 • 120 citations

Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH₂-Terminal Kinase-Specific Kinase

1997 • 108 citations

Regulators of apoptosis in the heart: a matter of life and death.

1998 • 12 citations