The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

2001 • 1,385 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Cytokines and Cytokine Receptors in Advanced Heart Failure

2001 • 985 citations

THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS

1997 • 876 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy

2001 • 696 citations

Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.

1992 • 611 citations

Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart

1996 • 531 citations

Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

1994 • 525 citations

Apoptosis and Heart Failure

2000 • 512 citations

“Stress-Responsive” Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium

1998 • 510 citations

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction

2000 • 423 citations

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

1998 • 335 citations

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

1998 • 322 citations

A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression

1997 • 320 citations

Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-β ₂ –Knockout Mice

2001 • 302 citations

Hemodynamic Regulation of Tumor Necrosis Factor-α Gene and Protein Expression in Adult Feline Myocardium

1997 • 284 citations

Mekk3 is essential for early embryonic cardiovascular development

2000 • 243 citations

MEK kinase 1 gene disruption alters cell migration and c-Jun NH ₂ -terminal kinase regulation but does not cause a measurable defect in NF-κB activation

2000 • 240 citations

Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy

1998 • 234 citations

The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy

1997 • 231 citations

Mechanical Stretch and Angiotensin II Differentially Upregulate the Renin-Angiotensin System in Cardiac Myocytes In Vitro

1999 • 204 citations

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.

1998 • 198 citations

Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes.

1994 • 195 citations

Cyclosporine Attenuates Pressure-Overload Hypertrophy in Mice While Enhancing Susceptibility to Decompensation and Heart Failure

1999 • 180 citations

Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases

1999 • 179 citations

Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice

1999 • 168 citations

MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

1997 • 152 citations

Cardiac Overexpression of a G _q Inhibitor Blocks Induction of Extracellular Signal–Regulated Kinase and c-Jun NH ₂ -Terminal Kinase Activity in In Vivo Pressure Overload

2001 • 136 citations

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

1999 • 134 citations

MEK Kinase 1 (MEKK1) Transduces c-Jun NH2-terminal Kinase Activation in Response to Changes in the Microtubule Cytoskeleton

1999 • 125 citations

Cytoprotection by Jun Kinase During Nitric Oxide–Induced Cardiac Myocyte Apoptosis

2001 • 123 citations

Inhibition of C-Jun N-Terminal Kinase 1, but Not c-Jun N-Terminal Kinase 2, Suppresses Apoptosis Induced by Ischemia/Reoxygenation in Rat Cardiac Myocytes

2001 • 122 citations

β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse

1999 • 120 citations

Overexpression of Tumor Necrosis Factor- α Activates Both Anti- and Pro-Apoptotic Pathways in the Myocardium

2001 • 112 citations

MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq

2002 • 100 citations

Proinflammatory consequences of transgenic Fas ligand expression in the heart

2000 • 88 citations

Collaborative Roles for c-Jun N-terminal Kinase, c-Jun, Serum Response Factor, and Sp1 in Calcium-regulated Myocardial Gene Expression

1997 • 78 citations

Activation of Cardiac c-Jun NH ₂ -Terminal Kinases and p38-Mitogen–Activated Protein Kinases With Abrupt Changes in Hemodynamic Load

2001 • 61 citations

Cyclosporine Reduces Left Ventricular Mass with Chronic Aortic Banding in Mice, Which Could be due to Apoptosis and Fibrosis

2001 • 39 citations

Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro

2000 • 25 citations