Pharmacological consequences of oxidative stress in ocular tissues

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Antioxidants, Oxidative Damage and Oxygen Deprivation Stress: a Review

2002 • 3,811 citations

The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration

2000 • 1,987 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

Calcium and oxidative stress: from cell signaling to cell death

2002 • 803 citations

Antioxidant Therapy in Acute Central Nervous System Injury: Current State

2002 • 567 citations

The isoprostanes

1996 • 451 citations

Quantification of Isoprostanes as Indices of Oxidant Stress and the Risk of Atherosclerosis in Humans

2005 • 447 citations

Advanced glycation end products increase retinal vascular endothelial growth factor expression.

1998 • 413 citations

Redox regulation in the lens

2003 • 405 citations

Neuroprotection in Relation to Retinal Ischemia and Relevance to Glaucoma

1999 • 400 citations

Glutathione: A Vital Lens Antioxidant

2000 • 391 citations

Peroxynitrite Inhibits Glutamate Transporter Subtypes

1996 • 375 citations

Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury

2004 • 335 citations

The Isoprostanes: Unique Products of Arachidonic Acid Oxidation-A Review

2003 • 261 citations

Retinal Oxidative Stress Induced by High Intraocular Pressure

2004 • 256 citations

Characterization of receptors for glutamate and GABA in retinal neurons

2004 • 232 citations

Hydrogen Peroxide Causes Significant Mitochondrial DNA Damage in Human RPE Cells

1999 • 206 citations

Morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in eyes with age-related macular degeneration.

1996 • 196 citations

THE ISOPROSTANES: THEIR QUANTIFICATION AS AN INDEX OF OXIDANT STRESS STATUS IN VIVO^†

2000 • 192 citations

Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation

2002 • 183 citations

Antioxidant Enzymes in the Aging Human Retinal Pigment Epithelium

1991 • 177 citations

Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles

2004 • 174 citations

Ocular Oxidants and Antioxidant Protection

1998 • 170 citations

Effect of oxidative stress on receptors and signal transmission

1992 • 162 citations

Dependence of photoreceptor glutamate release on a dihydropyridine-sensitive calcium channel

1997 • 138 citations

Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin.

2002 • 135 citations

Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells.

1998 • 130 citations

Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2

2003 • 130 citations

Interplay between mitochondria and cellular calcium signalling

2003 • 122 citations

Nonenzymatic Free Radical-catalyzed Generation of Thromboxane-like Compounds (Isothromboxanes) in Vivo

1996 • 117 citations

Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress

2004 • 103 citations

Peroxynitrite and oxidative damage in experimental autoimmune uveitis.

1997 • 103 citations

Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells

2001 • 97 citations

Hydrogen peroxide stimulates rat colonic prostaglandin production and alters electrolyte transport.

1990 • 96 citations

An Evaluation of the Role of Calcium in Cell Injury

1995 • 95 citations

The retina: oxidative stress and diabetes

2003 • 94 citations

Neuroprotection in glaucoma.

2003 • 93 citations

Role of oxidative stress as physiopathologic factor in the preterm infant.

2004 • 88 citations

Free Radicals and Aging of Anterior Segment Tissues of the Eye: A Hypothesis

1995 • 85 citations

Effect of lipid peroxidation inhibition on retinal ganglion cell death.

1996 • 78 citations

Lipid peroxidation in open‐angle glaucoma

1989 • 76 citations

Cataract formation and prevention

2004 • 73 citations

Abnormalities of retinal metabolism in diabetes or galactosemia II. Comparison of γ-glutamyl transpeptidase in retina and cerebral cortex, and effects of antioxidant therapy

1994 • 72 citations

Hemodynamic Effects of Isoprostanes (8-Iso-Prostaglandin F2α and E2) in Isolated Guinea Pig Hearts

1997 • 71 citations

Hydrogen peroxide modulates whole cell Ca2+ currents through L-type channels in cultured rat dentate granule cells

2004 • 69 citations

Ocular pathology in mitochondrial superoxide dismutase (Sod2)-deficient mice.

2001 • 67 citations

Free Radicals Enhance Basal Release of D‐[³H]Aspartate from Cerebral Cortical Synaptosomes

1994 • 58 citations

Nitric oxide and Fenton/Haber–Weiss chemistry: nitric oxide is a potent antioxidant at physiological concentrations

2003 • 55 citations

Free Radicals in Rabbit Retina Under Ocular Hyperpressure and Functional Consequences

1997 • 52 citations

Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen

2002 • 47 citations

Hydrogen Peroxide Induces a Long‐Lasting Inhibition of the Ca²⁺‐Dependent Glutamate Release in Cerebrocortical Synaptosomes Without Interfering with Cytosolic Ca²⁺

1995 • 45 citations

Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells.

1995 • 41 citations

Malondialdehyde and Antioxidant Enzyme Levels in the Aqueous Humor of Rabbits in Endotoxin-Induced Uveitis

2003 • 33 citations

Functional characterization of α-adrenoceptors mediating pupillary dilation in rats

2003 • 32 citations

Lipid Peroxidation in the Iris and Its Protection by Means of Viscoelastic Substances (Sodium Hyaluronate and Hydroxypropylmethylcellulose)

1993 • 29 citations

Do sympathetic nerves release noradrenaline in “quanta”?

2000 • 27 citations

On the Role of Adenylate Cyclase in Presynaptic Modulation of Neurotransmitter Release Mediated by Monoamine and Opioid Receptors in the Brain

1990 • 27 citations

Calcium mobilization from mitochondria in synaptic transmitter release

2003 • 26 citations

Characterization of α2-Adrenoceptor Subtypes in the Porcine Eye: Identification of α2A-Adrenoceptors in the Choroid, Ciliary Body and Iris, and α2A- and α2C-Adrenoceptors in the Retina

1996 • 25 citations

Effect of 8-iso Prostaglandin E2 on Aqueous Humor Dynamics in Monkeys

1998 • 23 citations

Metabotropic glutamate receptors in vertebrate retina.

2003 • 23 citations

Effects of intracameral hydrogen peroxide in the rabbit anterior chamber.

1988 • 21 citations

Dual Effect of Isoprostanes on the Release of [3H]D-Aspartate from Isolated Bovine Retinae: Role of Arachidonic Acid Metabolites

2005 • 19 citations

Aqueous Humor Dynamics in Monkeys after Topical 8-Iso PGE₂

2004 • 19 citations

3-amino-triazole effects on the eye of young and adult rabbits in the presence and absence of hydrogen peroxide

1987 • 18 citations

Effect of isoprostanes on sympathetic neurotransmission in the human isolated iris-ciliary body.

2000 • 16 citations

Regulation of uveal sympathetic neurotransmission by peroxides.

1997 • 15 citations

Calcium-Dependent Proteolysis in Rabbit Lens Epithelium after Oxidative Stress

1998 • 15 citations

Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes

2001 • 14 citations

Thromboxane Mimetics Enhance Adrenergic Neurotransmission in the Rabbit-Isolated Portal Vein

1989 • 14 citations

Glutamate release evoked by glutamate receptor agonists in cultured chick retina cells: Modulation by arachidonic acid

1996 • 14 citations

Striatal Dopamine Dynamics Are Altered Following an Intranigral Infusion of Iron in Adult Rats

1998 • 14 citations

Chapter 7 Real time imaging of the production and movement of nitric oxide in the retina

2001 • 13 citations

Peroxide toxicity in conditioned lens epithelial cells – evaluation of multi-defense systems

2003 • 13 citations

Hydrogen Peroxide‐Induced Broncho‐ and Vasoconstriction in the Isolated Perfused and Ventilated Guinea Pig Lung

1993 • 11 citations

Arachidonic acid metabolites and peroxide-induced inhibition of [3H]D-aspartate release from bovine isolated retinae

2004 • 11 citations

Pretreatment with H2O2Decreases the Ca2+Sensitivity of the Exocytosis of Glutamate in Cerebrocortical Synaptosomes

1996 • 10 citations

Role of Cyclic AMP in Hydrogen Peroxide-Induced Potentiation of Sympathetic Neurotransmission in the Bovine Iris

1997 • 9 citations

Mechanism of Peroxide-Induced Potentiation of Sympathetic Neurotransrnission in Bovine Irides: Role of Extracellular Calcium

1998 • 9 citations

Prejunctional alpha2-adrenoceptors and peroxide-induced potentiation of norepinephrine release from the bovine iris.

1998 • 8 citations

Thromboxane A2 augments adrenergic neurotransmission.

1990 • 7 citations

[Lipid peroxidation in the pathogenesis of primary open-angle glaucoma].

2003 • 7 citations

Effect of inhibition of cyclooxygenase on pre- and postjunctional actions of peroxides in the iris-ciliary body.

2000 • 7 citations

Role of Intracellular Calcium in Peroxide-Induced Potentiation of Norepinephrine Release from Bovine Isolated Irides

1998 • 6 citations

Role of eicosanoids in the ocular response to intracameral hydrogen peroxide.

1990 • 6 citations

Effect of hydrogen peroxide on amino acid concentrations in bovine retina and vitreous humor, ex vivo

2003 • 5 citations

Role of Catalase in Pre- and Postjunctional Responses of Mammalian Irides to Hydrogen Peroxide

2000 • 4 citations

[Glycosylation and lipid peroxidation in skin and in plasma in diabetic patients].

1997 • 3 citations

Effect of Peroxides on [³H]d-Aspartate Release from Bovine Isolated Retinae

2004 • 2 citations

Effect of EPO on isolated rat retina ERG b–wave amplitude.

2004 • 2 citations