Peroxide toxicity in conditioned lens epithelial cells – evaluation of multi-defense systems

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Free radicals in biology and medicine

1991 • 17,840 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

Irreversible reaction of 3-amino-1:2:4-triazole and related inhibitors with the protein of catalase

1960 • 485 citations

Glutathione: A Vital Lens Antioxidant

2000 • 391 citations

Oxidative Stress, Human Genetic Variation, and Disease

2001 • 304 citations

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.

1977 • 297 citations

The search for a solution to senile cataracts. Proctor lecture.

1984 • 268 citations

Free radicals in biology and medicine

1985 • 249 citations

Glutathione and its function in the lens—An overview

1990 • 246 citations

Review: Oxidative Stress and Disease

2000 • 230 citations

Superoxide dismutase of the eye Relative functions of superoxide dismutase and catalase in protecting the ocular lens from oxidative damage

1978 • 167 citations

Nuclear light scattering, disulfide formation and membrane damage in lenses of older guinea pigs treated with hyperbaric oxygen

1995 • 146 citations

Mechanisms of cataract formation in the human lens

1981 • 127 citations

A brief photochemically induced oxidative insult causes irreversible lens damage and cataract II. Mechanism of action

1995 • 112 citations

The role of glutathione metabolism in the detoxification of H2O2 in rabbit lens.

1982 • 109 citations

Hydrogen peroxide-induced DNA damage in bovine lens epithelial cells

1990 • 88 citations

DNA single strand breaks in human lens epithelial cells from patients with cataract

1993 • 86 citations

Oxidative modification of lens crystallins by H2O2 and chelated iron

1989 • 86 citations

Synthesis of α-crystallin by a cell line derived from the lens of a transgenic animal

1990 • 76 citations

A brief photochemically induced oxidative insult causes irreversible lens damage and cataract I. Transparency and epithelial cell layer

1995 • 76 citations

The relative roles of the glutathione redox cycle and catalase in the detoxification of H2O2 by cultured rabbit lens epithelial cells

1990 • 74 citations

Variation in Cellular Glutathione Peroxidase Activity in Lens Epithelial Cells, Transgenics and Knockouts Does Not Significantly Change the Response to H2O2Stress

1996 • 66 citations

Peroxide-Induced Damage in Lenses of Transgenic Mice with Deficient and Elevated Levels of Glutathione Peroxidase

1997 • 54 citations

Amizol-Induced Cataract and Inhibition of Lens Catalase in Rabbit

1973 • 52 citations

[15] 1,3-Bis(2-chloroethyl)-1-nitrosourea as Thiol-carbamoylating agent in biological Systems

1995 • 51 citations

Repair of H2O2-induced DNA damage in bovine lens epithelial cell cultures

1989 • 49 citations

Effect of H2O2on Human Lens Epithelial Cells and the Possible Mechanism for Oxidative Damage Repair by Thioltransferase

2002 • 45 citations

Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro

1993 • 44 citations

Mechanisms of Cataract Formation in the Human Lens

1981 • 41 citations

The Effect of H2O2 and Tertiary Butyl Hydroperoxide Upon a Murine Immortal Lens Epithelial Cell Line, αTN4-1

2002 • 41 citations

Gene expression analysis of an H2O2-resistant lens epithelial cell line

2001 • 39 citations

Differential amplification of gene expression in lens cell lines conditioned to survive peroxide stress.

2002 • 38 citations

The Effect of Photochemical Stress Upon the Lenses of Normal and Glutathione Peroxidase-1 Knockout Mice

1998 • 37 citations

Antioxidants and Oxidative Stress in Health and Disease: Introduction

1999 • 35 citations

Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate

1994 • 34 citations

The Contribution of GSH Peroxidase-1, Catalase and GSH to the Degradation of H2O2by the Mouse Lens

1997 • 34 citations

Development and characterization of an H2O2-resistant immortal lens epithelial cell line.

2000 • 32 citations

The Effect of Aging on Glutathione Peroxidase-I Knockout Mice—Resistance of the Lens to Oxidative Stress

2001 • 29 citations

The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells

2000 • 27 citations

Photodamage to the lens in vitro: Implications of the Haber-Weiss reaction

1986 • 17 citations

DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance.

1990 • 15 citations

Studies on in Vivo Degradation of Rat Hepatic Catalase with or without Modification by 3-Amino-1,2,4-triazole

1974 • 12 citations

A Forty-Two Year Voyage Through Vision Research

2000 • 8 citations

Appendix—Kinetics of irreversible inhibition of catalase

1960 • 8 citations

Global Gene Expression Analysis of Lens Cell Lines Conditioned to Survive Various Peroxide Stresses

2003 • 1 citations