Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Chemotaxis in Eukaryotic Cells: A Focus on Leukocytes and Dictyostelium

1988 • 623 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.

1992 • 496 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

Life at the Leading Edge: The Formation of Cell Protrusions

1993 • 442 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Cell Transformation by the Viral src Oncogene

1987 • 405 citations

Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound.

1982 • 403 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.

1992 • 368 citations

Growth factor signaling: Where is the specificity?

1992 • 341 citations

Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.

1994 • 333 citations

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

1994 • 332 citations

Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.

1979 • 325 citations

The Directed Migration of Eukaryotic Cells

1986 • 312 citations

Nerve growth factor mediates phosphorylation of specific proteins

1980 • 305 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors.

1979 • 300 citations

Extracellular Matrix 2: Role of extracellular matrix molecules and their receptors in the nervous system

1993 • 276 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor

1981 • 262 citations

Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts.

1989 • 256 citations

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.

1991 • 255 citations

Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

1992 • 243 citations

Endocytosis and recycling of the fibronectin receptor in CHO cells.

1989 • 231 citations

Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells

1985 • 226 citations

Dynamics of beta 1 integrin-mediated adhesive contacts in motile fibroblasts.

1992 • 222 citations

Multiple influences of a heparin-binding growth factor on neuronal development.

1987 • 212 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.

1991 • 202 citations

Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells.

1986 • 197 citations

Focal contacts: Transmembrane links between the extracellular matrix and the cytoskeleton

1989 • 193 citations

Alteration of cellular adhesion by nerve growth factor.

1977 • 193 citations

Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/c-3T3 cells.

1985 • 187 citations

Focal adhesion kinase: an integrin-linked protein tyrosine kinase

1993 • 177 citations

Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.

1992 • 175 citations

A neuronal cell line (PC12) expresses two β1-class integrins—α1β1, and α3β1—that recognize different neurite outgrowth-promoting domains in laminin

1990 • 174 citations

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

1994 • 171 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event.

1989 • 164 citations

Paxillin: A cytoskeletal target for tyrosine kinases

1994 • 162 citations

The effect of platelet-derived growth factor on morphology and motility of human glial cells

1983 • 148 citations

Rapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factor

1979 • 146 citations

Epidermal growth factor induces redistribution of actin and α-actinin in human epidermal carcinoma cells

1981 • 139 citations

A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions.

1993 • 137 citations

Rapid rounding of human epidermoid carcinoma cells A-431 induced by epidermal growth factor

1981 • 134 citations

Epidermal growth factor induces rapid reorganization of the actin microfilament system in human A431 cells

1991 • 130 citations

Actin—membrane interaction in focal adhesions

1990 • 130 citations

Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.

1993 • 122 citations

Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration.

1991 • 113 citations

Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP.

1984 • 112 citations

Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.

1993 • 108 citations

Characterization of neural cell adhesion sites: point contacts are the sites of interaction between integrins and the cytoskeleton in PC12 cells

1994 • 107 citations

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

1992 • 105 citations

Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants

1993 • 88 citations

How do cells move along surfaces?

1993 • 87 citations

Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity.

1994 • 86 citations

A negative feedback loop attenuates EGF-induced morphological changes.

1991 • 82 citations

Changes in fibroblast contractility, morphology, and adhesion in response to a phorbol ester tumor promoter

1988 • 70 citations

Cell surface dynamics of neutrophils stimulated with phorbol esters or retinoids.

1987 • 66 citations

Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C.

1991 • 61 citations

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.

1991 • 60 citations

Tumor promoter modulation of epidermal growth factor‐ and nerve growth factor‐induced adhesion and growth factor binding of PC‐12 pheochromocytoma cells

1980 • 58 citations

Nerve growth factor-induced neuronal differentiation of PC12 pheochromocytoma cells: Lack of inhibition by a tumor promoter

1982 • 53 citations

Role of protein tyrosine phosphorylation in the NGF response

1989 • 52 citations

Diacylglycerols and PMA induce actin polymerization and distinct shape changes in lymphocytes: relation to fluid pinocytosis and locomotion

1989 • 44 citations

Special type of morphological reorganization induced by phorbol ester: reversible partition of cell into motile and stable domains.

1987 • 37 citations

Cell Behaviour: Adhesion and Motility

1993 • 37 citations

Role of the cAMP‐dependent protein kinase and protein kinase C in regulating the morphological differentiation of PC12 cells

1990 • 36 citations

Interleukin-6 and 12-O-tetradecanoyl Phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells

1991 • 33 citations

Neurite extension and protein tyrosine phosphorylation elicited by inducible expression of the v-src oncogene in a PC12 cell line*1

1991 • 30 citations

Nerve growth factor induces rapid redistribution of F‐actin in PC12 cells

1988 • 28 citations

The Differential Role of Protein Kinase C Isozyme in the Rapid Induction of Neurofilament Phosphorylation by Nerve Growth Factor and Phorbol Esters in PC12 Cells

1991 • 26 citations

Rapid regulation of neuronal growth cone shape and surface morphology by nerve growth factor

1987 • 24 citations

Evidence for the recycling nature of the fibronectin receptor of macrophages

1987 • 23 citations

Synergistic effects of nerve growth factor and phorbol 12‐myristate 13‐acetate on rapid motility and process formation in PC12 cells: The role of laminin

1992 • 10 citations