Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity.

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro

1992 • 865 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1992 • 625 citations

New insights on mammalian phospholipase A ₂ (s); comparison of arachidonoyl‐selective and ‐nonselective enzymes

1993 • 443 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration.

1986 • 354 citations

Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries.

1990 • 282 citations

Human endothelial cells are chemotactic to endothelial cell growth factor and heparin.

1985 • 282 citations

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.

1991 • 255 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

1986 • 229 citations

Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.

1983 • 223 citations

Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells.

1990 • 205 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Possible Direct Linkage of Insulin-like Growth Factor-II Receptor with Guanine Nucleotide-binding Proteins

1989 • 169 citations

Regulation of production of a platelet‐derived growth factor‐like protein by cultured bovine aortic endothelial cells

1984 • 158 citations

Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.

1987 • 147 citations

SPARC antagonizes the effect of basic fibroblast growth factor on the igration of bovine aortic endothelial cells

1992 • 142 citations

Biological Activities of Fibroblast Growth Factors

1991 • 135 citations

p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor.

1991 • 121 citations

Acidic fibroblast growth factor promotes vascular repair.

1991 • 117 citations

Oxidized low density lipoprotein inhibits the migration of aortic endothelial cells in vitro.

1993 • 115 citations

Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.

1992 • 114 citations

Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils

1989 • 109 citations

A G Protein Mutant That Inhibits Thrombin and Purinergic Receptor Activation of Phospholipase A₂

1990 • 108 citations

Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes.

1988 • 107 citations

Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells

1987 • 97 citations

Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2.

1989 • 95 citations

A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. I. Identification by photolabeling or membrane and ternary complex preparation.

1990 • 91 citations

Possible involvement of a GTP-binding protein, the substrate of islet-activating protein, in receptor-mediated signaling responsible for cell proliferation.

1987 • 85 citations

Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases

1988 • 76 citations

G-protein-mediated epidermal growth factor signal transduction in a human breast cancer cell line. Evidence for two intracellular pathways distinguishable by pertussis toxin.

1988 • 71 citations

Phosphorylation-dependent regulation of phospholipase A2 by G-proteins and Ca2+ in HL60 granulocytes.

1992 • 70 citations

Evidence for the involvement of tyrosine kinases in the locomotory responses of human neutrophils

1992 • 69 citations

Effects of cytoskeletal disrupting agents on replication of bovine endothelium

1981 • 56 citations

Signal transduction by bFGF, but not TGFβ1, involves arachidonic acid metabolism in endothelial cells

1991 • 53 citations

Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. II. Two signaling pathways distinguished by pertussis toxin and a potential role for the ras oncogene.

1989 • 51 citations

The microtubular cytoskeleton and the initiation of DNA synthesis

1984 • 48 citations

Pertussis toxin inhibits the action of insulin-like growth factor-I

1987 • 46 citations

Autocrine angiotensin system regulation of bovine aortic endothelial cell migration and plasminogen activator involves modulation of proto-oncogene pp60c-src expression.

1992 • 46 citations

Is phospholipase A2 activation regulated by G-proteins?

1991 • 44 citations

Inhibition of mink lung epithelial cell proliferation by transforming growth factor-β is coupled through a pertussis-toxin-sensitive substrate

1990 • 38 citations

Studies on the mechanisms of signalling and inhibition by pertussis toxin on fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells

1991 • 25 citations

Signal transduction; a practical approach

1993 • 25 citations

Increased levels of c-fos and c-myc mRNA in ATP-stimulated endothelial cells

1990 • 22 citations

The role of G‐protein in matrix‐mediated motility of highly and poorly invasive melanoma cells

1991 • 15 citations

Possible involvement of arachidonic acid metabolites in the synergistic action of endothelial mitogenesis by basic fibroblast growth factor and phorbol ester.

1992 • 14 citations

Involvement of cyclic AMP cell surface receptors and G-proteins in signal transduction during slug migration of Dictyostelium discoideum

1991 • 9 citations

Inhibition by pertussis toxin of fibroblast growth factor-stimulated hexose transport in Swiss 3T3 cells

1987 • 7 citations

Serum factor that blocks the action of fish oils on endothelial cell production of platelet-derived growth factor is ceruloplasmin.

1992 • 7 citations

Characterization of [125I]acidic fibroblast growth factor binding to the cloned human fibroblast growth factor receptor, FGF-flg, on NIH 3T3 cell membranes: inhibitory effects of heparin, pertussis toxin and guanine nucleotides.

1992 • 4 citations