Pharmacogenetics and the serotonin system: initial studies and future directions

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

1996 • 5,154 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Neurogenetic Adaptive Mechanisms in Alcoholism

1987 • 2,300 citations

Allelic Variation of Human Serotonin Transporter Gene Expression

1996 • 2,225 citations

Association Mapping in Structured Populations

2000 • 1,990 citations

Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A

1993 • 1,620 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

The spectrum of behaviors influenced by serotonin

1998 • 1,126 citations

A functional polymorphism in the monoamine oxidase A gene promoter

1998 • 1,070 citations

Enhanced Aggressive Behavior in Mice Lacking 5-HT _1B Receptor

1994 • 823 citations

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

1998 • 802 citations

Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Serotonin Transporter-Deficient Mice

1998 • 704 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT _1A receptor mutant mice

1998 • 690 citations

Increased anxiety of mice lacking the serotonin _1A receptor

1998 • 684 citations

A Sibship Test for Linkage in the Presence of Association: The Sib Transmission/Disequilibrium Test

1998 • 674 citations

The Role of Serotonin in Antipsychotic Drug Action

1999 • 672 citations

Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine

1998 • 605 citations

A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR) and Prefrontal Cortical Binding in Major Depression and Suicide

2000 • 603 citations

Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents

1984 • 597 citations

Excess of High Activity Monoamine Oxidase A Gene Promoter Alleles in Female Patients with Panic Disorder

1999 • 592 citations

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

1999 • 572 citations

The transmission/disequilibrium test: history, subdivision, and admixture.

1995 • 555 citations

A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity

2000 • 468 citations

5-HT1A receptor agonists: recent developments and controversial issues

1995 • 463 citations

Evidence of linkage between the serotonin transporter and autistic disorder

1997 • 435 citations

Genetic Animal Models of Alcohol and Drug Abuse

1994 • 435 citations

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

1997 • 420 citations

Serotonin transporter gene polymorphism and antidepressant response

2000 • 392 citations

Cocaine, Ethanol, and Genotype Effects on Human Midbrain Serotonin Transporter Binding Sites and mRNA Levels

1998 • 390 citations

The serotonin system in autism

1996 • 389 citations

Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome

1994 • 380 citations

Suicidality and 5-Hydroxyindoleacetic Acid Concentration Associated With a Tryptophan Hydroxylase Polymorphism

1994 • 378 citations

Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine

1997 • 378 citations

A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo

1999 • 372 citations

Transmission/disequilibrium tests for quantitative traits

2000 • 358 citations

The Power of Genomic Control

2000 • 357 citations

Elevated alcohol consumption in null mutant mice lacking 5–HT1B serotonin receptors

1996 • 356 citations

Aggression, suicidality, and serotonin.

1992 • 348 citations

Mapping disease genes: family-based association studies.

1995 • 345 citations

Serotonin and Hallucinogens

1999 • 343 citations

Association between clozapine response and allelic variation in 5-HT2A receptor gene

1995 • 330 citations

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

1998 • 329 citations

Linkage of Antisocial Alcoholism to the Serotonin 5-HT1B Receptor Gene in 2 Populations

1998 • 322 citations

The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs.

1989 • 321 citations

Reduced satiating effect of d -fenfluramine in serotonin 5-HT 2C receptor mutant mice

1999 • 290 citations

Prediction of Level of Serotonin 2A Receptor Binding by Serotonin Receptor 2A Genetic Variation in Postmortem Brain Samples From Subjects Who Did or Did Not Commit Suicide

1999 • 274 citations

Serotonin transporter (5-HTT) gene variants associated with autism?

1997 • 260 citations

Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABAα6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study

1999 • 258 citations

An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells

1999 • 257 citations

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response

1998 • 254 citations

A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter

1998 • 254 citations

Population studies of polymorphisms of the serotonin transporter protein gene.

1999 • 251 citations

Role of the Serotonin Transporter Promoter Polymorphism in Anxiety-Related Traits

1998 • 248 citations

Serotonin Subtype 2 Receptor Genes and Clinical Response to Clozapine in Schizophrenia Patients

1998 • 247 citations

The recombinant 5‐HT_1A receptor: G protein coupling and signalling pathways

1999 • 232 citations

5-HT1B Receptor Knock-Out Mice Exhibit Increased Exploratory Activity and Enhanced Spatial Memory Performance in the Morris Water Maze

1999 • 227 citations

Identification, Expression, and Pharmacology of a Cys23-Ser23 Substitution in the Human 5-HT2C Receptor Gene (HTR2C)

1995 • 223 citations

Identification of polymorphic loci in the promoter region of the serotonin 5-HT 2C receptor gene and their association with obesity and Type II diabetes

2000 • 215 citations

Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder

1998 • 205 citations

Population studies of polymorphisms of the serotonin transporter protein gene

1999 • 203 citations

Increased Exploratory Activity and Altered Response to LSD in Mice Lacking the 5-HT5A Receptor

1999 • 197 citations

Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism

1999 • 196 citations

Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and association analysis in schizophrenia

1996 • 193 citations

Role of the serotonin transporter gene in the behavioral expression of autism

2001 • 193 citations

Association between clozapine response and allelic variation in the 5-HT2C receptor gene

1995 • 185 citations

Global variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3)

1999 • 184 citations

Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.

2000 • 184 citations

Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice.

1999 • 180 citations

Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients

1997 • 179 citations

Serotonin and Hallucinogens

1999 • 175 citations

Influence of a Functional Polymorphism Within the Promoter of the Serotonin Transporter Gene on the Effects of Total Sleep Deprivation in Bipolar Depression

1999 • 167 citations

Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7

1997 • 166 citations

Anxiety, motor activation, and maternal-infant interactions in 5HT-sub(1B ) knockout mice.

1999 • 166 citations

Anxiety, motor activation, and maternal–infant interactions in 5HT1B knockout mice.

1999 • 164 citations

Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites

1989 • 160 citations

Lithium response and genetics of affective disorders

1994 • 159 citations

Serotonin transporter (5-HTT) and ?-aminobutyric acid receptor subunit ?3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families

1999 • 158 citations

Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees

1998 • 155 citations

Absence of Fenfluramine-Induced Anorexia and Reduced c-fos Induction in the Hypothalamus and Central Amygdaloid Complex of Serotonin 1B Receptor Knock-Out Mice

1998 • 155 citations

Association Analysis of a Regulatory Variation of the Serotonin Transporter Gene with Severe Alcohol Dependence

1997 • 153 citations

Genetic Inactivation of the Serotonin_1AReceptor in Mice Results in Downregulation of Major GABA_AReceptor α Subunits, Reduction of GABA_AReceptor Binding, and Benzodiazepine-Resistant Anxiety

2000 • 153 citations

Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder

1998 • 149 citations

Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene

1997 • 143 citations

Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence

2000 • 143 citations

Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior

2000 • 137 citations

Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs

2000 • 128 citations

A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers

2000 • 127 citations

Serotonin and the heart

2000 • 123 citations

Contractile 5‐HT_1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry

1999 • 121 citations

Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor

1997 • 119 citations

Pharmacogenetic response to antidepressants in a multicase family with affective disorder

1994 • 116 citations

A Naturally Occurring Amino Acid Substitution of the Human Serotonin 5‐HT_2A Receptor Influences Amplitude and Timing of Intracellular Calcium Mobilization

1997 • 113 citations

Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples

2000 • 112 citations

A Family‐Based Analysis of Whether the Functional Promoter Alleles of the Serotonin Transporter Gene HTT Affect the Risk for Alcohol Dependence

1998 • 106 citations

Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter

1999 • 105 citations

Is the 5-HT_1DβReceptor Gene Implicated in the Pathogenesis of Obsessive-Compulsive Disorder?

2000 • 103 citations

Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains

1995 • 101 citations

Pharmacogenetics of antidepressants: clinical aspects

1997 • 100 citations

Association analysis of the 5-HT5A gene in depression, psychosis and antipsychotic response

2000 • 95 citations

Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine

2000 • 94 citations

Identification of four variants in the tryptophan hydroxylase promoter and association to behavior

1999 • 93 citations

Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A

1999 • 91 citations

High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene

1998 • 89 citations

Effect of 5-HT4 receptor stimulation on the pacemaker current If in human isolated atrial myocytes

1998 • 88 citations

Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine

2000 • 86 citations

Two naturally occurring amino acid substitutions of the 5-HT2A receptor: Similar prevalence in patients with seasonal affective disorder and controls

1996 • 86 citations

Association Between Drinking‐Related Antisocial Behavior and a Polymorphism in the Serotonin Transporter Gene in a Japanese Population

1999 • 85 citations

Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence

1999 • 85 citations

Current and Emerging Second‐Generation Triptans in Acute Migraine Therapy: A Comparative Review

2000 • 84 citations

Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice

2000 • 82 citations

Clozapine response and the 5HT2C Cys23Ser polymorphism

1996 • 80 citations

Pindolol augmentation of antidepressant therapy

1998 • 80 citations

A logistic regression based extension of the TDT for continuous and categorical traits

1999 • 80 citations

5‐Hydroxytryptamine and functional bowel disorders

1996 • 78 citations

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors

1999 • 76 citations

Correlation of length of VNTR alleles at the X-linked MAOA gene and phenotypic effect in Tourette syndrome and drug abuse

1998 • 75 citations

Outcomes on lithium treatment as a tool for genetic studies in affective disorders

1984 • 72 citations

Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan

1996 • 68 citations

Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders

2000 • 68 citations

Serotonin transporter (5-HTT) gene and bipolar affective disorder.

1998 • 63 citations

Serotonin 5‐HT_2C Receptor Stimulates Cyclic GMP Formation in Choroid Plexus

1995 • 61 citations

HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses

1999 • 57 citations

Agonist-Promoted Down-Regulation and Functional Desensitization in Two Naturally Occurring Variants of the Human Serotonin1A Receptor

1997 • 56 citations

Serotonin transporter (5-HTT) gene and bipolar affective disorder

1998 • 55 citations

Effect of 5-HT1B Receptor Ligands on Self-administration of Ethanol in an Operant Procedure in Rats

2000 • 52 citations

Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings

2000 • 51 citations

2 Naturally Occurring Amino Acid Substitutions in the Human 5-HT1A Receptor: Glycine 22 to Serine 22 and Isoleucine 28 to Valine 28

1995 • 51 citations

MAOA

1999 • 51 citations

Transmission/disequilibrium tests for quantitative traits

2000 • 50 citations

Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium

1998 • 49 citations

No association or linkage between the 5-HT2a/T102C polymorphism and schizophrenia in Irish families

1997 • 47 citations

Family-based association study between bipolar disorder andDRD2, DRD4, DAT, andSERT in Sardinia

1999 • 47 citations

Effects of physical training on functional activity of 5-HT 1B receptors in rat central nervous system: role of 5-HT-moduline

2000 • 43 citations

Bipolar disorder and the serotonin transporter gene: a family-based association study

1999 • 43 citations

Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity.

1999 • 42 citations

Physical mapping of the serotonin 5-HT7 receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium betweenHTR7 and autistic disorder

1999 • 39 citations

Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor

1999 • 37 citations

Serotonin_2C Receptors and Serotonin_2C Receptor‐Mediated Phosphoinositide Hydrolysis in the Brain of Alcohol‐Preferring and Alcohol‐Nonpreferring Rats

1996 • 37 citations

5-Hydroxytryptamine-moduline: a novel endogenous peptide involved in the control of anxiety

1999 • 35 citations

Behavioral effects of tryptophan depletion in seasonal affective disorder associated with the serotonin transporter gene?

1999 • 34 citations

Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder

2000 • 34 citations

Molecular Genetics of Substance Abuse Vulnerability A Current Approach

1999 • 33 citations

Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity

1999 • 31 citations

PHARMACOLOGICAL PROPERTIES OF A NOVEL GASTROINTESTINAL PROKINETIC BENZAMIDE SELECTIVE FOR HUMAN 5-HT4RECEPTORVERSUSHUMAN 5-HT3RECEPTOR

1999 • 29 citations

The 5′ region of the tryptophan hydroxylase gene: mutation search and association study with alcoholism

1999 • 26 citations

An Association Study Between Alcoholism and the Serotonergic Receptor Genes

2000 • 24 citations

Ondansetron--the first of a new class of antiemetic agents.

1991 • 23 citations

Pharmacogenetics: Promise and Potential in Child and Adolescent Psychiatry

2000 • 23 citations

Binding properties of the naturally occurring human 5-HT1A receptor variant with the Ile28Val substitution in the extracellular domain

1995 • 21 citations

Possible relationship between outcome in primary affective disorders treated with lithium and family history.

1982 • 18 citations

Genetic Animal Models

2014 • 16 citations

Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders

1995 • 10 citations