AN APPETITE FOR APOPTOTIC CELLS? CONTROVERSIES AND CHALLENGES

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

CD44 and Its Interaction with Extracellular Matrix

1993 • 1,082 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

Cytokines in context.

1991 • 808 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

1993 • 726 citations

Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

1998 • 692 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.

1995 • 675 citations

CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

1998 • 668 citations

CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells

1997 • 662 citations

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited.

1997 • 661 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane.

1975 • 595 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

Integrin signaling: specificity and control of cell survival and cell cycle progression

1997 • 474 citations

Impairment of function in aging neutrophils is associated with apoptosis.

1993 • 467 citations

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition

1999 • 461 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Wound repair in the context of extracellular matrix

1994 • 435 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.

1996 • 423 citations

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

1991 • 415 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension

1999 • 414 citations

CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

1995 • 392 citations

Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells

1998 • 385 citations

Recognizing death: the phagocytosis of apoptotic cells

1998 • 381 citations

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

1998 • 377 citations

Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor

1993 • 348 citations

DOCK180, a Major CRK-Binding Protein, Alters Cell Morphology upon Translocation to the Cell Membrane

1996 • 339 citations

Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression.

1994 • 333 citations

Regulated nuclear import of Rel proteins in the Drosophila immune response

1998 • 314 citations

Fibronectin is produced by human macrophages.

1980 • 311 citations

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism.

1989 • 298 citations

The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death.

1996 • 294 citations

Glucocorticoids Promote Nonphlogistic Phagocytosis of Apoptotic Leukocytes

1999 • 292 citations

Induction of Apoptosis and Pulmonary Fibrosis in Mice in Response to Ligation of Fas Antigen

1997 • 289 citations

Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2

1992 • 284 citations

The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters

1998 • 278 citations

Macrophage recruitment during limb development and wound healing in the embryonic and foetal mouse

1994 • 274 citations

Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes

1999 • 274 citations

Eosinophil apoptosis and the resolution of airway inflammation in asthma.

1996 • 267 citations

The selective engulfment of apoptotic bodies by dendritic cells is mediated by the αvβ3 integrin and requires intracellular and extracellular calcium

1997 • 262 citations

Exposure of Phosphatidylethanolamine on the Surface of Apoptotic Cells

1997 • 247 citations

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.

1998 • 246 citations

Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response.

1996 • 244 citations

Differences in the Mode of Phagocytosis with Fc and C3 Receptors in Macrophages

1977 • 239 citations

Granulocyte apoptosis and the control of inflammation

1994 • 232 citations

Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions*1

1987 • 216 citations

Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin.

1994 • 213 citations

Binding and Phagocytosis of Apoptotic Vascular Smooth Muscle Cells Is Mediated in Part by Exposure of Phosphatidylserine

1995 • 208 citations

Hormone-induced cell death. 2. Surface changes in thymocytes undergoing apoptosis.

1984 • 207 citations

Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells

2007 • 201 citations

Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans

1998 • 199 citations

Signaling through CD44 Is Mediated by Tyrosine Kinases

1996 • 189 citations

The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor

1992 • 185 citations

Macrophage Recognition of ICAM-3 on Apoptotic Leukocytes

1999 • 183 citations

Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids.

1996 • 168 citations

Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis.

1995 • 168 citations

Integrins as promiscuous signal transduction devices

1996 • 165 citations

Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes.

1988 • 162 citations

Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages.

1984 • 160 citations

Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis

1995 • 158 citations

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

1996 • 158 citations

Phagocytosis of apoptotic bodies by liver endothelial cells

1995 • 157 citations

Isolation of the phagocytosis-inducing IgG-binding antigen on senescent somatic cells

1981 • 157 citations

CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages.

1997 • 150 citations

Regulation of Macrophage Phagocytosis of Apoptotic Cells by cAMP

1998 • 149 citations

Immune Clearance of Phosphatidylserine-expressing Cells by Phagocytes

1997 • 148 citations

Antineutrophil Cytoplasmic Autoantibodies Interact with Primary Granule Constituents on the Surface of Apoptotic Neutrophils in the Absence of Neutrophil Priming

1996 • 147 citations

Characterization of Phosphatidylserine-dependent β2-Glycoprotein I Macrophage Interactions

1998 • 146 citations

Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells.

1993 • 140 citations

Recognition of Phosphatidylserine on the Surface of Apoptotic Spermatogenic Cells and Subsequent Phagocytosis by Sertoli Cells of the Rat

1997 • 139 citations

Multiple systems for recognition of apoptotic lymphocytes by macrophages.

1997 • 133 citations

Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion.

1997 • 131 citations

Ligated complement receptors do not activate the arachidonic acid cascade in resident peritoneal macrophages.

1985 • 128 citations

The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide

1994 • 123 citations

Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells

1999 • 121 citations

Recognition of apoptotic cells by human macrophages: inhibition by a monocyte/macrophage‐specific monoclonal antibody

1994 • 118 citations

Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis.

1991 • 113 citations

Programmed cell death in invertebrates

1996 • 102 citations

Phosphatidylserine Receptors: Role of CD36 in Binding of Anionic Phospholipid Vesicles to Monocytic Cells

1999 • 95 citations

Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte–derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H2O2

1998 • 86 citations

CD66: role in the regulation of neutrophil effector function

1996 • 84 citations

Human Kupffer Cell Recognition and Phagocytosis of Apoptotic Peripheral Blood Lymphocytes

1996 • 83 citations

Phosphatidylinositol 3-Kinase Association with the Osteoclast Cytoskeleton, and Its Involvement in Osteoclast Attachment and Spreading

1997 • 82 citations

Recognition of apoptotic cells by phagocytes

1996 • 79 citations

Distinct Involvement of β3 Integrin Cytoplasmic Domain Tyrosine Residues 747 and 759 in Integrin-mediated Cytoskeletal Assembly and Phosphotyrosine Signaling

1998 • 77 citations

Protein tyrosine phosphorylation induced via the IgG receptors Fc gamma Ri and Fc gamma RII in the human monocytic cell line THP-1.

1992 • 75 citations

Previous Uptake of Apoptotic Neutrophils or Ligation of Integrin Receptors Downmodulates the Ability of Macrophages to Ingest Apoptotic Neutrophils

1999 • 72 citations

Contribution of induced magnetization to magnetization of seamounts

1989 • 71 citations

Apoptosis and Secondary Necrosis of Lymphocytes in Culture

1997 • 67 citations

Human and Murine High Endothelial Venule Cells Phagocytose Apoptotic Leukocytes

1997 • 57 citations

Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin.

1998 • 52 citations

A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells.

1999 • 48 citations

Aggregation of macrophages in the tips of intestinal villi in guinea pigs: their possible role in the phagocytosis of effete epithelial cells

1993 • 46 citations

A Novel β1 Integrin-Dependent Mechanism of Leukocyte Adherence to Apoptotic Cells

1999 • 41 citations

Roles of ICAM-3 and CD 14 in the recognition and phagocytosis of apoptotic cells by macrophages

1998 • 40 citations

Tyrosine kinase‐dependent activation of human NK cell functions upon triggering through CD44 receptor

1996 • 30 citations

Defective Phagocytosis of Apoptotic Cells: Possible Explanation for the Induction of Autoantibodies in SLE

1997 • 25 citations

Class A scavenger receptors and the phagocytosis of apoptotic cells

1998 • 17 citations

Loss and shedding of surface markers from the leukemic myeloid monocytic line THP-1 induced to undergo apoptosis

1996 • 13 citations

Posttranslational modifications of brain and erythrocyte band 3 during aging and disease.

1996 • 12 citations

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