Binding and Phagocytosis of Apoptotic Vascular Smooth Muscle Cells Is Mediated in Part by Exposure of Phosphatidylserine

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques.

1995 • 700 citations

Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

1987 • 699 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes.

1991 • 590 citations

Evidence for apoptosis in human atherogenesis and in a rat vascular injury model.

1995 • 484 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro

1995 • 435 citations

Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets.

1990 • 372 citations

In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes.

1985 • 352 citations

Transbilayer movement of phospholipids in red cell and platelet membranes

1991 • 317 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Phospholipid binding properties of human placental anticoagulant protein-I, a member of the lipocortin family

1989 • 312 citations

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

1995 • 293 citations

Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages.

1990 • 231 citations

Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation

1990 • 230 citations

Maintenance and consequences of membrane phospholipid asymmetry

1994 • 218 citations

Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin.

1994 • 213 citations

Hormone-induced cell death. 2. Surface changes in thymocytes undergoing apoptosis.

1984 • 207 citations

Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by serum reduction, interferon-gamma, heparin, and cyclic nucleotide analogues and induces apoptosis.

1994 • 200 citations

Apoptosis (Programmed Cell Death) in Arteries of the Neonatal Lamb

1995 • 200 citations

Calcium induces transbilayer redistribution of all major phospholipids in human erythrocytes

1992 • 195 citations

The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor

1992 • 185 citations

Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles.

1991 • 168 citations

Gene Transfer and Expression Protocols

1991 • 165 citations

Measurement of membrane phospholipid asymmetry in normal and sickle-cell erythrocytes by means of annexin V binding.

1994 • 158 citations

Apoptosis of Rat Vascular Smooth Muscle Cells Is Regulated by p53-Dependent and -Independent Pathways

1995 • 155 citations

Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein.

1994 • 151 citations

Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes.

1985 • 151 citations

A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells.

1995 • 144 citations

Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells.

1993 • 140 citations

Phosphatidylserine as a determinant of reticuloendothelial recognition of liposome models of the erythrocyte surface.

1988 • 137 citations

Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells

1990 • 119 citations

Partial purification and characterization of the human erythrocyte Mg²⁺ ‐ATPase A candidate aminophospholipid translocase

1990 • 114 citations

Calcium-induced transbilayer scrambling of fluorescent phospholipid analogs in platelets and erythrocytes

1994 • 110 citations

Binding of annexin V to a human ovarian carcinoma cell line (OC-2008). Contrasting effects on cell surface factor VIIa/tissue factor activity and prothrombinase activity

1992 • 87 citations

Maintenance of lipid asymmetry in red blood cells and ghosts: effect of divalent cations and serum albumin on the transbilayer distribution of phosphatidylserine

1990 • 85 citations

Alteration of the aminophospholipid translocase activity during in vivo and artificial aging of human erythrocytes

1990 • 80 citations

Requirement for phosphatidylinositol 4,5-bisphosphate in the Ca(2+)-induced phospholipid redistribution in the human erythrocyte membrane.

1994 • 75 citations

Lupus Anticoagulant Autoantibody Induces Apoptosis in Umbilical Vein Endothelial Cells: Involvement of Annexin V

1994 • 72 citations

Transbilayer mobility and distribution of red cell phospholipids during storage.

1993 • 60 citations

Evidence that the scavenger receptor is not involved in the uptake of negatively charged liposomes by cells

1992 • 48 citations

Site-specific mutagenesis of annexin V: Role of residues from Arg-200 to Lys-207 in phospholipid binding

1991 • 27 citations

Choice and Manipulation of Retroviral Vectors

2003 • 27 citations