Attenuation of Th1 Effector Cell Responses and Susceptibility to Experimental Allergic Encephalomyelitis in Histamine H2 Receptor Knockout Mice Is Due to Dysregulation of Cytokine Production by Antigen-Presenting Cells

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

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Inflammatory mediators and modulation of blood-brain barrier permeability.

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THE INFLUENCE OF THE PROINFLAMMATORY CYTOKINE, OSTEOPONTIN, ON AUTOIMMUNE DEMYELINATING DISEASE

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Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis

2001 • 589 citations

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

2001 • 578 citations

Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals

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IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

1998 • 448 citations

Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis

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The mononuclear phagocyte system revisited

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Mice lacking histidine decarboxylase exhibit abnormal mast cells

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Histamine Potently Suppresses Human IL-12 and Stimulates IL-10 Production via H2 Receptors

1998 • 372 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 312 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 292 citations

Histamine Polarizes Human Dendritic Cells into Th2 Cell-Promoting Effector Dendritic Cells

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Trends in histamine research: new functions during immune responses and hematopoiesis

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Immune regulation by histamine

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Monocyte Chemoattractant Protein‐1 (CCL2) in Inflammatory Disease and Adaptive Immunity: Therapeutic Opportunities and Controversies

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The Diverse Roles of Mast Cells

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Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

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Acute experimental autoimmune encephalomyelitis in mice

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Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density.

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An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

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Mast cell activation and migration to lymph nodes during induction of an immune response in mice.

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Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7- 1, B7-2 and CD28

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Monocyte Chemoattractant Protein-1 (CCL2) in Inflammatory Disease and Adaptive Immunity: Therapeutic Opportunities and Controversies

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Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor–deficient mice

2000 • 162 citations

Pertussis Toxin Modulates the Immune Response to Neuroantigens Injected in Incomplete Freund’s Adjuvant: Induction of Th1 Cells and Experimental Autoimmune Encephalomyelitis in the Presence of High Frequencies of Th2 Cells

2002 • 159 citations

Identification of Bphs , an Autoimmune Disease Locus, as Histamine Receptor H ₁

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Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation

1995 • 145 citations

IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glycoprotein 35–55 induced experimental autoimmune encephalomyelitis

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Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination

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Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis

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Augmentation of Antigen Receptor–mediated Responses by Histamine H1 Receptor Signaling

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Identification of Genetic Loci Controlling the Characteristics and Severity of Brain and Spinal Cord Lesions in Experimental Allergic Encephalomyelitis

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Identification of IgE-positive cells and mast cells in frozen sections of multiple sclerosis brains

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Histamine Receptors: Specific Ligands, Receptor Biochemistry, and Signal Transduction

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Pertussis Toxin Enhances Th1 Responses by Stimulation of Dendritic Cells

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Hydroxyzine inhibits experimental allergic encephalomyelitis (EAE) and associated brain mast cell activation

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The role of mast cells in allergy and autoimmunity

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Role of type 1 and type 2 T helper cells in allergic diseases

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The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells

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Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin

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Monocyte Chemoattractant Protein-1 Selectively Inhibits the Acquisition of CD40 Ligand-Dependent IL-12-Producing Capacity of Monocyte-Derived Dendritic Cells and Modulates Th1 Immune Response

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Bidirectional communication between histamine and cytokines

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Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis

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Senescent Jejunal Mast Cells and Eosinophils in the Mouse Preferentially Translocate to the Spleen and Draining Lymph Node, Respectively, During the Recovery Phase of Helminth Infection

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Pertussis Toxin-Induced Reversible Encephalopathy Dependent on Monocyte Chemoattractant Protein-1 Overexpression in Mice

2002 • 61 citations

Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFα and IL-12 by macrophages via H2-receptors

2001 • 57 citations

Ueber das Vorkommen der sogenannten „Mastzellen” bei pathologischen Veränderungen des Gehirns

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Activation of histamine H2 receptors ameliorates experimental allergic encephalomyelitis

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Indirect IL-4 Pathway in Type 1 Immunity

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The effects of histamine on interferon gamma production are dependent on the stimulatory signals

2001 • 33 citations

Histamine deficiency induces tissue‐specific down‐regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice

2001 • 29 citations

Regulation of phospholipase C activation by the number of H2 receptors during Ca2+-induced differentiation of mouse keratinocytes

2002 • 26 citations

Analysis of the Role ofBphs/Hrh1in the Genetic Control of Responsiveness to Pertussis Toxin

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Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity

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The influence of cinanserin and selected pharmacologic agents on experimental allergic encephalomyelitis (EAE).

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Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity

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Cimetidine as modulator of the cell‐mediated immune response in vivo using the tuberculin skin test as parameter.

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Effect of selective IL-6 inhibitor Am-80 on experimental autoimmune encephalomyelitis in DA rats.

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Aggravation of experimental allergic encephalomyelitis by cimetidine

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