Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

2002 • 1,644 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

THE INFLUENCE OF THE PROINFLAMMATORY CYTOKINE, OSTEOPONTIN, ON AUTOIMMUNE DEMYELINATING DISEASE

2002 • 729 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.

1998 • 622 citations

Multiple sclerosis: a two-stage disease

2001 • 602 citations

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

2001 • 578 citations

Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice

1996 • 452 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis

2000 • 427 citations

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

1997 • 363 citations

Validation of Array-Based Gene Expression Profiles by Real-Time (Kinetic) RT-PCR

2001 • 321 citations

Pathways of anaphylaxis in the mouse

2002 • 303 citations

Molecular mechanisms of sleep‐wake regulation: roles of prostaglandins D ₂ and E ₂

1991 • 242 citations

Multiple Sclerosis: Deeper Understanding of Its Pathogenesis Reveals New Targets for Therapy

2002 • 242 citations

Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice

2002 • 225 citations

Acute experimental autoimmune encephalomyelitis in mice

1982 • 207 citations

Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets

2000 • 202 citations

Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients

1995 • 195 citations

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

2001 • 187 citations

Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes.

1982 • 162 citations

Studies on a Capillary-Rich Fraction Isolated from Brain: Histaminic Components and Characterization of the Histamine Receptors Linked to Adenylate Cyclase

1980 • 152 citations

Identification of Bphs , an Autoimmune Disease Locus, as Histamine Receptor H ₁

2002 • 149 citations

Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7.

1992 • 144 citations

Combination of Gene Delivery and DNA Vaccination to Protect from and Reverse Th1 Autoimmune Disease via Deviation to the Th2 Pathway

2001 • 142 citations

Induction of a Multiple Sclerosis-Like Disease in Mice with an Immunodominant Epitope of Myelin Oligodendrocyte Glycoprotein

1998 • 139 citations

Fibronectin in multiple sclerosis lesions.

1989 • 132 citations

Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases.

1994 • 129 citations

CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo.

1987 • 128 citations

Myelin-Specific Cd8 T Cells in the Pathogenesis of Experimental Allergic Encephalitis and Multiple Sclerosis

2001 • 114 citations

The Tryptase, Mouse Mast Cell Protease 7, Exhibits Anticoagulant Activity in Vivo and in Vitro Due to Its Ability to Degrade Fibrinogen in the Presence of the Diverse Array of Protease Inhibitors in Plasma

1997 • 114 citations

The mast cells of the multiple sclerosis brain

1996 • 107 citations

Mast cells in experimental allergic encephalomyelitis: characterization, distribution in the CNS and in vitro activation by myelin basic protein and neuropeptides

1994 • 98 citations

High-Resolution Semi-Quantitative Real-Time PCR without the Use of a Standard Curve

2001 • 97 citations

Fc Receptors are Critical for Autoimmune Inflammatory Damage to the Central Nervous System in Experimental Autoimmune Encephalomyelitis

2002 • 96 citations

Identification of IgE-positive cells and mast cells in frozen sections of multiple sclerosis brains

1990 • 95 citations

Hydroxyzine inhibits experimental allergic encephalomyelitis (EAE) and associated brain mast cell activation

2000 • 93 citations

The role of mast cells in the elicitation of experimental allergic encephalomyelitis.

1989 • 92 citations

Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis.

1996 • 84 citations

Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood.

1996 • 83 citations

Evidence for the existence of histamine H1- and H2-receptors on astrocytes of cultured rat central nervous system

1984 • 80 citations

Genetic Analysis of the Influence of Pertussis Toxin on Experimental Allergic Encephalomyelitis Susceptibility: An Environmental Agent Can Override Genetic Checkpoints

2000 • 79 citations

MAST CELLS IN PLAQUES OF MULTIPLE SCLEROSIS

2009 • 78 citations

ADP-Ribosyltransferase Activity of Pertussis Toxin and Immunomodulation by Bordetella pertussis

1988 • 73 citations

Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing–remitting multiple sclerosis

1999 • 72 citations

Analysis of neuronal gene expression with laser capture microdissection

2002 • 68 citations

Development of acute autoimmune encephalomyelitis in mice: Factors regulating the effector phase of the disease

1982 • 56 citations

Immunoglobulin E–dependent Active Fatal Anaphylaxis in Mast Cell–deficient Mice

1998 • 49 citations

Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains

1987 • 47 citations

Lack of Histamine Synthesis and Down-Regulation of H₁ and H₂ Receptor mRNA Levels by Dexamethasone in Cerebral Endothelial Cells

1999 • 44 citations

Suppression of cell-transferred experimental autoimmune encephalomyelitis in defibrinated Lewis rats

1996 • 40 citations

Experimental allergic orchitis in mice

1985 • 36 citations

Histamine H1-receptors mediate phosphoinositide hydrolysis in astrocyte-enriched primary cultures

1988 • 36 citations

Histamine H1-Receptors on Astrocytes in Primary Cultures: A Possible Target for Histaminergic Neurones

1991 • 24 citations

The immunopathology of acute experimental allergic encephalomyelitis. V. A light microscopic and ultrastructural immunohistochemical analysis of fibronectin and fibrinogen.

1988 • 19 citations

Physical mapping of the autoimmune disease susceptibility locus, Bphs: co-localization with a cluster of genes from the TNF receptor superfamily on mouse Chromosome 6

1999 • 15 citations

Mast cell‐derived histamine and tumour necrosis factor: Differences between SJL/J and BALB/c inbred strains of mice

1996 • 15 citations

Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model

1991 • 13 citations

Suppression of Experimental Autoimmune Encephalomyelitis by Dermatan Sulfate

1999 • 11 citations