The role of mast cells in allergy and autoimmunity

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

2002 • 1,644 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Autoimmune disease: why and where it occurs

2001 • 584 citations

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

2001 • 578 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

2002 • 496 citations

Heterogeneity of Mast Cells and Phenotypic Change Between Subpopulations

1989 • 484 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis

2000 • 427 citations

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

2002 • 384 citations

Identification of a Committed Precursor for the Mast Cell Lineage

1996 • 379 citations

The diverse potential effector and immunoregulatory roles of mast cells in allergic disease

2000 • 361 citations

Mechanisms for the induction of autoimmunity by infectious agents

2001 • 354 citations

Mechanisms for the induction of autoimmunity by infectious agents

2001 • 340 citations

Substance P selectively activates TNF-alpha gene expression in murine mast cells.

1993 • 333 citations

Evidence for a Role of Mast Cells in the Evolution to Congestive Heart Failure

2002 • 237 citations

Mast cells in the brain: evidence and functional significance

1996 • 229 citations

Complement Peptides C3a- and C5a-Induced Mediator Release from Dissociated Human Skin Mast Cells

1994 • 221 citations

Genetically mast-cell-deficient W/Wv and Sl/Sld mice. Their value for the analysis of the roles of mast cells in biologic responses in vivo.

1987 • 206 citations

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

2001 • 201 citations

Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients

1995 • 195 citations

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

2001 • 187 citations

Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells.

1995 • 182 citations

Mast cell activation and migration to lymph nodes during induction of an immune response in mice.

1998 • 173 citations

Distribution, activation and tryptase/chymase phenotype of mast cells in the rheumatoid lesion.

1995 • 156 citations

Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion

1999 • 151 citations

Cutting Edge: VacA, a Vacuolating Cytotoxin of Helicobacter pylori, Directly Activates Mast Cells for Migration and Production of Proinflammatory Cytokines

2002 • 151 citations

C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils

2002 • 138 citations

Mast cell responses in rheumatoid synovium. Association of the MC_TC subset with matrix turnover and clinical progression

1997 • 128 citations

Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice.

1994 • 125 citations

Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta.

1998 • 112 citations

Interactions of mast cells with the nervous system ?Recent advances

1992 • 112 citations

The mast cells of the multiple sclerosis brain

1996 • 107 citations

The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation

1988 • 106 citations

Mast cells in experimental allergic encephalomyelitis: characterization, distribution in the CNS and in vitro activation by myelin basic protein and neuropeptides

1994 • 98 citations

Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells.

1990 • 91 citations

Synovial mast cell responses during clinical improvement in early rheumatoid arthritis

1998 • 90 citations

Regulation of T Lymphocyte Trafficking into Lymph Nodes During an Immune Response by the Chemokines Macrophage Inflammatory Protein (MIP)-1α and MIP-1β

1998 • 87 citations

Autoimmunity through infection or immunization?

2001 • 78 citations

Activating and inhibitory signaling in mast cells: New opportunities for therapeutic intervention?

2000 • 67 citations

Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis

1996 • 64 citations

Senescent Jejunal Mast Cells and Eosinophils in the Mouse Preferentially Translocate to the Spleen and Draining Lymph Node, Respectively, During the Recovery Phase of Helminth Infection

2000 • 63 citations

Association of mast cells with fibrosis and fatty infiltration in the minor salivary glands of patients with Sjögren's syndrome.

1998 • 61 citations

Mast Cell and Basophil Development

2001 • 61 citations

An Analysis of Mast Cell Frequency in the Rodent Nervous System: Numbers Vary between Different Strains and Can Be Reconstituted in Mast Cell-Deficient Mice

1991 • 57 citations

Mast cell proteases liberate stable encephalitogenic fragments from intact myelin

1991 • 44 citations

Delayed Onset of Experimental Allergic Neuritis in Rats Treated with Reserpine

1984 • 40 citations

Indirect IL-4 Pathway in Type 1 Immunity

2002 • 38 citations

Treatment of experimental allergic neuritis with nedocromil sodium

1989 • 36 citations

Detection and quantitation of stem cell factor (kit ligand) in the synovial fluid of patients with rheumatic disease.

2000 • 13 citations