Pharmacokinetic Drug Interactions of Macrolides

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Meyler's Side Effects of Drugs

1976 • 717 citations

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1985 • 301 citations

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture.

1986 • 177 citations

Inhibition of theophylline clearance by troleandomycin

1977 • 170 citations

New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy

1989 • 160 citations

New directions for macrolide antibiotics: structural modifications and in vitro activity

1989 • 158 citations

Pharmacokinetic Drug Interactions with Cyclosporin (Part I)1

1990 • 154 citations

Troleandomycin: Effectiveness in steroid-dependent asthma and bronchitis

1974 • 153 citations

The use of macrolide antibiotic substances in the treatment of asthma

1970 • 151 citations

Pharmacokinetic Interactions of the Macrolide Antibiotics

1985 • 142 citations

Roxithromycin

1989 • 140 citations

Inhibition of methylprednisolone elimination in the presence of clarithromycin therapy

1999 • 127 citations

The effect of troleandomycin on methylprednisolone elimination

1980 • 122 citations

Dual effects of macrolide antibiotics on rat liver cytochrome P-450

1983 • 116 citations

Clinical Pharmacokinetic Properties of the Macrolide Antibiotics

1989 • 113 citations

Evaluation of cyclosporin‐phenytoin interaction with observations on cyclosporin metabolites.

1984 • 112 citations

Efficacy of troleandomycin in outpatients with severe, corticosteroid-dependent asthma

1980 • 108 citations

Inhibition of mixed-function oxidations by substrates forming reduced cytochrome P-450 metabolic-intermediate complexes

1977 • 105 citations

Effects of erythromycin on hepatic drug-metabolizing enzymes in humans

1983 • 104 citations

Drug interactions and hepatitis produced by some macrolide antibiotics

1985 • 99 citations

Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450

1981 • 98 citations

Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humans

1982 • 88 citations

Effect of erythromycin on carbamazepine kinetics

1983 • 86 citations

Inhibition of alfentanil metabolism by erythromycin

1989 • 84 citations

Effect of erythromycin on theophylline kinetics

1981 • 83 citations

Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides.

1989 • 81 citations

Cyclosporin‐erythromycin interaction in renal transplant patients.

1989 • 81 citations

Effect of erythromycin base on theophylline kinetics

1981 • 78 citations

Effects of three antibiotics on theophylline kinetics

1979 • 75 citations

A Pharmacokinetic Drug Interaction Between Erythromycin and Triazolam

1986 • 75 citations

EXACERBATION OF CYCLOSPORINE TOXICITY BY CONCOMITANT ADMINISTRATION OF ERYTHROMYCIN

1987 • 70 citations

Depression of theophylline elimination by erythromycin

1981 • 61 citations

Clinical Pharmacokinetic Properties of the Macrolide Antibiotics

1989 • 60 citations

Carbamazepine Intoxication Due to Triacetyloleandomycin Administration in Epileptic Patients

1980 • 58 citations

Dose- and time-related effect of troleandomycin on methylprednisolone elimination

1982 • 58 citations

Cyclosporin-erythromycin interaction in normal subjects.

1987 • 58 citations

Potentially fatal interaction between erythromycin and disopyramide

1989 • 55 citations

Digoxin toxicity due to interaction of digoxin with erythromycin.

1989 • 53 citations

Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro.

1983 • 53 citations

Effect of erythromycin in patients receiving long-term warfarin therapy.

1989 • 52 citations

The use of triacetyloleandomycin in chronic infectious asthma.

1958 • 52 citations

Steroid-specific and anticonvulsant interaction aspects of troleandomycin-steroid therapy

1982 • 52 citations

Effect of erythromycin on theophylline clearance in asthmatic children

1981 • 52 citations

The Effect of Erythromycin on the Disposition Kinetics of Warfarin

1984 • 51 citations

Troleandomycin-triazolam interaction in healthy volunteers: Pharmacokinetic and psychometric evaluation

1987 • 47 citations

A study of the interaction of roxithromycin with theophylline and carbarmazepine

1987 • 44 citations

Erythromycin's Effect on Theophylline Blood Level

1977 • 44 citations

Carbamazepine-Erythromycin Interaction

1986 • 43 citations

Possible Warfarin-Erythromycin Interaction

1980 • 42 citations

A model to detect interactions between roxithromycin and oral contraceptives

1990 • 42 citations

The macrolide revival: Thirty five years after erythromycin

1987 • 42 citations

Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: Influence of erythromycin

1982 • 41 citations

In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: Comparison with troleandomycin and erythromycin

1988 • 38 citations

Carbamazepine Toxicity Induced by Concurrent Erythromycin Therapy

1985 • 38 citations

The interaction of erythromycin with theophylline

1987 • 38 citations

Precipitation of acute ergotism by triacetyloleandomycin.

1969 • 38 citations

Pharmacokinetic evaluation of erythromycin and caffeine administered with bromocriptine

1990 • 37 citations

Pharmacokinetic interaction between theophylline and erythromycin.

1982 • 37 citations

Selection of an oral erythromycin product

1980 • 36 citations

The Effects of Erythromycin on Theophylline Elimination in Normal Males

1982 • 35 citations

The Effect of Erythromycin on Theophylline Pharmacokinetics in Chronic Bronchitis^1,2

1983 • 34 citations

Warfarin Interaction With Erythromycin

1984 • 34 citations

Interaction Between Erythromycin and Cyclosporine in a Kidney and Pancreas Allograft Recipient

1987 • 33 citations

Pharmacokinetic drug interactions with macrolide antibiotics

1985 • 30 citations

Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin.

1982 • 29 citations

Severe carbamazepine intoxication after coadministration of erythromycin

1986 • 29 citations

No Effect of Roxithromycin on Pharmacokinetic or Pharmacodynamic Properties of Warfarin and its Enantiomers

1988 • 29 citations

The Effect of Erythromycin on Theophylline Pharmacokinetics at Steady State

1982 • 28 citations

Interaction between cyclosporin and erythromycin in a kidney transplant patient

1986 • 27 citations

Antibiotics annual 1958-1959.

1959 • 27 citations

Infectious asthma treated with triacetyloleandomycin.

1961 • 26 citations

Heart block secondary to erythromycin-induced carbamazepine toxicity.

1987 • 26 citations

INFLUENCE OF ERYTHROMYCIN ON CYCLOSPORINE PHARMACOKINETICS

1987 • 25 citations

Effect of ponsinomycin on cyclosporin pharmacokinetics

1990 • 25 citations

Effect of Ponsinomycin on Single-Dose Kinetics and Metabolism of Carbamazepine

1990 • 24 citations

The effects of erythromycin on the absorption and disposition kinetics of theophylline

1981 • 24 citations

Interaction Between Roxithromycin and Cyclosporin in Heart Transplant Patients

1990 • 24 citations

Interaction of Theophylline with Erythromycin Base in a Patient with Seizure Activity

1983 • 22 citations

Effects of josamycin on carbamazepine kinetics

1987 • 22 citations

[Delay in elimination of theophylline due to troleandomycin. No effect of josamycin (author's transl)].

1980 • 22 citations

The Theophylline-Erythromydn Interaction

1988 • 22 citations

Changes in the Steady‐State Pharmacokinetics of Theophylline During Treatment with Dirithromycin

1990 • 22 citations

Decrease in a constitutive form of cytochrome P-450 by macrolide antibiotics

1989 • 20 citations

Erythromycin—Oral Anticoagulants Interaction

1986 • 19 citations

Lack of effect of erythromycin on the pharmacokinetics of single oral doses of phenytoin.

1988 • 18 citations

Severe Intrahepatic Cholestasis Due to the Combined Intake of Oral Contraceptives and Triacetyloleandomycin

1983 • 17 citations

[Influence of a new macrolide, midecamycin on theophylline pharmacokinetics (author's transl)].

1981 • 17 citations

Lack of effect of spiramycin on cyclosporin pharmacokinetics [see comments]

1989 • 16 citations

A case of erythromycin-induced carbamazepine toxicity.

1986 • 16 citations

Pharmacokinetics of roxithromycin in renal and hepatic failure and drug interactions

1987 • 15 citations

Ergotism with therapeutic doses of ergotamine tartrate.

1979 • 15 citations

Impact of Rokitamycin, a New 16-Membered Macrolide, on Serum Theophylline

1991 • 15 citations

Comparative liver toxicity of various erythromycin derivatives in animals

1988 • 15 citations

Spiramycin: safety in man

1988 • 15 citations

CARBAMAZEPINE INTOXICATION FOLLOWING THE USE OF ERYTHROMYCIN IN CHILDREN

1987 • 15 citations

Effect of miocamycin on theophylline kinetics in children

1987 • 14 citations

The interaction between carbamazepine and erythromycin

1989 • 14 citations

Effect of flurithromycin, a new macrolide antibiotic, on carbamazepine disposition in normal subjects.

1988 • 14 citations

Lack of effect of ponsinomycin on the plasma pharmacokinetics of theophylline

1989 • 14 citations

Cholestatic jaundice after triacetyloleandomycin and oral contraceptives. The diagnostic value of gamma-glutamyl transpeptidase.

1980 • 14 citations

Interaction of erythromycin with cyclosporine.

1988 • 12 citations

Single dose phenytoin clearance during erythromycin treatment.

1984 • 12 citations

Lack of clinically important interaction between erythromycin and theophylline

1984 • 12 citations

The effects of spiramycin on plasma cyclosporin A concentrations in heart transplant patients

1989 • 11 citations

Effects of a new fluorinated macrolide (P-0501A) and other erythromycins on drug metabolizing enzymes in rat liver.

1986 • 11 citations

Steady State Urinary Excretion of Theophylline and its Metabolities in the Presence of Erythromycin

1982 • 11 citations

[Influence of josamycine treatment on carbamazepine kinetics (author's transl)].

1982 • 11 citations

Decrease in Theophylline Clearance after the Administration of Erythromycin to a Patient with Obstructive Lung Disease

1983 • 11 citations

Spiramycin has no effect on serum theophylline in asthmatic patients

1986 • 10 citations

Interaction of dihydroergotamine and triacetyloleandomycin in the minipig

1983 • 10 citations

[Drug interactions of midazolam].

1989 • 9 citations

Elevated serum theophylline concentration following cessation of erythromycin treatment.

1986 • 9 citations

Spiramycin does not increase plasma cyclosporin concentrations in renal transplant patients

1988 • 9 citations

Effect of Erythromycin Stearate on Serum Theophylline Concentration in Patients With Chronic Obstructive Lung Disease

1983 • 9 citations

[Influence of a new macrolide, dirithromycine, on the clearance of antipyrine].

1987 • 8 citations

Miocamycin and theophylline blood levels.

1986 • 7 citations

[Acute ergotism caused by dihydroergotamine-triacetyloleandomycin association].

1978 • 7 citations

Roxithromycin and controlled release theophylline, an interaction study.

1988 • 6 citations

[Theophylline and antibiotics. Absence of interaction with josamycin].

1984 • 6 citations

Miocamycin doesn't affect theophylline serum levels in COPD patients.

1988 • 6 citations

Theophylline-erythromycin base interaction: case report and kinetic profile.

1983 • 6 citations

Theophylline-erythromycin interaction in an infant.

1982 • 6 citations

Effects of in vivo treatment with a new fluorinated macrolide (P-0501A) and other erythromycins on drug clearance and hepatic functions in perfused rat liver.

1986 • 5 citations

[Drug interactions with macrolids compared action of two macrolids on liver microsomal activity ].

1982 • 5 citations

Influence of theophylline on the renal clearance of erythromycin.

1987 • 5 citations

Screening for the influence of host factors on warfarin clearance using a single dose single sample procedure.

1986 • 5 citations

[Jaundice by interaction of troleandomycin and contraceptive pills (author's transl)].

1979 • 4 citations

Macrolide antibiotics and serum theophylline levels in relation to the severity of respiratory impairment: a comparison between the effects of erythromycin and josamycin.

1984 • 4 citations

The effects of three beta-lactamase inhibitors: YTR830H, sulbactam and clavulanic acid on the growth of human cells in culture.

1987 • 4 citations

Hepatic safety of erythromycin acistrate in 1549 patients with respiratory tract or skin infections

1991 • 3 citations

[Macrolide-theophylline interaction. Experiences in pediatrics].

1989 • 3 citations

[Absence of effect of josamycin on the pharmacokinetics of antipyrine].

1984 • 3 citations

[Josamycin in respiratory pathology in children being treated with theophylline].

1982 • 2 citations

Deleted Work

1955 • 0 citations