Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics

An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1978 • 618 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

Clinical Pharmacokinetics and Pharmacodynamics of Warfarin

1986 • 341 citations

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

1974 • 287 citations

Characterization of human cytochrome P450 enzymes

1992 • 227 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes

1987 • 203 citations

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

1983 • 192 citations

Purification and characterization of microsomal cytochrome P-450s

1982 • 157 citations

Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population.

1992 • 140 citations

Clinical Pharmacokinetics of Oral Anticoagulants

1979 • 131 citations

Enoxacin-warfarin interaction: Pharmacokinetic and stereochemical aspects

1987 • 127 citations

Stereoselective Interaction of Omeprazole with Warfarin in Healthy Men

1989 • 125 citations

Omeprazole Drug Interaction Studies

1991 • 125 citations

Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans

1987 • 114 citations

Stereoselective Interaction of Trimethoprim-Sulfamethoxazole with the Separated Enantiomorphs of Racemic Warfarin in Man

1980 • 112 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

Stereoselective interaction between the R enantiomer of warfarin and cimetidine.

1986 • 93 citations

Characteristics of warfarin hydroxylation catalyzed by human liver microsomes.

1989 • 88 citations

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

1989 • 87 citations

Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites.

1993 • 84 citations

A study of the interaction of omeprazole and warfarin in anticoagulated patients.

1992 • 76 citations

Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes.

1986 • 70 citations

Enantiomers of warfarin and vitamin K1 metabolism.

1986 • 67 citations

Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line.

1992 • 63 citations

Interaction between warfarin and propafenone in healthy volunteer subjects

1987 • 48 citations

The in vitro ketone reduction of warfarin and analogues

1989 • 46 citations

Inhibition of human liver cytochrome P‐450 by omeprazole.

1986 • 38 citations

Lack of effect of cimetidine on pharmacodynamics and kinetics of single oral doses of R- and S-acenocoumarol

1986 • 33 citations

4-Hydroxycoumarin Oral Anticoagulants : Pharmacokinetics-Response Relationship

1988 • 31 citations

Warfarin as A Probe of Cytochromes P 450 Function

1989 • 25 citations

Further insight into the stereoselective interaction between warfarin and cimetidine in man.

1991 • 25 citations

Stereoselective aspects in the pharmacokinetics and pharmacodynamics of acenocoumarol and its amino and acetamido derivatives in the rat.

1985 • 23 citations

Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4′-nitrowarfarin (Acenocoumarol)

1991 • 14 citations

Enantioselective Structure-pharmacokinetic Relationships of Ring Substituted Warfarin Analogues in the Rat

1990 • 14 citations

Properties and Stereoselectivity of Carbonyl Reductases Involved in the Ketone Reduction of Warfarin and Analogues

1993 • 14 citations

Post mortem characteristics of the hepatic microsomal drug oxidising enzyme system

1973 • 11 citations

Cimetidine‐nicoumalone interaction in man: stereochemical considerations.

1989 • 8 citations

Abhängigkeitsmaße: Korrelation und Regression

1984 • 3 citations

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