Plasma protein binding displacement interactions—why are they still regarded as clinically important?

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

THE PHARMACOLOGICAL BASIS OF THERAPEUTICS

1941 • 433 citations

Binding of Drugs to Serum Albumin

1976 • 410 citations

Drug Interactions with Coumarin Anticoagulants

1971 • 277 citations

The effect of organic acids on renal clearance of methotrexate in man

1969 • 267 citations

Potentiation of Anticoagulant Effect of Warfarin by Phenylbutazone

1967 • 236 citations

SULPHAPHENAZOLE-INDUCED HYPOGLYCÆMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS

1963 • 198 citations

Displacement of One Drug by Another from Carrier or Receptor Sites

1965 • 152 citations

The warfarin-sulfinpyrazone interaction: stereochemical considerations

1986 • 150 citations

Interaction between phenytoin and valproic acid: Plasma protein binding and metabolic effects

1980 • 115 citations

Stereoselective Interaction of Trimethoprim-Sulfamethoxazole with the Separated Enantiomorphs of Racemic Warfarin in Man

1980 • 112 citations

Phenylbutazone‐warfarin interaction in man: further stereochemical and metabolic considerations.

1983 • 110 citations

KINETICS AND CLINICAL IMPORTANCE OF DISPLACEMENT OF WARFARIN FROM ALBUMIN BY ACIDIC DRUGS*

1971 • 108 citations

Goth's Medical Pharmacology

1992 • 104 citations

Potentiation of Warfarin-Induced Hypoprothrombinemia by Chloral Hydrate

1970 • 99 citations

Protein Binding Displacement Interactions and their Clinical Importance

1983 • 97 citations

Mechanisms of inhibition of tolbutamide metabolism: Phenylbutazone, oxyphenbutazone, sulfaphenazole

1977 • 87 citations

Stereoselective Interaction of Phenylbutazone with [12C/13C]Warfarin Pseudoracemates in Man

1980 • 83 citations

Drug Interactions with Oral Sulphonylurea Hypoglycaemic Drugs

1977 • 81 citations

Aspirin alters methotrexate disposition in rheumatoid arthritis patients

1991 • 78 citations

Effect of plasma protein and tissue binding on the biologic half‐life of drugs

1978 • 75 citations

Plasma Protein Displacement Interactions Are Rarely of Clinical Significance

1979 • 68 citations

Pharmacokinetic Consequences of Drug Displacement from Blood and Tissue Proteins

1984 • 68 citations

Clinical pharmacokinetics

1990 • 56 citations

Drug Interactions. A Source Book of Adverse Interactions, Their Mechanisms, Clinical Importance and Management.

1982 • 51 citations

Potentiation of Anticoagulants Caused by Pyrazole Compounds

1964 • 50 citations

Effects of clofibrate and warfarin alone and in combination on the disposition of vitamin K1.

1979 • 42 citations

Clofibrate displaces warfarin from plasma proteins in man: an example of a pure displacement interaction.

1979 • 37 citations

Protein binding of drugs in plasma, interstitial fluid and tissues: Effect on pharmacokinetics

1981 • 31 citations

Chloral Hydrate and Warfarin Interaction: Clinical Significance?

1971 • 25 citations

Kinetics of drug displacement interactions

1981 • 23 citations

Comparative interaction of sulfinpyrazone and phenylbutazone with racemic warfarin: alteration in vivo of free fraction of plasma warfarin.

1981 • 22 citations

Effect of phenylbutazone on the binding of vitamin K antagonists to albumin

1973 • 20 citations

Evaluations of Drug Interactions

1986 • 15 citations

Review of Medical Pharmacology

1977 • 7 citations

Drug Interactions: A Source Book of Adverse Interactions, Their Mechanisms, Clinical Importance and Management

1982 • 7 citations