[55] Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1985 • 301 citations

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.

1985 • 194 citations

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture.

1986 • 177 citations

Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone.

1988 • 143 citations

Dual effects of macrolide antibiotics on rat liver cytochrome P-450

1983 • 116 citations

Effects of erythromycin on hepatic drug-metabolizing enzymes in humans

1983 • 104 citations

Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450

1981 • 98 citations

Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humans

1982 • 88 citations

Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides.

1989 • 81 citations

Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats

1983 • 80 citations

Hypo activity of cytochrome P-450 after triacetyloleandomycin administration

1981 • 69 citations

Cytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agents

1982 • 57 citations

Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.

1983 • 52 citations

In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: Comparison with troleandomycin and erythromycin

1988 • 38 citations

The cytochrome P-450 metabolite complex derived from troleandomycin: Properties in vitro and stability in vivo

1984 • 31 citations

Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin.

1982 • 29 citations

Triacetyloleandomycin as inducer of cytochrome P-450 LM3c from rabbit liver microsomes

1985 • 27 citations

Cytochrome P-450 isozyme LM3b from rabbit liver microsomes. Induction by triacetyloleandomycin purification and characterization.

1983 • 25 citations

Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: Partial purification and properties of cytochrome P-450-troleandomycin metabolite complexes

1981 • 25 citations

In vitro interaction of rat liver cytochromes P-450 with erythromycin, oleandomycin and erythralosamine derivatives

1989 • 24 citations

Some erythromycin derivatives are strong inducers in rats of a cytochrome P-450 very similar to that induced by 16 α-pregnenol one carbonitrile

1985 • 22 citations

Atypical inductive properties of rifampicin

1979 • 21 citations

Inductive and repressive effects of rifampicin on rabbit liver microsomal cytochrome P-450

1984 • 21 citations

Decrease in a constitutive form of cytochrome P-450 by macrolide antibiotics

1989 • 20 citations

Isolation and partial characterization of a rifampicin induced rabbit liver microsomal cytochrome P-450

1985 • 18 citations

Effects of a new fluorinated macrolide (P-0501A) and other erythromycins on drug metabolizing enzymes in rat liver.

1986 • 11 citations

Specific drug binding to rat liver cytochrome P-450 isozymes induced by pregnenolone-16α-carbonitrile and macrolide antibiotics. Implications for drug interactions

1990 • 7 citations