Physiological Disposition of Hmg-Coa-Reductase Inhibitors

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Discovery, biochemistry and biology of lovastatin

1988 • 348 citations

Cytochrome P-450—Catalyzed Formation of Δ ⁴ -VPA, a Toxic Metabolite of Valproic Acid

1987 • 248 citations

Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug.

1990 • 240 citations

Preclinical evaluation of lovastatin

1988 • 203 citations

New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.

1987 • 196 citations

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

1989 • 172 citations

Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme a reductase inhibitors

1989 • 136 citations

The physiological disposition of lovastatin.

1989 • 123 citations

Mevalonate supplementation in pregnant rats suppresses the teratogenicity of mevinolinic acid, an inhibitor of 3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase

1983 • 103 citations

Chemistry, biochemistry, and pharmacology of HMG-CoA reductase inhibitors

1988 • 98 citations

Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B)

1983 • 94 citations

An unusual metabolite of testosterone. 17 beta-Hydroxy-4,6-androstadiene-3-one.

1986 • 70 citations

Oxidation of monosubstituted olefins by cytochromes P-450 and heme models: Evidence for the formation of aldehydes in addition to epoxides and allylic alcohols

1984 • 53 citations

Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse.

1990 • 46 citations

Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin.

1990 • 30 citations

Metabolism of lovastatin by rat and human liver microsomes in vitro.

1988 • 25 citations

Drugs inhibiting HMG-CoA reductase

1985 • 17 citations

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