Basolateral Secretion of Amyloid Precursor Protein in Madin-Darby Canine Kidney Cells Is Disturbed by Alterations of Intracellular pH and by Introducing a Mutation Associated with Familial Alzheimer's Disease

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

1988 • 1,737 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

1991 • 1,269 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

1993 • 809 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

1992 • 725 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Polarized sorting in epithelia

1990 • 544 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

Polarity of Epithelial and Neuronal Cells

1992 • 435 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture

1990 • 425 citations

Basolateral sorting of LDL receptor in MDCK cells: The cytoplasmic domain contains two tyrosine-dependent targeting determinants

1992 • 366 citations

Rab proteins and the road maps for intracellular transport

1993 • 276 citations

Polarized sorting of glypiated proteins in hippocampal neurons

1991 • 233 citations

Primary amines inhibit recycling of α2M receptors in fibroblasts

1980 • 213 citations

Dependence on pH of polarized sorting of secreted proteins

1987 • 212 citations

Constitutive apical secretion of an 80-kD sulfated glycoprotein complex in the polarized epithelial Madin-Darby canine kidney cell line.

1987 • 201 citations

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

1990 • 171 citations

Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cells

1993 • 167 citations

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.

1993 • 152 citations

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

1992 • 147 citations

The Alzheimer β-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

1993 • 141 citations

Human α2-macroglobulin: structure and function

1982 • 130 citations

Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p.

1993 • 125 citations

Secretory processing of the Alzheimer amyloid βA4 protein precursor is increased by protein phosphorylation

1992 • 109 citations

Generation of βA4 from the amyloid protein precursor and fragments thereof

1993 • 104 citations

Molecular Genetics of Alzheimer's Disease

1993 • 99 citations

“Secretase,” Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

1991 • 98 citations

Polarized secretion of beta-amyloid precursor proteinand amyloid beta-peptide in MDCK cells.

1994 • 95 citations

Intravesicular acidification correlates with binding of ADP-ribosylation factor to microsomal membranes.

1992 • 83 citations

Secretion of beta-amyloid precursor protein involves multiple cleavage sites.

1994 • 70 citations

Cultured human fibroblasts contain a large pool of precursor β₁‐integrin but lack an intracellular pool of mature subunit

1991 • 42 citations

Is ammonia a pathogenetic factor in Alzheimer's disease?

1993 • 41 citations

The amyloid β protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported

1991 • 33 citations

Association of a 19- and a 21-kDa GTP-binding protein to pancreatic microsomal vesicles is regulated by the intravesicular pH established by a vacuolar-type H+-ATPase

1992 • 25 citations

α2‐Macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells

1992 • 22 citations