The Alzheimer β-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Phase separation of integral membrane proteins in Triton X-114 solution.

1981 • 3,366 citations

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

1982 • 1,765 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Perturbation of vesicular traffic with the carboxylic ionophore monensin

1983 • 890 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

[6]Isolation of rat liver plasma membrane fragments in isotonic sucrose

1974 • 609 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts.

1982 • 569 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane.

1985 • 415 citations

Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithelial cell line.

1988 • 381 citations

Externally disposed plasma membrane proteins. I. Enzymatic iodination of mouse L cells.

1975 • 353 citations

Protease Nexin-II(amyloid β-protein Precursor): a Platelet α-Granule Protein

1990 • 299 citations

Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages.

1985 • 288 citations

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.

1990 • 283 citations

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1991 • 276 citations

Tyrosine sulfation is a trans-Golgi-specific protein modification.

1987 • 261 citations

Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membrane

1992 • 252 citations

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

1989 • 251 citations

Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

1993 • 213 citations

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1991 • 210 citations

Endocytosis and signals for internalization

1991 • 209 citations

A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function.

1992 • 205 citations

[46] Enzymic diagnosis of the genetic mucopolysaccharide storage disorders

1978 • 204 citations

Lectin-binding sites as markers of Golgi subcompartments: proximal-to-distal maturation of oligosaccharides.

1983 • 202 citations

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 202 citations

Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.

1987 • 197 citations

The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease

1992 • 182 citations

An enzymatic assay reveals that proteins destined for the apical or basolateral domains of an epithelial cell line share the same late Golgi compartments.

1985 • 154 citations

Amyloid β protein precursor and the pathogenesis of Alzheimer's disease

1989 • 149 citations

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

1992 • 147 citations

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects

1989 • 142 citations

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

1992 • 141 citations

Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

1990 • 141 citations

Chapter 10 Low Temperature-Induced Transport Blocks as Tools to Manipulate Membrane Traffic

1989 • 116 citations

Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.

1991 • 105 citations

Monensin and brefeldin A differentially affect the phosphorylation and sulfation of secretory proteins.

1992 • 93 citations

The lysosomal membrane glycoprotein lamp-1 is transported to lysosomes by two alternative pathways

1992 • 83 citations

Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity

1992 • 81 citations

The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton

1991 • 76 citations

Phase separation of the receptor for immunoglobulin E and its subunits in Triton X-114.

1984 • 67 citations

The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia

1990 • 61 citations

Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.

1992 • 56 citations

Alzheimer β/A4‐Amyloid Precursor Protein: Evidence for Putative Amyloidogenic Fragment

1992 • 55 citations

Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties.

1991 • 54 citations

β-Amyloid precursor protein localization in the Golgi apparatus in neuron and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons

1992 • 53 citations

Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.

1992 • 51 citations

Ultrastructural localization of the putative precursors of the A4 amyloid protein associated with Alzheimer's disease.

1990 • 34 citations

Protease inhibitors generate cytotoxic fragments from alzheimer amyloid protein precursor in cDNA-transfected glioma cells

1992 • 33 citations

α2‐Macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells

1992 • 22 citations

Differential expression of carboxyl terminal derivatives of amyloid precursor protein among cell lines

1992 • 21 citations

Isolation of a fraction enriched in the trans-Golgi network from baby hamster kidney cells

1988 • 21 citations

Characterization of β‐Amyloid Precursor Proteins With or Without the Protease‐Inhibitor Domain Using Anti‐Peptide Antibodies

1990 • 17 citations

The β-amyloid precursor protein is not processed by the regulated secretory pathway

1991 • 13 citations