Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

1982 • 1,765 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation

1983 • 504 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

1989 • 437 citations

Biochemical analysis of membranes

1977 • 351 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

[59] Inhibitors of lysosomal function

1983 • 331 citations

Protease Nexin-II(amyloid β-protein Precursor): a Platelet α-Granule Protein

1990 • 299 citations

Cell-free protein sorting to the regulated and constitutive secretory pathways

1990 • 289 citations

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1991 • 276 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

Tyrosine sulfation is a trans-Golgi-specific protein modification.

1987 • 261 citations

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

1989 • 251 citations

Temperature-sensitive steps in the transport of secretory proteins through the Golgi complex in exocrine pancreatic cells.

1986 • 251 citations

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1991 • 210 citations

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 202 citations

Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate.

1989 • 196 citations

Dissection of Semliki Forest virus glycoprotein delivery from the trans-Golgi network to the cell surface in permeabilized BHK cells.

1988 • 178 citations

Intracellular degradation of unassembled asialoglycoprotein receptor subunits: a pre-Golgi, nonlysosomal endoproteolytic cleavage.

1989 • 146 citations

Nerve and epidermal growth factors induce the release of the Alzheimer Amyloid precursor from PC 12 cell cultures

1989 • 133 citations

Chapter 10 Low Temperature-Induced Transport Blocks as Tools to Manipulate Membrane Traffic

1989 • 116 citations

Evidence for lysosomal processing of amyloid ?-protein precursor in cultured cells

1989 • 114 citations

“Secretase,” Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

1991 • 98 citations

An antibody specific for an endoproteolytic cleavage site provides evidence that pro-opiomelanocortin is packaged into secretory granules in AtT20 cells before its cleavage.

1987 • 90 citations

Platelet alpha-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes.

1990 • 90 citations

Soluble derivatives of the β amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β amyloid protein

1989 • 85 citations

Chloroquine inhibits intracellular segradation but not decretion of Alzheimerβ/A4 amyloid precursor protein.

1992 • 80 citations

The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton

1991 • 76 citations

Differential brain expression of the Alzheimer's amyloid precursor protein.

1989 • 75 citations

The endosomal concentration of a mannose 6-phosphate receptor is unchanged in the absence of ligand synthesis.

1987 • 59 citations

Enzyme specificity of proteinase inhibitor region in amyloid precursor protein of Alzheimer's disease: different properties compared with protease nexin I

1990 • 55 citations

Intracellular processing of the vesicular stomatitis virus glycoprotein and the Newcastle disease virus hemagglutinin-neuraminidase glycoprotein

1984 • 42 citations

Evidence for endocytosis-dependent proteolysis in the generation of soluble truncated nerve growth factor receptors by A875 human melanoma cells

1991 • 36 citations

Chapter 2 Digitonin Permeabilization Procedures for the Study of Endosome Acidification and Function

1989 • 30 citations

Vesicles without clathrin: Intermediates in bulk flow exocytosis

1989 • 8 citations

Effects of Neurotrophic Factors on the Secretion and Metabolism of the Alzheimer Amyloid Precursor

1991 • 3 citations