Activation of NF-κB Binding in HT-29 Colon Cancer Cells by Inhibition of Phosphatidylinositol 3-Kinase

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Oncogenes and signal transduction

1991 • 2,816 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

2000 • 1,125 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1999 • 689 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Phosphoinositide kinases

1996 • 529 citations

TOR signalling and control of cell growth

1997 • 458 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

1997 • 433 citations

Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis

1995 • 392 citations

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529

1998 • 375 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria.

1999 • 334 citations

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

1994 • 332 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

NF-κB Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria

1999 • 272 citations

Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

1996 • 232 citations

Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway

1998 • 216 citations

Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells

1996 • 210 citations

Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells.

1997 • 183 citations

Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10.

1999 • 154 citations

Type 1 and Type 2 Cytokine Regulation of Macrophage Endocytosis: Differential Activation by IL-4/IL-13 as Opposed to IFN-γ or IL-10

1999 • 122 citations

Rac1 Regulates Interleukin 1-induced Nuclear Factor κB Activation in an Inhibitory Protein κBα-independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression

2000 • 86 citations

Activation of Phosphatidylinositol 3-Kinase by Interleukin-13

1997 • 85 citations

Induced differentiation in HT29, a human colon adenocarcinoma cell line

1999 • 84 citations

IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.

1998 • 71 citations

Interleukin-1-induced Nuclear Factor-κB-IκBα Autoregulatory Feedback Loop in Hepatocytes

1999 • 70 citations

Phosphatidylinositol 3-Kinase Is a Negative Regulator of Cellular Differentiation

1997 • 68 citations

IL-13 Suppresses TNF-Induced Activation of Nuclear Factor-κB, Activation Protein-1, and Apoptosis

1998 • 60 citations

The study of phosphoinositide 3-kinase function.

1996 • 57 citations

Cellular Differentiation Causes a Selective Down-regulation of Interleukin (IL)-1β-mediated NF-κB Activation and IL-8 Gene Expression in Intestinal Epithelial Cells

2000 • 52 citations

Downregulation of mitogen-activated protein kinases in human colon cancers.

2000 • 52 citations

Heparin/heparan sulfate interacting protein gene expression is up-regulated in human colorectal carcinoma and correlated with differentiation status and metastasis.

1999 • 20 citations

Enterocyte-like differentiation of the Caco-2 intestinal cell line is associated with increases in AP-1 protein binding

1998 • 20 citations