Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Enzymatic control of pigmentation in mammals

1991 • 747 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1995 • 441 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Mammalian tyrosinase—The critical regulatory control point in melanocyte pigmentation

1987 • 439 citations

Progress in the chemistry of melanins and related metabolites

1988 • 387 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

1994 • 332 citations

Phosphoinositide kinases

1990 • 331 citations

A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.

1992 • 326 citations

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.

1992 • 319 citations

Regulation of tyrosinase in human melanocytes grown in culture.

1983 • 288 citations

Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis.

1995 • 269 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

Analysis of Mammalian Pigmentation at the Molecular Level

1989 • 238 citations

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression

1994 • 233 citations

Tyrosinases from two different loci are expressed by normal and by transformed melanocytes.

1991 • 233 citations

α-melanocyte stimulating hormone and its analogue nle4dphe7α-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes

1994 • 229 citations

Induction of Skin Tanning by Subcutaneous Administration of a Potent Synthetic Melanotropin

1991 • 205 citations

Nuclear localization of p85s6k: functional requirement for entry into S phase.

1994 • 202 citations

Mitogen-activated Protein Kinase Pathway and AP-1 Are Activated during cAMP-induced Melanogenesis in B-16 Melanoma Cells

1995 • 200 citations

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

1996 • 168 citations

Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells.

1995 • 166 citations

Activation of pp70/85 S6 Kinases in Interleukin-2-Responsive Lymphoid Cells Is Mediated by Phosphatidylinositol 3-Kinase and Inhibited by Cyclic AMP

1995 • 164 citations

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.

1993 • 161 citations

Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells

1975 • 157 citations

Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.

1996 • 147 citations

Pigment Production in Murine Melanoma Cells Is Regulated by Tyrosinase, Tyrosinase-Related Protein 1 (TRP1), DOPAchrome Tautomerase (TRP2), and a Melanogenic Inhibitor

1993 • 134 citations

Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

1994 • 134 citations

Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase

1996 • 130 citations

Alpha-melanocyte-stimulating hormone regulation of tyrosinase in Cloudman S-91 mouse melanoma cell cultures.

1987 • 123 citations

Specific Identification of an Authentic Clone for Mammalian Tyrosinase

1989 • 106 citations

Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes

1992 • 99 citations

Phosphatidylinositol 3-kinase: a novel effector.

1992 • 99 citations

Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression.

1994 • 99 citations

Molecular Cloning, cDNA Sequence, and Chromosomal Localization of the Human Phosphatidylinositol 3-Kinase p110α (PIK3CA) Gene

1994 • 91 citations

Phosphoinositide 3-Kinase as an Upstream Regulator of the Small GTP-Binding Protein Rac in the Insulin Signaling of Membrane Ruffling

1995 • 78 citations

Rapid and Reversible Inhibition of Tyrosinase Activity by Glucosidase Inhibitors in Human Melanoma Cells

1992 • 70 citations

Cyclic AMP-increasing Agents Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3-Kinase Rather than Receptor-operated Ca2+ Influx

1995 • 69 citations

Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.

1994 • 61 citations

Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.

1992 • 44 citations

Activation of p70 S6 Kinase and erk-encoded Mitogen-activated Protein Kinases Is Resistant to High Cyclic Nucleotide Levels in Swiss 3T3 Fibroblasts

1995 • 33 citations