Mechanisms of complex transcriptional regulation: implications for brain development

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

1990 • 3,134 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure

1987 • 1,771 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

1990 • 1,630 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

Neural Crest and the Origin of Vertebrates: A New Head

1983 • 1,011 citations

The structure and function of the homeodomain

1989 • 1,007 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

1990 • 959 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

1989 • 781 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

A new class of yeast transcriptional activators

1987 • 706 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

‘Zinc fingers’: a novel protein motif for nucleic acid recognition

1987 • 676 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite

1989 • 661 citations

Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins

1990 • 656 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain

1989 • 630 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

The unc-86 gene product couples cell lineage and cell identity in C. elegans

1990 • 606 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

Murine Developmental Control Genes

1990 • 594 citations

mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans

1988 • 573 citations

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

1989 • 566 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors

1990 • 533 citations

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

1991 • 527 citations

Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

1988 • 525 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

1991 • 517 citations

Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse

1989 • 511 citations

Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer

1989 • 508 citations

The achaete-scute gene complex of D. melanogaster: Conserved Domains in a subset of genes required for neurogenesis and their homology to myc

1987 • 501 citations

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

1986 • 497 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Globin gene regulation and switching: Circa 1990

1990 • 463 citations

POU-domain transcription factors: pou-er-ful developmental regulators.

1991 • 461 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex

1988 • 442 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

1990 • 430 citations

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins

1990 • 407 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor

1990 • 403 citations

Spatially and temporally restricted expression of Pax2 during murine neurogenesis

1990 • 397 citations

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

1991 • 395 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

1988 • 393 citations

Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

1991 • 390 citations

The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein

1990 • 387 citations

Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor

1988 • 370 citations

The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily

1990 • 361 citations

The cellular basis of segmentation in the developing hindbrain

1990 • 358 citations

GAL4 activates gene expression in mammalian cells

1988 • 355 citations

RNA Polymerase B (II) And General Transcription Factors

1990 • 355 citations

Oestrogen and glucocorticoid responsive elements are closely related but distinct

1987 • 353 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

Genetic Control of Differentiation of the Caenorhabditis elegans Touch Receptor Neurons

1989 • 344 citations

Expression and Function of the Segmentation Gene fushi tarazu During Drosophila Neurogenesis

1988 • 342 citations

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors

1988 • 334 citations

Expression of homeo box genes during mouse development: a review.

1988 • 331 citations

Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

1990 • 330 citations

Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein

1988 • 325 citations

Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MATα cells

1988 • 323 citations

The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.

1989 • 318 citations

Yeast HAP1 activator binds to two upstream activation sites of different sequence

1987 • 317 citations

Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant

1991 • 302 citations

A Domain Containing Leucine-Zipper-Like Motifs Mediate Novelin VivoInteractions between the Thyroid Hormone and Retinoic Acid Receptors

1989 • 293 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila

1988 • 289 citations

Genesis of the Drosophila peripheral nervous system

1989 • 289 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes.

1988 • 271 citations

Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements

1989 • 270 citations

Control of neuronal fate by the Drosophila segmentation gene even-skipped

1988 • 264 citations

Retinoids and vertebrate limb pattern formation

1989 • 251 citations

The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

1989 • 245 citations

Expression and Activity of the POU Transcription Factor SCIP

1990 • 244 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

Retinoids, homeobox genes, and limb morphogenesis

1989 • 242 citations

Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.

1990 • 238 citations

Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP

1989 • 237 citations

Regulation of transcription and cell identity by POU domain proteins

1991 • 233 citations

Drosophila Krüppel protein is a transcriptional represser

1990 • 228 citations

Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.

1990 • 227 citations

Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors

1991 • 224 citations

Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development

1991 • 223 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain

1989 • 214 citations

Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor

1990 • 211 citations

Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements

1991 • 206 citations

Caenorhabditis elegans has scores of homoeobox-containing genes

1989 • 197 citations

A multifaceted approach to neural development

1989 • 194 citations

A molecular framework for the actions of glucocorticoid hormones in the nervous system

1989 • 193 citations

rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye

1988 • 189 citations

Regulation of synaptic transmission in the central nervous system: Long-term potentiation

1989 • 186 citations

A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.

1990 • 185 citations

The origins of cellular diversity in the mammalian central nervous system

1989 • 173 citations

Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene.

1990 • 172 citations

Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons

1990 • 170 citations

The 65-kD subunit of NF-kappa B is a receptor for I kappa B and a modulator of DNA-binding specificity.

1990 • 167 citations

Retrovirus vectors and their applications in neurobiology

1988 • 162 citations

Drosophila melanogaster as an Experimental Organism

1988 • 158 citations

Biochemistry of Information Storage in the Nervous System

1987 • 147 citations

A brain-specific transcription activator

1989 • 141 citations

Molecular approaches to the segmentation of the hindbrain

1990 • 135 citations

Protein Kinases in the Brain

1985 • 134 citations

Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.

1991 • 127 citations

Mechanisms of trans-synaptic regulation of gene expression

1987 • 125 citations

Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation.

1991 • 120 citations

The Nematode Caenorhabditis elegans

1988 • 119 citations

Mechanisms for diversity in gene expression patterns

1991 • 114 citations

The multifunctional Ca2+/calmodulin-dependent protein kinase.

1988 • 99 citations

Steroid hormones are multifunctional messengers to the brain

1991 • 85 citations

Manipulating the mouse genome: Implications for neurobiology

1990 • 69 citations

Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, rough

1988 • 59 citations

Caenorbabditis elegans has scores of homeobox-containing genes

1989 • 42 citations

Homeogenes in mammalian development and the evolution of the cranium and central nervous system

1990 • 27 citations

Molecular and genetic analysis of Drosophila eye development: sevenless, bride of sevenless and rough

1989 • 25 citations

Steroid hormone receptor homologs in development

1989 • 11 citations

Blood donors to be screened

1989 • 10 citations

Chapter 85 Reconstructing the brain from immortal cell lines

1988 • 8 citations