Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects

Type I Diabetes Mellitus

1986 • 1,615 citations

ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES

1974 • 1,463 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

The Pathogenesis of Insulin-Dependent Diabetes Mellitus

1994 • 1,077 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis

1995 • 393 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Combined Analysis of Autoantibodies Improves Prediction of IDDM in Islet Cell Antibody-Positive Relatives

1994 • 360 citations

Insulin prophylaxis in individuals at high risk of type 1 diabetes

1993 • 303 citations

Insulitis and Diabetes in NOD Mice Reduced by Prophylactic Insulin Therapy

1990 • 296 citations

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1992 • 275 citations

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease.

1996 • 270 citations

Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).

1995 • 257 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells

1991 • 236 citations

Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation

1993 • 211 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA

1991 • 206 citations

T-Lymphocyte Clone Specific for Pancreatic Islet Antigen

1988 • 188 citations

T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins

1990 • 179 citations

Lack of Immune Responsiveness to Bovine Serum Albumin in Insulin-Dependent Diabetes

1993 • 163 citations

Type I Diabetes Mellitus: A Chronic Autoimmune Disease?

1984 • 141 citations

Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity

1994 • 134 citations

ICA512 Autoantibody Radioassay

1995 • 128 citations

Correlates of Insulin Antibodies in Newly Diagnosed Children with Insulin-dependent Diabetes Before Insulin Therapy

1985 • 126 citations

Cellular Immune Response to Diverse Islet Cell Antigens in IDDM

1996 • 123 citations

Anti-glutamate decarboxylase and other antibodies at the onset of childhood IDDM: a population-based study

1994 • 123 citations

Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives

1994 • 114 citations

Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes.

1993 • 113 citations

T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes

1991 • 110 citations

T cell autoreactivity to insulin in diabetic and related non-diabetic individuals.

1988 • 100 citations

Islet-Specific T-Cell Clones From the NOD Mouse Respond to β-Granule Antigen

1994 • 99 citations

Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy

1990 • 97 citations

Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes

1988 • 96 citations

T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM

1995 • 83 citations

T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects

1997 • 81 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1994 • 75 citations

The nature of autoantigens targeted in autoimmune endocrine diseases

1996 • 69 citations

Anti-Insulin Antibodies in Children With Type I Diabetes Mellitus: Genetic Regulation of Production and Presence at Diagnosis Before Insulin Replacement

1986 • 68 citations

T-lymphocyte clone specific for pancreatic islet antigen

1988 • 67 citations

HLA‐associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent‐onset insulin‐dependent diabetes mellitus

1996 • 66 citations

Cellular immunity to human insulin in individuals at high risk for the development of Type I diabetes mellitus

1990 • 62 citations

Isohormonal therapy of endocrine autoimmunity

1995 • 62 citations

Reactivity to Human Islets and Fetal Pig Proislets by Peripheral Blood Mononuclear Cells From Subjects With Preclinical and Clinical Insulin-Dependent Diabetes

1991 • 53 citations

Correlates of insulin antibodies in newly diagnosed children with insulin-dependent diabetes before insulin therapy

1985 • 51 citations

Cell-mediated Immunity in Diabetes Mellitus Lymphocyte Transformation by Insulin and Insulin Fragments in Insulin-treated and Newly-diagnosed Diabetics

1975 • 51 citations

ICA512 autoantibody radioassay

1995 • 49 citations

Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors.

1993 • 48 citations

Cellular immune response to diverse islet cell antigens in IDDM

1996 • 48 citations

Islet-specific T-cell clones from the NOD mouse respond to beta-granule antigen

1994 • 44 citations

Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity

1994 • 41 citations

Sexual dimorphism in transmission of expression of islet autoantibodies to offspring

1995 • 31 citations

Anti-insulin antibodies in children with type I diabetes mellitus. Genetic regulation of production and presence at diagnosis before insulin replacement

1986 • 29 citations

T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM

1995 • 27 citations

Insulin-specific human T cells. Epitope specificity, major histocompatibility complex restriction, and alloreactivity to a diabetes-associated haplotype.

1987 • 26 citations

Establishment of Islet-specific T-cell Lines and Clones from Islet Isografts Placed in Spontaneously Diabetic NOD Mice

1993 • 25 citations

Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes

1991 • 24 citations

Proliferative responses of T-cells to thyroid antigens and synthetic thyroid peroxidase peptides in autoimmune thyroid disease.

1995 • 23 citations

Recognition of human insulin in vitro by T cells from subjects treated with animal insulins.

1985 • 21 citations

Islet cell and 64K autoantibodies are associated with plasma IgG in newly diagnosed insulin-dependent diabetic children.

1986 • 20 citations

Insulin responses and lymphocyte subclasses in children with newly diagnosed insulin-dependent diabetes.

1988 • 18 citations

Anti-glutamate decarboxylase and other antibodies at the onset of childhood IDDM: a population-based study

1994 • 18 citations

Immune Responses to Insulin and Lymphocyte Subclasses at Diagnosis of Insulin-Dependent Diabetes and One Year Later

1990 • 17 citations

Heterogeneity of type 1 diabetes at onset in children: results from the French Incidence Study.

1993 • 14 citations

Proliferative responses of T-cells to thyroid antigens and synthetic thyroid peroxidase peptides in autoimmune thyroid disease

1995 • 10 citations

Bovine and human NPH insulins as T cell immunogens

1993 • 5 citations

Insulin Autoantibodies in Pre-Diabetes

1988 • 5 citations

Sexual dimorphism in transmission of expression of islet autoantibodies to offspring

1995 • 3 citations