WNT signalling in the immune system: WNT is spreading its wings

Wnt/β-Catenin Signaling in Development and Disease

2006 • 5,286 citations

Wnt signalling in stem cells and cancer

2005 • 3,593 citations

Identification of the haematopoietic stem cell niche and control of the niche size

2003 • 2,900 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

A role for Wnt signalling in self-renewal of haematopoietic stem cells

2003 • 2,131 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

2002 • 1,601 citations

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

2003 • 1,491 citations

Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML

2004 • 1,472 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

2002 • 1,095 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

2005 • 806 citations

Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors

2003 • 770 citations

Wnt/β-catenin signaling in cancer stemness and malignant behavior

2007 • 757 citations

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 • 679 citations

Balancing cell adhesion and Wnt signaling, the key role of β-catenin

2005 • 636 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo

2007 • 576 citations

Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

2005 • 569 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

2008 • 485 citations

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

2007 • 453 citations

Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

2000 • 444 citations

Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus

2007 • 436 citations

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

2006 • 435 citations

Launching the T-cell-lineage developmental programme

2007 • 433 citations

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

2005 • 404 citations

Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells

2007 • 403 citations

Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

2006 • 389 citations

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

2006 • 357 citations

A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells

1997 • 355 citations

β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

2004 • 354 citations

Wnt Signaling Induces Matrix Metalloproteinase Expression and Regulates T Cell Transmigration

2007 • 350 citations

Disruption of E-Cadherin-Mediated Adhesion Induces a Functionally Distinct Pathway of Dendritic Cell Maturation

2007 • 348 citations

Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation

2001 • 348 citations

Signaling pathways governing stem-cell fate

2007 • 345 citations

T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants

1984 • 344 citations

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

2003 • 337 citations

Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1

1998 • 337 citations

SnapShot: Noncanonical Wnt Signaling Pathways

2007 • 335 citations

Role of Members of the Wnt Gene Family in Human Hematopoiesis

1998 • 333 citations

Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue

2003 • 325 citations

New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling

2005 • 323 citations

WNT signalling and haematopoiesis: a WNT–WNT situation

2005 • 315 citations

Wnt signals are transmitted through N‐terminally dephosphorylated β‐catenin

2002 • 313 citations

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

2004 • 308 citations

Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells

2004 • 301 citations

Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation

2007 • 289 citations

Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

2005 • 245 citations

The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival

2001 • 241 citations

Critical Involvement of Tcf-1 in Expansion of Thymocytes

1998 • 238 citations

The Thymus as an Inductive Site for T Lymphopoiesis

2007 • 220 citations

Long-term, multilineage hematopoiesis occurs in the combined absence of β-catenin and γ-catenin

2007 • 213 citations

NFAT signaling in vertebrate development

2001 • 213 citations

Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activator function

2004 • 204 citations

Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis

2007 • 202 citations

LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

2006 • 195 citations

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

2001 • 193 citations

WNT-1 and HGF Regulate GSK3β Activity and β-Catenin Signaling in Mammary Epithelial Cells

1998 • 187 citations

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

2008 • 185 citations

Expression of β-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis

2006 • 183 citations

Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-1) following Antigen Encounter In Vitro and In Vivo

2006 • 180 citations

Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

2001 • 175 citations

Deletion of β-catenin impairs T cell development

2003 • 170 citations

ICAT Inhibits β-Catenin Binding to Tcf/Lef-Family Transcription Factors and the General Coactivator p300 Using Independent Structural Modules

2002 • 168 citations

SnapShot: Wnt/β-Catenin Signaling

2007 • 162 citations

Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells

2007 • 155 citations

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

1999 • 151 citations

CBP/p300 are bimodal regulators of Wnt signaling

2007 • 137 citations

β-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation

2007 • 120 citations

Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules

2006 • 119 citations

Wnt Target Genes Identified by DNA Microarrays in Immature CD34+ Thymocytes Regulate Proliferation and Cell Adhesion

2004 • 117 citations

Frizzled 9 knock-out mice have abnormal B-cell development

2004 • 116 citations

A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis

2008 • 114 citations

Wnt-1 and Wnt-4 regulate thymic cellularity

2002 • 113 citations

Wnt signaling in the stem cell niche

2004 • 110 citations

Loss of adenomatous polyposis coli gene function disrupts thymic development

2005 • 108 citations

The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF–β-catenin-mediated transcription

2005 • 106 citations

Wnt-3a-dependent Cell Motility Involves RhoA Activation and Is Specifically Regulated by Dishevelled-2*[boxs]

2004 • 103 citations

Production of Wnt Inhibitors by Myeloma Cells: Potential Effects on Canonical Wnt Pathway in the Bone Microenvironment

2007 • 103 citations

Cyclin D1 Is Not an Immediate Target of β-Catenin following Apc Loss in the Intestine

2005 • 101 citations

Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct Catenin Subfamilies Promote Wnt Signals

2006 • 96 citations

Constitutively Active β-Catenin Confers Multilineage Differentiation Potential on Lymphoid and Myeloid Progenitors

2005 • 95 citations

Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia

2006 • 86 citations

Age-related changes in the cellular composition of the thymus in children

2005 • 86 citations

Wnt signaling in the thymus

2003 • 82 citations

Negotiation of the T Lineage Fate Decision by Transcription-Factor Interplay and Microenvironmental Signals

2007 • 80 citations

Transcriptional Control of T Lymphocyte Differentiation

2001 • 78 citations

Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells

1999 • 78 citations

Endothelial Cells Stimulate T Cell NFAT Nuclear Translocation in the Presence of Cyclosporin A: Involvement of the wnt/Glycogen Synthase Kinase-3β Pathway

2002 • 76 citations

β-Catenin Expression Results in p53-Independent DNA Damage and Oncogene-Induced Senescence in Prelymphomagenic Thymocytes In Vivo

2007 • 70 citations

GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen

2007 • 66 citations

Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis

2006 • 65 citations

Cooperating pre–T-cell receptor and TCF-1–dependent signals ensure thymocyte survival

2005 • 65 citations

-Catenin expression enhances generation of mature thymocytes

2003 • 59 citations

Noncanonical Wnt signaling promotes apoptosis in thymocyte development

2007 • 52 citations

Overexpression of ICAT highlights a rolefor catenin‐mediated canonical Wnt signalling in early T cell development

2006 • 51 citations

T-sing progenitors to commit

2006 • 47 citations

T-cell generation by lymph node resident progenitor cells

2005 • 46 citations

The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.

1992 • 44 citations

Transcriptional Regulation of CD4 Gene Expression by T Cell Factor-1/β-Catenin Pathway

2006 • 43 citations

β-Catenin Regulates Positive Selection of Thymocytes but Not Lineage Commitment

2007 • 34 citations

Wnt signaling and phosphorylation status of β-catenin: importance of the correct antibody tools

2007 • 33 citations

β-Catenin Expression Enhances IL-7 Receptor Signaling in Thymocytes during Positive Selection

2007 • 31 citations

Wnt Signaling in Lymphopoiesis

2005 • 18 citations