Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

1998 • 874 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1993 • 710 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1997 • 488 citations

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 • 482 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

1997 • 386 citations

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

1998 • 382 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

The presenilins and Alzheimer's disease

1997 • 364 citations

A Novel Repressor, par-4, Modulates Transcription and Growth Suppression Functions of the Wilms’ Tumor Suppressor WT1

1996 • 254 citations

Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells.

1994 • 229 citations

Increased Sensitivity to Mitochondrial Toxin-Induced Apoptosis in Neural Cells Expressing Mutant Presenilin-1 Is Linked to Perturbed Calcium Homeostasis and Enhanced Oxyradical Production

1998 • 222 citations

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function

1998 • 216 citations

Expression and Function of the Leucine Zipper Protein Par-4 in Apoptosis

1997 • 205 citations

Amyloid β-peptide and oxidative cellular injury in Alzheimer’s disease

1996 • 132 citations

Increased Apoptosis Arising from Increased Expression of the Alzheimer's Disease–associated Presenilin-2 Mutation (N141I)

1997 • 118 citations

Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1

1997 • 117 citations

Protein kinase C involvement in apoptosis

1995 • 99 citations

Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues.

1997 • 68 citations

Chapter 11 Neurotrophic Factors and the Aging Brain

1997 • 18 citations

Chapter 6 Contribution of Mitochondrial Alterations to Brain Aging

1997 • 11 citations